N/A N=95 Pelvis RCT: Impact of Surgery on Pain in Lateral Compression Type Pelvic Fractures
LC Pelvic Fracture
Primary: Posttreatment Pain — 5.3; 6.2; 4.2; 5.6 scores on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=131 Vertebroplasty for the Treatment of Fractures Due to Osteoporosis
Spinal Fractures · Osteoporosis
Primary: Back-specific Functional Status Using Roland-Morris Disability Questionnaire (RDQ) Scale at 1 Month — 12.0; 13.0 units on a scale — p=0.49
N/A N=60 Comparison of Treatments of Osteoporotic Compression Fracture Using Rigid Brace, Soft Brace, and no Brace
Compression Fracture
Primary: Oswestry Disability Index (ODI) at 12 Weeks — 35.95; 33.54; 37.83 units on a scale
N/A N=134 CAFE Study - Cancer Patient Fracture Evaluation
Cancer · Spinal Fractures
Primary: The Functional Status, as Measured by the Roland-Morris Disability Questionnaire (RDQ) at 1 Month — 17.6; 18.2; 9.1; 18.0 score on a scale
Phase 4 N=84 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures
Vertebral Compression Fracture
Primary: Comparison of 3 Month ODI Score Between Unipedicular and Bipedicular Kyphoplasty Groups — 15; 14 units on a scale — p=0.85
Phase 4 N=1,366 VERtebral Fracture Treatment Comparisons in Osteoporotic Women
Postmenopausal Osteoporosis
Primary: Proportion of Participants With New Vertebral Fractures — 28; 64 Participants (with at least one event) — p=0.000094
Phase 3 N=108 Tapentadol IR vs Oxycodone IR vs Placebo in Acute Pain From Vertebral Compression Fracture Associated With Osteoporosis
Back Pain
Primary: Sum of Pain Intensity Difference Over 3 Days (SPID72) — 139.0; 129.4; 114.2 Scores on a scale
N/A N=350 Evaluation of Outcomes for Quality of Life and Activities of Daily Living for BKP in the Treatment of VCFs
Compression Fracture of Vertebral Body · Osteoporosis · Cancer
Primary: Back Pain Change From Baseline at 3 Months — 8.7; 2.7; -6.0 units on a scale
Phase 3 N=1,262 Denosumab Fracture Intervention Randomized Placebo Controlled Trial in Japanese Patients With Osteoporosis
Osteoporosis
Primary: Incidence of New or Worsening Vertebral Fractures in Osteoporotic Subjects Treated With Denosumab Compared to Placebo — 3.6; 10.3; 7.2 Vertebral fractures — p=0.0001
Phase 3 N=300 The Kiva® System as a Vertebral Augmentation Treatment
Spinal Fractures · Fractures, Compression · Back Injuries
Primary: Proportion of Participants With Study Success — 120; 123 participants
N/A N=9 Computed Tomography for Evaluating Supination-external Rotation Type Ankle Fractures
Supination-external Rotation Ankle Fractures
Primary: Medial Clear Space Distance in the Ankle Joint — 1.41 mm
N/A N=141 Build Better Bones With Exercise
Osteoporotic Fractures · Spinal Fractures
Primary: Feasibility of Recruitment and Retention — 66; 64 Participants
Phase 2 N=35 Stereotactic Body Radiation Therapy and Vertebroplasty in Treating Patients With Localized Spinal Metastasis
Metastatic Cancer · Pain · Unspecified Adult Solid Tumor, Protocol Specific
Primary: Pain Response as Measured by VAS at 3 Months — 8; 12; 1 Participants
Phase 3 N=712 Effect of Teriparatide Compared to Risedronate on Back Pain in Women With a Spine Fracture Caused by Osteoporosis
Osteoporosis, Postmenopausal · Back Pain · Spinal Fracture
Primary: Number of Participants Responding With at Least a 30% Reduction in 24-Hour Worst Back Pain Severity at the 6-Month Endpoint — 206; 193; 142; 143 participants — p=0.642
