Phase 4 N=2 Tissue Sealant Use in LASIK Enhancement Surgery
Epithelial Ingrowth
Primary: Slit Lamp Examination for Presence of Epithelial Ingrowth Under LASIK Flap — 0 Eyes
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=44 Epidermal Grafting in Wound Healing
Ulcer · Skin Ulcer · Wounds and Injuries
Primary: Number of Wounds With Complete Healing — 9; 13; 16; 20 number of wounds — p=0.366
N/A N=142 Ab Interno Gelatin Stent With Mitomycin C Using Targeted Supra-tenon's Placement
Glaucoma
Primary: Postoperative Intraocular Pressure Changes Between Targeted Supratenon's Placement of XEN-45 Gelatin Stent and Nontargeted Placement. — 20; 15 Participants
N/A N=129 Changes in Corneal Endothelial Cell Density After Transscleral ab Interno Glaucoma Gel Stent Implantation
Glaucoma · Endothelial Cell Loss, Corneal
Primary: Endothelial Cell Count Change — 2; -1; 0; -4 % change compared to baseline
Phase 2 N=10 A Study of the KIO-201 (Ocular Bandage Gel) for Improving Persistent Corneal Epithelial Defects
Persistent Corneal Epithelial Defect
Primary: Percentage of Patients Achieving Corneal Healing (<0.5 mm2 Lesion Size) of the Persistent Corneal Epithelial Defect at 4 Weeks — 5 Participants
N/A N=15 Neo-nervegenesis in Inguinal Hernia Implant ProFlor
Inguinal Hernia
Primary: Ingrowth of Newly Formed Nervous Elements Within Hernia Implant ProFlor — 999.75; 1044; 2094 μm^2 — p=0.028
Phase 4 N=40 Comparison of Excision Versus Punch Incision in the Treatment of Epidermal Cysts
Epidermal Cyst
Primary: Number of Participants With Cyst Recurrence — 3; 2 participants
N/A N=37 Endothelial Bleb Response With Toric Lenses
Ametropia
Primary: Endothelial Bleb Areas on Cornea: Session A- Open Eye — 0.1; 2.0; 0.2; 2.1 Percent Difference of Bleb Area
Phase 2 N=1 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts
Ectropion · Skin Neoplasms
Primary: Graft Size Change — 10 percent change in graft
Phase 1 N=165 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Corneal Epithelial Defect · Diabetic Retinopathy · Penetrating Keratoplasty
Primary: Patients With Corneal Epithelial Healing Time Within 14 Days — 78; 73 participants
Phase 4 N=46 Esthetic Outcomes Following Immediate Implant Combine With Soft Tissue Augmentation
Dental Implant · Immediate Dental Implant · Soft Tissue Augmentation
Primary: Change in Ridge Dimension — -1.65; -1.87; -1.44; -1.37 millimeters (mm)
N/A N=34 Study of Cellutome System for Treatment of Individual Lesions in EB Pts
Epidermolysis Bullosa
Primary: Percentage of Grafts Successfully Treated — 78 Percentage of grafts
N/A N=35 Vitreous Inflammation in Standard and Heavy Silicone Oil
Vitreous Inflammation
Primary: Vitreous Prostaglandin E2 Levels — 369.38; 869.16 pg/mL
N/A N=30 Impact of Soft Contact Lenses on Lid-Parallel Conjunctival Folds
Lid-Parallel Conjunctival Folds
Primary: Lid-Parallel Conjunctival Folds (LIPCOF) — 1.95; 1.75; 1.70; 1.40 Score
N/A N=10 Ologen (OculusGen)-Phacotrabeculectomy Historical Control Study in India
Glaucoma · Cataract
Primary: Preoperative and Postoperative Intraocular Pressure — 20.1; 9 mm Hg — p=0.01
N/A N=5 Safety and Effectiveness of Collagen-phosphorylcholine Bioengineered Cornea in Patients Requiring Lamellar Keratoplasty
Corneal Ulcer · Leukoma
Primary: Incidence of Treatment-Emergent Adverse Events — 0 events
N/A N=60 Platelet Rich Fibrin vs Sub Epithelial Connective Tissue and Coronally Advanced Flap Alone in Gingival Recession
Gingival Recession
Primary: Gingival Thickness — 1.97; 1.95; 1.39 millimeter
N/A N=21 Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty
Corneal Edema Secondary to Corneal Endothelial Dystrophy
Primary: Best Spectacle Corrected Visual Acuity (BSCVA) — 1; 3; 7; 9 Participants
Phase 2 N=7 Gene Transfer for Recessive Dystrophic Epidermolysis Bullosa
Epidermolysis Bullosa Dystrophica · Epidermolysis Bullosa
Primary: Number of Wounds by Healing Category Per Investigator Visual Assessment — 35; 5; 2; 28 wounds
Phase 4 N=131 Extension Study to Gather Data on Effect of Macugen on the Corneal Endothelium
Age-Related Macular Degeneration · Retinal Vein Occlusion · Diabetic Macular Edema
Primary: Change From Baseline in Mean Endothelial Cell Density — -35.86 cells/millimeter squared
N/A N=40 Sutureless Cryopreserved Amniotic Membrane Graft (ProKera) and Wound Healing After Photorefractive Keratectomy
Corneal Wound Healing
Primary: Number of Days to Complete Re-epithelialization — 4.6; 4.1 days to complete re-epithelialization
N/A N=42 Evaluation of the Treatment of Multiple Gingival Recession Using Modified Coronally Advanced Tunnel With Subepithelial Connective Tissue Graft Depending on the Positioning of the Graft
Gingival Recession
Primary: Percent Change in Gingival Recession (Mean Root Coverage, MRC) — 95.00; 96.00 Percent change (%)
Phase 4 N=17 Treatment of Post-Extraction Dehisced Socket - A Case Series Study
Tooth Loss
Primary: Bone Volumetric Reduction From Baseline to 20 Weeks Post-extraction — 73.26 mm3
N/A N=44 Expression of Angiogenic Biomarkers During Healing of Intra-Oral Soft Tissue Engineered Grafts
Gingival Recession
Primary: Differences in Angiogenic Biomarkers — 0.51; .69; 1.04; .67 ng/mL
N/A N=135 Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking
Keratoconus
Primary: Number of Participants With Complete Healing of Corneal Epithelial Defect at Day 3 — 20; 25 Participants
Phase 2 N=5 The Effect of Bevacizumab (Avastin) on Pterygium
Pterygium
Primary: The Area the Pterygium Enlarged or Regressed as Measured From the Limbus Before and After Subconjunctival Bevacizumab Injection. — 5.75 area in millimeters squared…
Phase 3 N=239 Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus
Progressive Keratoconus
Primary: Difference Between Treatment Groups in the Change From Baseline to Month 6 in Kmax — -0.3; 0.6 Diopters — p=0.0004
Phase 2 N=39 Safety Study of Avastin Used as Adjunctive Therapy in Pterygium Surgery
Pterygium
Primary: Number of Participants Who Had Recurrence of Pterygia up to 1 Year — 0; 3 participants
N/A N=40 Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty
Fuchs Endothelial Dystrophy · Corneal Edema
Primary: Endothelial Cell Loss — 28; 36 percentage of endothelial cell loss — p=0.10
N/A N=20 Optimizing the Ocular Surface Prior to Cataract Surgery
Corneal Dystrophy, Epithelial Basement Membrane
Primary: Change in Intraocular Lens Calculation — 1.56; 0.94 D