N/A N=19 Frequency of Denture Cleanser Use and Denture Cleanliness
Denture Cleansers
Primary: Change From Baseline in Aerobic Bacteria Microbial Count on Day 7 — -1.78; -1.20 log10(CFU[colony forming unit]/disc+1) — p=0.0144
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=49 A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Partial Denture Wearers
Gingivitis
Primary: Mean Bleeding Index (BI) at Week 12 — 0.45; 0.76 Score on a scale — p=<0.0001
N/A N=31 Oral and Dermal Tolerability Clinical Study of an Experimental Denture Wipe
Denture Cleansers
Primary: Proportion of Participants Experiencing or Reporting Treatment Emergent (TE) Oral Adverse Events (AEs) on or Before 14 Days of Use — 0.039; 0.013 Proportion of…
N/A N=53 Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Edentulous Jaw · Edentulous Mouth
Primary: Change From Baseline in Patient Comfort for as Assessed by Numerical Scale. — 0.99; 1.16 units on a scale
N/A N=38 Assessing Effects of a Denture Gel on Gum Abrasions
Gum Injury
Primary: Abrasion Assessment (Number) — 3.65; 4.11 number of abrasions
Phase 3 N=119 To Evaluate Oral Health and Quality of Life Associated With Use of a Denture Adhesive
Denture Retention
Primary: Gum Health Analysis by Change From Baseline in Overall Mean Scores of Participant Responses to the Gum Comfort Questionnaire After 12 Weeks — 4.1; 4.5; -0.6; -0.4 Score…
Phase 1 N=48 The Effect of Palatal Brushing on Denture Stomatitis
Denture Stomatitis
Primary: Palatal Inflammation — 3; 3; 2.5; 2 units on a scale — p=<0.0001
N/A N=23 A Bite Force Study Comparing Two New Test Adhesives With Currently Marketed Denture Adhesive
Denture Retention
Primary: Area Over Baseline Over 12 Hours (AOB0-12) for Test Adhesive 1 Versus (vs.) No Adhesive — 2.09; 1.43 lbs — p=0.1770
N/A N=86 Whitening Efficacy of Dentifrice Containing 10% High Cleaning Silica, 0.5% Sodium Phytate and 0.5% Sodium Pyrophosphate
Tooth Bleaching
Primary: Lobene Stain Index of Stain Extent Scores 4 Weeks After Dentifrice Use — 1.35; 1.64 score on a scale
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
N/A N=83 Evaluation of a Experimental Denture Adhesive to Prevent Food Ingress
Denture Retention
Primary: Combined Mass of Peanuts (Gram) (From Upper and Lower Dentures) for Reference Denture Adhesive and on no Adhesive Use — 0.06; 0.08 gram (g) — p=0.0987
Phase 2 N=123 A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices
Oral Hygiene
Primary: Change From Baseline in Overall Macpherson Modification of the Lobene Stain Index (MLSI) at 8 Weeks. — -0.32; -0.47; -0.38; -0.40 Score on a scale — p=0.6499
Phase 4 N=48 A Study to Investigate Food Occlusion Efficacy of a Denture Adhesive in Denture Wearers
Denture Retention
Primary: Food Occlusion Analysis of Combined Mass of Peanuts Under Combined Maxillary (Upper) and Mandibular (Lower) Dentures — 5.56; 29.13 Milligrams (mg) — p=<0.0001
Phase 3 N=105 Clinical Study to Examine Brushing on Dental Implants
Gingival Diseases
Primary: Mombelli Plaque Index (mPI) for Natural Teeth — 1.96; 1.82 units on a scale — p=0.05
Phase 4 N=57 The Efficacy of Stabilized Chlorine Dioxide Rinse as a Chemical Adjuvant for Treatment of Per-implant Mucositis
Peri-implant Mucositis
Primary: Global Probing Depth — 2.37; 2.64 mm — p=0.28
Phase 2 N=28 Evaluating Commercial Anti-Plaque Products and Oral Rinse
Dental Plaque
Primary: Plaque Index — 2.63; 2.65; 1.23 Units on a scale — p=0.05
Phase 2 N=319 Clinical Efficacy Evaluation of Three Dentifrices
Gingival Inflammation and Bleeding · Dental Plaque
Primary: Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy — 2.081; 2.094; 2.092; 1.996 units on a scale
N/A N=227 A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal
Tooth Stain
Primary: Lobene Stain Index Composite Score at Day 15 — 2.568; 1.909; 1.575 units on a scale — p=<0.001
N/A N=44 A Clinical Bite Force Study of Two Marketed Adhesives Against no Adhesive
Denture Retention
Primary: Area Over Baseline Over 12 Hours (AOB0-12) for the Incisal Bite Force (Positive Control Adhesive Versus [vs.] Negative Control) — 4.78; 2.03 lbs — p=<.0001
Phase 3 N=43 A Clinical Study to Evaluate the Maximum Maxillary Bite Force (BF) When Using Two Novel Denture Adhesives Compared to Using No-Adhesive
Denture Retention
Primary: Area Over Baseline Over 12 Hours (AOB 0-12) to Compare Maximum Incisal Bite Force — 0.87; 0.69; 0.89; 0.59 lbs — p=0.037
N/A N=160 A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching
Dentin Sensitivity · Oral Hygiene
Primary: Adjusted Mean VITA Shade Score at 24 Weeks After Tooth Bleaching — 12.00; 12.06 score on a scale — p=0.9141
Phase 3 N=25 Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.
Gingival Diseases
Primary: Plaque Index — 2.45; 2.22; 2.54; 2.56 Units on a scale — p=0.05
N/A N=48 A Study to Investigate a Method to Measure Food Occlusion by Denture Adhesives in Denture Wearers
Denture Retention
Primary: Mass of Peanuts Under Combined Maxillary and Mandibular Dentures (Denture Adhesive Applied Per Conventional Pattern) — 0.01184; 0.00944; 0.07853 Grams
Phase 3 N=24 Investigate Oral Bacteria in Adult Population
Oral Bacteria
Primary: Antimicrobial Species in Plaque(Actinomyces) — 0.023; 0.3881; 0.0538 log CFU (Colony forming units) — p=0.05
N/A N=220 Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices
Extrinsic Dental Stain · Oral Hygiene
Primary: Overall Modified Lobene Stain Index (MLSI) Mean Score at Week 4 — 1.38; 1.43; 1.42; 1.38 Score on a scale — p=0.2681
Phase 3 N=22 Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse
Dental Plaque
Primary: Plaque Index — 3.31; 3.31; 2.91 Units on a scale — p=0.05
N/A N=50 Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
Dental Caries · Denture, Partial, Removable
Primary: Mineral Loss ΔZ — 235; 774 vol% * μm]
N/A N=29 Intra Oral Kinetics of Fluoride Containing Dentifrices
Tooth Erosion
Primary: Concentrations of Fluoride Ions in Saliva 60 Minutes Post Brushing Prior to Administration of the Orange Juice or De-ionised Water Rinse — 0.23; 0.23; 0.15 parts per…
Phase 3 N=23 Clinical Study to Evaluate Dental Plaque
Gingival Diseases
Primary: Dental Plaque Index — 2.48; 2.42 Units on a scale — p=0.05
N/A N=200 A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Plaque
Primary: Plaque Index Score Per Participant at 6 Months — 2.12; 2.70; 2.23; 2.84 score on a scale — p=<0.0001