N/A N=25 Fractional Radiofrequency for the Treatment and Reduction of Facial Wrinkles
Rhytides · Wrinkle
Primary: Subject Satisfaction — 2.8 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=66 Reliability of the Facial Wrinkle Scale in Japanese Subjects
Facial Rhytides
Primary: Inter-rater Reliability of Assessment of Facial Lines Using the 4-Point Facial Wrinkle Scale (FWS-A) — 0.653; 0.637; 0.647; 0.654 Kappa statistics
N/A N=49 Prospective Pellevé™ Neck Wrinkle Study
Facial and Neck Rhytides
Primary: Change in Neck and Facial Wrinkles Using the Fitzpatrick Wrinkle Assessment — 74 percentage of participants
N/A N=15 Clinical Evaluation of Fractional Radiofrequency for the Treatment and Reduction of Facial Wrinkles
Rhytides · Wrinkle
Primary: Change in Facial Wrinkles at 12 Weeks Post Final Treatment Compared to Baseline — -0.10 units on a scale
Phase 4 N=30 Emervel for the Correction of Lower Face Wrinkles & Folds
Nasolabial Folds · Marionette Lines · Wrinkles
Primary: Number of Subjects With Naturalness of Expression in Motion (2D Video) — 30 Participants
Phase 3 N=121 Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin®) in Treatment of Expression Wrinkles in the Upper Third of the Face
Skin Aging
Primary: Treatment Success — 89.08 % of participants
N/A N=40 Safety and Efficacy of Single Therapy Versus Double and Triple Therapy of the Pellevé™ Wrinkle Treatment System for the Treatment of Moderate Facial Wrinkles
Appearance of Facial Wrinkles
Primary: Fitzpatrick Wrinkle Assessment — 1.0; 1.5; 1.1 units on a scale, change in Fitzpatrick
Phase 4 N=20 Study of Restylane and Perlane in the Correction of Peri-Oral Wrinkles
Peri-oral Wrinkles
Primary: Local and Systemic Adverse Events — 100 percentage of participants
Phase 4 N=101 Prospective Evaluation of Facial Cosmetic Procedures
Cosmetic Techniques
Primary: Patient Satisfaction With Validated FACE-Q Aesthetics Survey — 28.0; 24.0; 36.0; 36.0 score on a scale
N/A N=117 Investigation of the Effectiveness and Safety of MRZF111 in the Treatment of Décolleté Wrinkles
Décolleté Wrinkles
Primary: Responder Rate for Décolleté Wrinkles According to the Merz Aesthetics Scale (MAS)-At Rest Scale as Assessed by the Blinded Live Rater — 71.8; 83.7; 73.5 percentage of…
Phase 3 N=42 Cryo-Touch II for the Treatment of Wrinkles
Facial Wrinkles
Primary: Number of Participants With Effectiveness and Safety Success — 30; 41 participants
N/A N=10 Fractional Radiofrequency for the Treatment and Reduction of Acne Scars and Wrinkles
Acne Scars - Mixed Atrophic and Hypertrophic · Wrinkle
Primary: Overall Wrinkle Improvement Assessed by the Fitzpatrick Wrinkle and Elastosis Scale (FWES) at 12 Weeks Post-Final Treatment — 5.97; 5.78 units on a scale
N/A N=24 Confirmatory Study: Assessing the Efficacy and Safety of the AcusMu Microneedle Patch in Treating Periorbital Wrinkles
Wrinkle
Primary: Proportion of Participants With Improvement in Periorbital Wrinkles From Baseline — 10; 2; 8; 2 Participants
N/A N=51 TriActive+ Radiofrequency (RF) for Non-Invasive Treatment of Wrinkles and Rhytides
Wrinkles · Rhytides
Primary: Changes to the Surface by Visual and Photographic Analysis. — 41 participants
Phase 3 N=26 Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A
Wrinkles
Primary: Posttreament Results of Chemical Peel if Botox A is Added as Pre-treatment — 1; 2 Units on a wrinkle severity scale — p=.002
N/A N=25 TriActive+ Radiofrequency (RF) for Non-invasive Treatment of Wrinkles & Rhytides
Wrinkles · Rhytides
