Clinical Trial Search

Primary: Observe Stability of Nail Polish as Evidenced by Serial Photography With Efinaconazole Application in Terms of Days — 1.5; 5; 15; 5 days of stability

Primary: Percentage of Nail Polish Disruption Using the Likert Scale — 0.6; 0 percentage of nail polish disruption

Primary: Measurement of Antifungal Activity of Loceryl Nail Lacquer — 53.6; 53.5 Milimeter

Primary: Number of Participants With Elimination of Dermatophytomas That Occur in Distal Lateral Subungual Onychomycosis (DLSO) — 19 Participants

Primary: Mycological Cure — 2 Participants

Primary: Mycological Cure — 12 Participants

Primary: Number of Participants With Local Tolerability Reactions by Severity — 54; 0; 1; 0 Participants

Primary: Efficacy Assessed by Complete Cure Rate at the End of Study (Week 52) After Treating for 24 or 48 Weeks. — 0.79; 0.78; 1.47; 0.00 Percentage of Participants

Primary: Percent of "in Label" Adherent Subjects — 85; 60 percentage of participants

Primary: Efficacy Assessed by the Percentage of Participants With Complete Cure at the End of Study (Week 52) After Treating for 24 or 48 Weeks — 1.50; 0.77; 2.96; 0 Percentage…

Primary: Primary Endpoint - Efficacy — 4 Participants

Primary: Treatment Related Adverse Events — 22; 8 Participants

Primary: Percentage of Participants With Complete Cure at the End of Study After Treating Participants for 48 Weeks — 1.18; 0.96 Percentage of participants

Primary: Number of Participants With Negative Fungal Culture — 14; 2 Participants

Primary: Nail Bed Clearing

Primary: The Proportion of Subjects Who Achieve at Least a 75% Improvement From Baseline in Total mNAPSI at Week 28. — 0.042; 0.255 proportion of subjects — p=0.00311

Primary: An Increase in Healthy New Nail Growth Free of Fungal Infection ("Clear Nail") at 12 Months Post-treatment — 5.9; 5.5 millimeters (mm)

Primary: Change From Baseline in Single-Hand Nail Psoriasis Severity Index (NAPSI)and in the Modified Target NAPSI for the Single Most Severely Affected Nail of Each Hand at Week…

Primary: Percent (%) of Toenails Attaining 3 Millimeters (mm) or More of Clear Nail Growth — 67 Percent of Toenails

Primary: Percentage of Participants Showing 10 Percent or Higher Response in Scoring Clinical Index for Onychomycosis (SCIO) Score at Week 5 — 25.6 percentage of participants

Primary: Mycological Cure — 17; 28; 16; 13 Percentage of participants — p=<0.05

Primary: Complete Cure (Completely Clear Nail and Negative Mycology) of Target Great Toenail at Week 52 — 26; 1; 373; 193 participants — p=0.001

Primary: Clinical Evidence of Complete Clearance of the Treatment-targeted Great Toenail Plus a Negative Fungal Culture at Day 360 — 2; 27 participants

Primary: Mean Percent Change of mNAPSI (Modified Nail Area Psoriasis Severity Index) at Week 36 Compared to Baseline for All Nails. — 64.1 percentage of reduction in mNAPSI score…

Primary: Percentage Change From Baseline in Nail Psoriasis Severity Index (NAPSI) After 16 Weeks of Treatment — -38.4; -46.1; -11.7 percent change — p=<0.0001

Primary: Modified NAPSI Score (Nail Psoriasis Severity Index) — 6.3; 6.0 units on a scale

Primary: The Proportion of Subjects in the Intent-to-treat Population With Complete Cure, Defined as Clinical AND Mycological Cure, at Week 48 — 17; 19; 22; 18 Participants

Primary: Complete Cure of Onychomycosis at Week 48. — 8; 20; 15; 7 Participants — p=0.005

Primary: The Percentage of Participants Who Achieve Effective Treatment at Week 52 — 54; 38; 29; 21 Percentage of participants — p=<0.001

Primary: Complete Cure (Completely Clear Nail and Negative Mycology) of Target Great Toenail at Week 52 — 36; 3; 360; 202 participants — p=<0.001