30 closest matches · ranked by relevance
Tardive Dyskinesia
Primary: Change in Total Motor Abnormal Involuntary Movement Scale (AIMS) Score From Baseline to Week 12 Using a Mixed Model For Repeated Measures (MMRM) — -1.4; -2.1; -3.2; -3.3…
Dyskinesias · Movement Disorders · Parkinson Disease
Primary: Gaitmat Stance Measurements (AUC) — 4.48; 10.8; 20.9; 2.8 Root Mean Square of Velocity*Minutes
Parkinson Disease
Primary: Unified Dyskinesia Rating Scale (UDysRS) — -4.2; -7.0 score on a scale
Tardive Dyskinesia
Primary: Change in Centrally Read Abnormal Involuntary Movement Scale (AIMS) Score From Baseline to Week 12 Using Mixed Model Repeated Measures (MMRM) Analysis — -3.0; -1.6 units…
Parkinson Disease · Movement Disorders · Central Nervous System Diseases
Primary: Change From Baseline to Endpoint of 12 Weeks in the 3-day Average of Awake Time Per Day Spent in the "Off" State — -0.4; -1.3; -1.6; -1.7 hours/day — p=0.753
Parkinson Disease · Dyskinesia, Drug-Induced
Primary: Peak Unified Dyskinesia Rating Score (UDysRS) — 10.9; 10.8; 13.2 score on a scale — p=0.63
Cerebral Palsy, Dyskinetic
Primary: Change From Baseline in the Movement Disorder-Childhood Rating Scale (MD-CRS) Part II Total Score (Movement Disorder Severity, Centrally Read) at Week 15 — -0.4; -1.5…
Parkinson's Disease · Dyskinesia
Primary: Responder Rate Based on Unified Parkinson's Disease Rating Scale (UPDRS) Items 32 and 33 at Week 12 — 30.4; 33.2 percentage of subjects
Tardive Dyskinesia
Primary: Part A, B, and C: Number of Participants With Treatment-Emergent AEs (TEAEs), Serious TEAEs, Severe TEAEs, Drug-Related TEAEs, and TEAEs Leading to Withdrawal — 269; 23…
Parkinson's Disease
Primary: Efficacy of DHA - Change in Blood ng/dL Levels — 102.18; -13.20 ng/dL - Blood
Tardive Dyskinesia
Primary: Abnormal Involuntary Movement Scale (AIMS) Dyskinesia Total Score Change From Baseline at Week 6 — -2.5; -3.3 units on a scale — p=0.2966
Parkinson's Disease
Primary: The Investigators Will Assess Effect Size With Each Scale for Detecting Change From Baseline and Change Between Amantadine and Placebo; Allowing Assessment of…
Parkinson Disease
Primary: Change in Average Daily Hours of ON-time Without Troublesome Dyskinesia With Mesdopetam Compared to Placebo as Assessed With 24-hour Patient Home Diaries From Baseline…
Dystonia-Parkinsonism, Adult-Onset · Parkinson Disease
Primary: Burke-Fahn-Marsden Dystonia Rating Scale — 3.5 units on a scale — p=<0.001
Dyskinesia · Parkinson's Disease
Primary: Least Squares Mean Dyskinesia Severity Area Under the Curve (AUC) Score As Assessed By Modified Movement Disorder Society-Unified Dyskinesia Rating Scale (MDS-UDysRS)…
Parkinson's Disease · Dyskinesia
Primary: Change From Baseline in Diary-Based On-Time Without Dyskinesia at Week 12 — 1.6; 1.9; 1.7; 1.8 hours/day
Tardive Dyskinesia
Primary: Abnormal Involuntary Movement Scale (AIMS) Dyskinesia Total Score Change From Baseline at Week 6 — -0.1; -3.2; -1.9 scores on a scale — p=<0.0001
Tardive Dyskinesia
Primary: Change From Baseline in Abnormal Involuntary Movement Scale (AIMS) Total Score (Central Assessment) at Week 6 — -0.1; -2.3; -3.7 units on a scale — p=<0.001
Tardive Dyskinesia
Primary: Abnormal Involuntary Movement Scale (AIMS) Dyskinesia Total Score — 9.9; 9.1; 8.8 units on a scale — p=0.5880
Tardive Dyskinesia
Primary: Abnormal Involuntary Movement Scale (AIMS) Dyskinesia Total Score Change From Baseline at Week 6 — -0.3; -3.4 units on a scale — p=<.0001
Dyskinesia · Levodopa-Induced Dyskinesia (LID) · Parkinson's Disease (PD)
Primary: Change in the Unified Dyskinesia Rating Scale (UDysRS) Total Score — -6.3; -20.7 units on a scale — p=<0.0001
Parkinson's Disease (PD)
Primary: Mean Change From Baseline to Week 12 in Unified Dyskinesia Rating Scale (UDysRS) Total Score — -2.33; -17.37 units on a scale — p=<0.0001
Oral Dystonia · Tardive Dystonia
Primary: Mean Global Dystonia Rating Scale Score as Measured by Blinded Rater — 3.80; 3.57; 3.71 units on a scale
Huntington Disease · Chorea
Primary: Change From Baseline in Mean Unified Huntington's Disease (HD) Rating Scale Total Maximal Chorea (UHDRS TMC) Score — -2.4 score on a scale — p=0.27
Cerebral Palsy
Primary: Oxygen Consumption (ml/kg/Min) — 14.82; 16.75; 28.77 ml/kg/min
Dyskinesia · Levodopa Induced Dyskinesia · Parkinson's Disease
Primary: Change in the Unified Dyskinesia Rating Scale (UDysRS) Total Score From Baseline to Week 8 — -6.7; -12.3; -17.9; -16.7 units on a scale — p=0.0051
Leg Spasticity
Primary: Least Squares Mean Change From Baseline to Week 4 in the MAS Score in the Gastrocnemius-soleus Complex (GSC) (Knee Extended) — -0.6; -0.8; -0.5 units on a scale…
Nervous System Disorders
Primary: Change From Baseline in MAS Score in the Primary Targeted Muscle Group (PTMG) — -0.3; -1.2; -1.4 units on a scale
Equinovarus; Acquired
Primary: Self-Selected Velocity (SSV) — 0.41; .48; 0.48; 0.52 m/s
Parkinson's Disease · Motor Fluctuations
Primary: The Primary Objective of This Study is to Explore the Efficacy and Tolerability of DM-1992 Compared to a Standard CD/LD IR Formulation as Measured by Percent "OFF" Time…