Phase 4 N=13 Fracture (FX) Improvement With Teriparatide: FiX-IT Study
Osteoporosis · Atypical Femoral Fracture
Primary: Radiologic Evidence of Bone Healing — 12.6; 11.2; 15.4; 13.2 units on a scale
N/A N=89 Study of Effect of Exercise With Osteoporosis and Vertebral Fracture
Osteoporosis · Vertebral Fracture
Primary: Time Used to Walk 20 m at Maximal Speed. — 14.9; 14.7; 13.4; 15.2 Seconds
N/A N=30 Wrist Fracture Evaluation With a Desktop Orthopedic Tomosynthesis System
Fracture
Primary: Sensitivity — 96.7 percent of scans with a fracture
N/A N=20 Reduction and Fixation of Metatarsal Neck Fracture by Metaizeau's Technique
Displaced Metatarsal Neck Fracture
Primary: Time of Union — 5.8 weeks
N/A N=12 Study to Investigate the Long Term Survivorship of Coflex
Spinal Fractures
Primary: Number of Participants With Radiographic Analysis of Evidence of Fracture or Healing Based on CT Scan — 8 Participants
N/A N=81 Safety and Efficacy Study of Treatment of Pathological Fractures in Humerus
Humerus Fracture Metastatic Bone Disease
Primary: Change in Pain — -52.7 units on a scale — p=0.615
Phase 3 N=122 Effect of Teriparatide on Hip Fracture Healing
Femur Neck Fracture
Primary: Percentage of Participants With No Revision Surgery at 12 Months After Internal Fixation of a Low-Trauma Femoral Neck Fracture — 87; 86 percentage of participants
Phase 2 N=61 Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury
Spinal Cord Injury · Bone Loss · Osteoporosis
Primary: Bone Mineral Density BMD of the Total Hip as Assessed by DXA. — 0.66; 0.63; 0.64; 0.65 g/cm^2 — p=0.84
N/A N=33 Use of a Reinforced Injectable Calcium Phosphate Bone Cement in the Treatment of Tibial Plateau Fractures
Tibial Fractures
Primary: Duration of Time the Patient Was in the OR as a Measure of Effectiveness of the Treatment — 107.0 Minutes
Phase 2 N=35 PTH(1-34) and Pelvic Fracture Healing - a Randomized Controlled Trial
Osteoporotic Fractures
Primary: Number of Participants With Evidence of Cortical Bridging for Fracture Healing — 9; 8 Participants
Phase 3 N=39 Second Study of the Effect of Teriparatide on Hip Fracture Healing
Femur Neck Fracture
Primary: Percentage of Participants With No Revision Surgery at 12 Months After Internal Fixation of a Low-Trauma Femoral Neck Fracture — 74; 93 Percentage of participants
N/A N=239 Clinical Trial Comparing Decompression With and Without Coflex™ Interlaminar Technology Treating Lumbar Spinal Stenosis
Spinal Stenosis
Primary: Change in ODI From Baseline to 24 Months — -19.0; -22.5 percentage points
N/A N=100 Sagittal Plane Shear Index for Planning Lumbar Stenosis Surgery
Lumbar Spinal Stenosis · Spondylolisthesis
Primary: Proportion of Surgical Plans Recorded Prior to the SPSI Report That Are Altered After Integration of SPSI Into the Surgical Planning — 47; 22; 6 Surgical plans
N/A N=34 Comparative Evaluation of External Chest Wall Fixator Treatment Effectiveness in Patients With Rib Fractures
Rib Fractures · Trauma
Primary: Pain Level — 1.79; 2.85 score on a scale
N/A N=12 Effect of High Doses of Radiation on Bone Structure and Metabolism
Malignant Bone Tumors
Primary: Change in Bone Mineral Density (Tb. BMD) — 4.5; -39.3; -8.7; -54.7 mg/cm^3
N/A N=60 Sacroiliac (SI) Screws: The Effect of SI Screw Removal on Patient-Reported Pain and Functional Outcomes
Sacroiliac Joint · Pain · Pelvis
Primary: Post-operative Pain Within 6 Months After Iliosacral Screw Removal Using the Brief Pain Inventory (BPI) — 3.7; 4.7 units on a scale — p==0.57