Primary: Fitzpatrick Classification of Wrinkling and Degree of Elastosis. — 5.6; 5.56; 5.36; 5.32 Fitzpatrick Classification Scale
N/A N=124 Evaluation of the Efficacy and Tolerance of a Light Therapy Mask on Mild to Moderate Brown Spots and Moderate to Severe Facial Wrinkles
Skin Aging
Primary: Global Wrinkling - Change From Baseline to Week 12, Averaged Expert Grader Scores — 0.18; 0.30 Units on a scale — p=<0.001
Phase 2 N=50 Safety and Efficacy Study of Isolagen TherapyTM in Treatment of Facial Wrinkles and Creases
Facial Wrinkles and Creases
Primary: Change in Subject Assessment of Wrinkles Compared to Baseline on Subject Wrinkle Assessment — 2; 5; 15; 11 participants
Phase 3 N=917 Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow's Feet Lines and Frown Lines
Facial Rhytides · Crow's Feet Lines · Glabellar Lines
Primary: Percentage of Responders Based on Composite Facial Wrinkle Scale Assessment of Crow's Feet Line Severity at Maximum Smile — 21.3; 20.6; 0.0 Percentage of participants
Phase 3 N=787 A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides
Facial Rhytides · Glabellar Rhytides
Primary: Percentage of Subjects With ≥2-Grade Improvement From Baseline on Both the Investigator's and Subject's Facial Wrinkle Scale (FWS) Ratings of Forehead Line Severity at…
N/A N=68 Reducing Wrinkles Around the Eyes Using the Ulthera® System
Periorbital Wrinkles
Primary: Overall Improvement in Periorbital Wrinkles and Rhytids Around the Eyes — 47; 50 percentage of participants improved
N/A N=35 Efficacy and Tolerability of SkinPen on Male and Female Subjects' Wrinkles of the Neck
Wrinkles
Primary: Assessment of Wrinkle Severity Using the Lemperle Wrinkle Assessment Scale — 3.31; 2.45 Score on a Scale — p=<0.01
N/A N=51 Clinical Study Evaluating the Safety and Effectiveness of The Tixel Fractional System in The Treatment of Periorbital Wrinkles
Wrinkle · Periorbital · Tixel 2
Primary: Percentage of Participants With Safety Adverse Events — 3.92 Percentage of Participants
Phase 4 N=154 Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds
Wrinkles
Primary: Efficacy — 77; 74; 73; 72 participantes rated improved and higher
N/A N=149 Safety and Effectiveness of Sculptra Aesthetic for Correction of Cheek Wrinkles
Cheek Wrinkles
Primary: Responder Rate Based on the Blinded Evaluator's Live Assessment of the Galderma Cheek Wrinkles Scale (GCWS) at Rest at Month 12 — 26.1; 71.6 percentage of participants…
Phase 2 N=15 Pilot Evaluation of Platelet Rich Fibrin Matrix (PRFM) for the Correction of Nasolabial Folds
Nasolabial Folds
Primary: Difference in Wrinkle Assessment Score, Between Pre-treatment and 12 Weeks Post-treatment. — 1.13 units on a scale
Phase 3 N=203 Safety and Efficacy Study of Isolagen TherapyTM in the Treatment of Nasolabial Fold Wrinkles
Bilateral Nasolabial Fold Wrinkles
Primary: Subject Wrinkle Assessment Responders — 57; 31 participants — p=.00001
N/A N=99 A Study of Octave System for Improving Lines and Wrinkles of the Décolleté
Décolleté Wrinkles
Primary: Percentage of Treated Subjects With Improvement in Lines and Wrinkles of the Décolleté at Day 90 — 62.2 percentage of subjects
Phase 3 N=218 Safety and Efficacy Study of Isolagen Therapy in the Treatment of Nasolabial Fold Wrinkles
Bilateral Nasolabial Fold Wrinkles
Primary: Subject Wrinkle Assessment Responders — 50; 19 participants — p=<.00001
N/A N=93 Safety and Effectiveness of Belotero® in Subjects With Fitzpatrick Phototypes IV Through VI
Facial Wrinkles
Primary: Percentage of Subjects With Product-related Adverse Events. — 71; 72 percentage of subjects with AEs.