Clinical Trial Search

Primary: Feasibility of Accurately Delivering TMS During the Task of Writing as Measured by Number of Participants Who Completed the TMS Sessions — 12; 12; 11 Participants

Primary: Change From Baseline in Global Rating of Change at Posttest (Day 5) — 1.3; 1.2 units on a scale

Primary: Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) — -3.0; 0.25; -2.9; -1.5 units on a scale

Primary: Cortical Silent Period — 9; 1.61 milliseconds

Primary: Toronto Western Spasmodic Torticollis Rating Scale (TWSTR) Sum Score — -6.00; -3.23 units on a scale

Primary: Adverse Response to rTMS — 0; 0 Participants

Primary: Physician Global Perception of Change - Blinded Rater 1 — 1; 1; 1; 4 Participants

Primary: Dystonia Severity as Assessed by the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) — 13; 17 scores on a scale

Primary: Cognitive Assessment Using MoCA Version 7.1 Scores — 25.45; 27 units on a scale

Primary: Using a Patient Rated Subjective Scale (Visual Analogue Scale), Change From Baseline With Botulinum Toxin Therapy Plus Occupational Therapy Compared to Botulinum Toxin…

Primary: Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) — 17; 16.6; 17; 15.8 score on a scale — p=0.691

Primary: Burke-Fahn-Marsden Dystonia Rating Scale — 3.5 units on a scale — p=<0.001

Primary: Change From Baseline in Burke-Fahn-Marsden Dystonia Rating Scale — 14.7 change in points on a scale

Primary: Unified Spasmodic Dysphonia Rating Scale (USDRS) — 2.5; 3.75 units on a scale — p=0.025

Primary: The Toronto Western Spasmodic Rating Scale (TWSTRS) Movement Scores Measured Before DBS Surgery (Baseline) and at 12 Months — 33.5 TWSTRS total score change

Primary: Change in JRS Severity Score — -1.8; -0.1 Change in score

Primary: Stop Signal Reaction Time (SSRT) — 249; 245 milliseconds — p=0.49

Primary: Note Errors (Related to Errors in Duration) — 8.20; 5.79 msec — p==0.06

Primary: Percentage Change in the Time to Complete the Nine-hole Peg Test (9-HPT) to Immediate Post-intervention — 7.37; -0.15; -4.68 Percentage change in 9HPT time

Primary: Change From Baseline in Arm Function Based on Motor Activities Log (MAL-O) — 1.52; 1.79 units on a scale

Primary: Pre- and Post-injection Toronto Western Spasmodic Torticollis Rating Scale(TWSTRS): Global Clinical Impression Scale (GCI); Visual Analog Scale(VAS)

Primary: Gray Matter Volume Biomarkers of 6 Month Prognosis as Measured by Voxel Based Morphometry - Within Group Comparison — 4.18; 3.27; 3.85; 3.76 peak voxel z-score

Primary: Change From Baseline in Observed Total Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) Score at Week 4 of Treatment Cycle 1 — 40.4; 41.5; 39.6; -10.3 Scores…

Primary: Difference in the 6 Week Post Injection Patient Global Impression of Improvement Scale (PGIS) Between Flexors Along and Flexors Plus Extensors Groups. — 1.2; 2.2 score…

Primary: Fugl-Meyer Upper Extremity Assessment Part A — 4.13; 5.38; 0.88 score on a scale — p=<0.0001

Primary: Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) — 28; 20.1 total score on a scale

Primary: Geometric Ratios of Log-transformed Transit Time — 1.19; 1.07; 0.79; 0.72 dimensionless ratio — p=.059

Primary: Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III: Motor Examination Score — 3.25 Score on a scale

Primary: Tremor Model Accuracy — 24; 21 Normalized RMSE (%)

Primary: Regions With fMRI Differences Between ET and Controls — 139; 93; 85; 74 Number of Activated Voxels