Phase 2 N=240 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA
CRPS
Primary: Epidural Medication Consumption Rate — 6.40; 5.77 mL/h — p=0.003
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=22 Investigation of the Efficacy of tDCS in the Treatment of Complex Regional Pain Syndrome (CRPS) Type 1
Reflex Sympathetic Dystrophy
Primary: Pain Severity — 22.18; 23.36; 18.00; 23.82 units on a scale — p=0.065
N/A N=20 Transcranial Magnetic Stimulation (TMS) for CRPS
Complex Regional Pain Syndrome (CRPS)
Primary: Present Pain Intensity — 6.5; 6.3; 3.1; 3.7 Units on a scale
N/A N=66 "Liposomal Encapsulated Vitamin C in Complex Regional Pain Syndrome"
Complex Regional Pain Syndrome I of Lower Limb
Primary: Number of Participants Operated for Complex Regional Pain Syndrome Who Had Transposition of Anterior Tibial Tuberosity — 1; 0; 2 participants
N/A N=4 TMS for CRPS - Pilot Study
Complex Regional Pain Syndrome (CRPS)
Primary: Change in Pain — 5.2; 0.7 units on a scale
Phase 3 N=44 Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome
Complex Regional Pain Syndrome
Primary: Pain Score — 5.9; 6.0; 6.5; 6.8 score on a scale — p=0.19
Phase 3 N=318 Safety of Intravenous Neridronic Acid in CRPS
Complex Regional Pain Syndrome
Primary: Number of Participants With Occurrence of Any Treatment Emergent Adverse Event (TEAE) — 277; 27; 275; 267 Participants
N/A N=8 Peripheral Sensory Input in Central Post Stroke Pain (CPSP)
Central Post Stroke Pain
Primary: Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block. — 6.5; 0.0 units on a scale
Phase 2 N=24 Study of TAK-935 as an Adjunctive Therapy in Adult Participants With Complex Regional Pain Syndrome (CRPS)
Complex Regional Pain Syndrome
Primary: Change From Baseline in Mean 24-Hour Pain Intensity as Assessed by NPS Score to the End of Part A — -0.74; -1.05 scores on scale
N/A N=36 Virtual Reality Guided Imagery for Chronic Pain
Complex Regional Pain Syndromes · Back Pain
Primary: Number of Participants Who Are Recruited But Not Enrolled as Documented in Participant Log — 60 Participants
N/A N=152 A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain
Chronic Lower Limb Pain
Primary: Primary Composite Endpoint - Treatment Success — 81.2; 55.7 percentage of subjects — p=<0.0001
N/A N=15 Spinal Cord Stimulation for Restless Legs Syndrome
Restless Legs Syndrome · Neuropathic Pain
Primary: Percent Change MSNA Burst Frequency From Baseline to 60 Minutes — -29; -24 Percent change MSNA burst frequency
Phase 2 N=22 3D Augmented Reality Mirror Visual Feedback Applied to the Treatment of Unilateral Upper Extremity Neuropathic Pain.
Neuralgia
Primary: Pain on the Visual Analog Scale (VAS) — 6.4; 4.0 units on a scale
N/A N=26 Surgical Treatment of Post-surgical Mastectomy Pain Utilizing the Regenerative Peripheral Nerve Interface
Post-Mastectomy Chronic Pain Syndrome
Primary: Change in Pain Level — 6.9; 0.6; 4.4; 2.5 score on a scale
N/A N=8 C-RFA of Residual Limb Neuroma
Phantom Limb Pain · Neuroma Amputation
Primary: Numeric Rating Scale (NRS) for Pain at 6 Months — 4 Participants
N/A N=64 Remote Ischemic PreConditioning Effect on Postsurgical Pain
Pain
Primary: Comparison of Pain Intensity and Unpleasantness Postoperatively — 4.82; 4.83; 4.05; 4.81 units on a scale
N/A N=94 Bioness® StimRouter™ Neuromodulation System for Chronic Pain Therapy
Chronic Pain
Primary: Brief Pain Inventory (BPI): Number of Participants With a Pain Reduction of Greater Than or Equal to 30% — 17; 5 participants — p=0.0048
Phase 2 N=132 Topiramate for Cryptogenic Sensory Peripheral Neuropathy in Metabolic Syndrome (CSPN)
Cryptogenic Sensory Peripheral Neuropathy in Metabolic Syndrome
Primary: Intraepidermal Nerve Fiber Density (IENFD) — -0.6064; -0.396 fibers/mm/year (52 weeks)
N/A N=38 Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Chronic Pain · Chronic Lower Back Pain · Back Pain
Primary: Changes in Patient Reported Pain and Discomfort — 47; 13; -30; -18 percent change from baseline
Phase 2 N=19 Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain
Fibromyalgia · Chronic Pain · Depression
Primary: Gracely Box Intensity Rating Scale — 13.18; 14.43; 10.64; 13.00 units on a scale
Phase 2 N=10 Acute Human Study: StimRouter for Peripheral Nerve Stimulation of Discrete Peripheral Nerves
Unilateral Carpal Tunnel Syndrome
Primary: Implant Success — 10 participants with successful implant
Phase 3 N=140 Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery
Breast Cancer Patient
Primary: Change in Neuropathic Pain Score at 2 Months (Numeric Rating Scale 0-10) — 4.1; 4.6 units on a scale
Phase 3 N=65 An Implantable Spinal Cord Stimulation Pain Management System
Chronic Pain · Pain, Intractable · Pain
Primary: Change in Visual Analog Scale (VAS) Score From Baseline to 2 Week Post Initial Fitting. — 35 participants with > 50% VAS improvement
N/A N=133 Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study)
Restless Legs Syndrome
Primary: Number of Subjects for Which the Clinician Reported "Much Improved" or "Very Much Improved" on the Clinical Global Impressions-Improvement (CGI-I) Scale for TOMAC…
N/A N=10 Botulinum Toxin in the Treatment of Raynaud's
Raynaud's Syndrome
Primary: Mean Digital Temperature Difference From Baseline — 1.30 Celsius
Phase 3 N=258 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome
Postherpetic Neuralgia · Complex Regional Pain Syndromes (CRPS) · Postoperative Pain
Primary: Time From the Initial Day of Application in Double-Blind Period to Withdrawal Because of Insufficient Analgesic Efficacy — NA; 45.0 Days — p=0.0003
N/A N=23 Immersive Virtual Reality and Chronic Back Pain
Chronic Back Pain
Primary: Pain Numerical Rating Scale — 0.8; 1.1 units on a scale
N/A N=18 High Rate Spinal Cord Stimulation (SCS) for Chronic Pain
Chronic Pain
Primary: Change in Back Pain Intensity — 20.9; 25.6 Percent Change From Baseline — p=0.74
N/A N=9 Transcranial Magnetic Stimulation for Facial Pain
Trigeminal Nerve Injuries · Post-herpetic Neuralgia · Facial Pain
Primary: Visual Analogue Scale (VAS) — 5.4 score on a scale
N/A N=58 Observational, Post Market Study in Treating Chronic Upper Extremity Limb Pain
Upper Limb · Pain
Primary: Percentage of Implanted Subjects Who Respond to DTM SCS Therapy at 3-months — 100 percentage of individual responder