Clinical Trial Search

Primary: Spirometry and Specific Airway Conductance Measured by Body Plethysmography Before and After Exercise Challenge After Randomized Administration of Either Inhaled…

Primary: Maximum Percent Fall in FEV1 After Exercise Challenge at 2 Hours Postdose Compared With Pre-exercise Baseline in Patients With Exercise-induced Bronchospasm (EIB)…

Primary: Maximum Percent Fall in Forced Expiratory Volume in 1 Second (FEV1) After Exercise Challenge at 2 Hours Post-dose in Patients With Exercise-Induced Bronchoconstriction…

Primary: Maximum Percent Fall in FEV1 After Exercise Challenge at 2 Hours Post-dose Compared With Pre-exercise Baseline in Patients With Exercise-induced Bronchospasm (EIB)…

Primary: Exercise-Induced Bronchoconstriction (EIB) Severity — 19.84; 10.94 Percentage (%) — p=0.339

Primary: Exhaled Nitric Oxide (FeNO) Level — 29.3; 23.3 ppb

Primary: Maximum Percentage Fall From Post-dose, Pre-exercise Baseline in Forced Expiratory Volume in 1 Second (FEV₁) Observed up to 60 Minutes Post-exercise Challenge — 5.45…

Primary: Maximal Inspiratory Mouth Pressure (MIP) — 9.36; 9.37; 10.55; 9.21 kPa

Primary: Maximum Post-exercise Percent (%) Fall in FEV1 — 10.57; 13.82 Percent change from baseline — p=0.009

Primary: Maximal Percentage Change From Pre-exercise Baseline Forced Expiratory Volume in 1 Second (FEV1) to the Minimum FEV1 Collected Within 60 Minutes Following the Exercise…

Primary: Maximum Percentage Fall From Post-dose, Pre-exercise Baseline in Forced Expiratory Volume in 1 Second (FEV₁) Observed up to 60 Minutes Post-exercise Challenge — 6.95…

Primary: Measured Before and 30 Minutes After Exercise in Each 1 Day Condition — 6.98; 5.96; -1.38; -.35 litres

Primary: Maximal Percent Decrease in Forced Expiratory Volume in One Second (FEV1) Following Exercise Challenge at 12 Hours (Hrs) Post Evening Dose From Pre-exercise FEV1…

Primary: Maximum Percentage Fall From Baseline in Forced Expiratory Volume in 1 Second (FEV1) up to 60 Minutes After the Exercise Challenge — 6.21; 22.38 percentage change from…

Primary: Maximal Percent Change in Forced Expiratory Volume in 1 Second (FEV1) Following Exercise Challenge at Week 4 — -9.5; -12.7 Percent change — p=0.021

Primary: Airway Blood Flow Response to Albuterol — 2.85; -1.43; 17.93; 4.03 μl/min/ml

Primary: Central and Peripheral Elastance — 391; 461; 587; 334 cmH2O/L

Primary: Maximum Percent Fall in Forced Expiratory Volume in 1 Second (FEV1) After Exercise Challenge at 2 Hours Postdose — 15.35; 20.00 Percent fall in FEV1 — p=0.020

Primary: Change in Percent of Predicted Peak Expiratory Flow Rate (PEFR) at t15 — 59.56; 52.45 percentage of predicted

Primary: Percentage of Participants With Maximum Heart Rate Increase During Exercise in Part 1 of the Study — 20.00; 16.0 Percentage of participants

Primary: Change in 6-minute Walk Test Distance (6MWD) — 46.5; 23.2 Meters

Primary: Forced Expiratory Volume at One Second - FEV1 % Predicted — 91.4; 93.4 % predicted — p=.10

Primary: Maximum Oxygen Consumption (VO2max) — 26.4 ml/kg/min

Primary: Tidal Nitric Oxide — 18.7 ppb

Primary: Asthma Control Test — 19.3; 19.8; 19.1; 19.6 units on a scale — p=0.8

Primary: Maximum Percent Drop From Pre-allergen Baseline in Forced Expiratory Volume in 1 Second (FEV1) for Late-Phase Asthma Response (LAR) at Screening — 27.19; 20.47 percent…

Primary: Change in Pulmonary Asthma Score (PAS) — 0.9; 0.4 mean PAS score

Primary: Percentage Change in the Ratio of Mean-normalized Perfusion Within Ventilation Defective Regions Relative to Outside — -17.8 percentage

Primary: Spirometry, Percentage Change in FEV1 From Baseline — -1.0; -4.8; -2.2; -7.4 percentage change in FEV1 from baseline — p=<0.05

Primary: Number of Participants With 1 or More Severe Asthma Exacerbations — 186; 154 participants — p=0.036