30 closest matches · ranked by relevance
Hyperuricosuria · Kidney Stones
Primary: Percent Change From Baseline to Month 6 in 24-hour Urine Uric Acid (uUA) Excretion — -58.6; -36.4; -12.7 percent change — p=<0.001
Adenine Phosphoribosyltransferase Deficiency
Primary: Urinary 2,8-dihydroxyadenine Excretion — 116; 45; 13 mg/24-h — p=<.05
Type 1 Diabetes · Diabetic Nephropathy · Diabetic Kidney Disease
Primary: Change in Urine Uric Acid Concentration (Increased Solubility) by Assay — 23.81; 22.30 mg/dl
Hyperuricemia
Primary: Number of Patients With Acute Kidney Injury (AKI). — 13; 13 Participants
Cardiovascular Diseases · Heart Diseases · Hypertension
Primary: Change in Diastolic Blood Pressure by Cuff 8-10 Weeks Minus Baseline — 3.44; -0.83 mm Hg — p=0.059
Hyperoxaluria
Primary: Mean Percent Conversion of Hydroxyproline (Hyp) to Urinary Oxalate (UOx) — 12.8; 32.9; 14.8 percent converted
Hyperuricemia · Albuminuria · Type 2 Diabetes
Primary: Urinary Albumin to Creatinine Ratio (UACR) — -48.65; -15.31 Precent change
Obesity · Uric Acid Stones · Type 2 Diabetes Mellitus in Obese
Primary: Kidney Stone Size (mm^3) Determined by Non-contrast CAT Scan — 6540; 4650; 3120; 5041 mm^3
Asymptomatic Hyperuricemia
Primary: Change From Baseline in Peak Urinary Excretion of Uric Acid (UA) on Day 7 — -12.87; -13.15 milligrams (mg)
Gout
Primary: Reduction in Plasma Uric Acid to Less Than 6 mg/dL. — 17 Participants
Gout
Primary: Safety of Allopurinol — 55.1 percentage of subjects
Secondary Hyperoxaluria · Nephrolithiasis · Hyperoxaluria
Primary: Percent of Oxalate Absorption Normalized by Baseline Urinary Oxalate Excretion Over a 24 Hour Test Period — 2.84 percentage of oxalate absorption
Gout
Primary: Number and Percentage of Participants With Evidence of Chronic Ongoing Synovial-Based Inflammatory Disease at Baseline. — 63 Participants — p=0.34
IgA Nephropathy
Primary: Change in Renal Function as Measured With eGFR — 68.9; 73.2 eGFR(min/ml)
Gout
Primary: BMI — 33.4 kg/m^2
Gout
Primary: Number of Subjects With an sUA Level That is < 6.0 mg/dL — 32; 2 Number of Subjects — p=<0.0001
Parkinson's Disease
Primary: Rate of Clinical Decline — 11.116; 9.860 score per year — p=0.183
Chronic Kidney Disease
Primary: Urinary Albumin to Creatinine Ratio (uACR) (mg/g) Change From Baseline at 6 Months (Visit 8), Repeated Measures Mixed Model (MMRM) — 0.8300; 1.043; 0.8369; 0.8499 mg/g…
Gout
Primary: Plasma Uric Acid (PUA) Responder — 36; 29; 0 Participants — p=<0.001
Obesity · Metabolic Syndrome · Hyperuricemia
Primary: Percent Increase in Insulin-stimulated Glucose Uptake — 231; 162; NA; 156 % incr. in insulin-mediated gluc. uptake
Hyperoxaluria
Primary: Urinary Oxalate Excretion — 1.43; 1.04 umol/mg — p=0.007
Prehypertension · Gout · Pulse Wave Velocity
Primary: Changes in 24 Hour Blood Pressure
Joint Damage
Primary: Mean Change From Baseline to Month 24 in the Modified Sharp/Van Der Heijde Erosion Score of the Single Affected Joint — 0.16; 0.11; 0.01; 0.01 score on a scale — p=0.472
Gout · Chronic Kidney Diseases
Primary: Percentage of Participants Experiencing ≥ 1 Gout Flare During Phase 3 — 135; 165 Participants — p=<0.001
Healthy
Primary: Cmax: Maximum Observed Serum Urate Concentration — 6.6; 6.4 mg/dL
Hyperuricemia
Primary: Serum Uric Acid<6 mg/dL at Week 4 — 0; 1; 1 Participants
Obesity
Primary: Urinary Oxalate Excretion — 24 mg/day
Hyperoxaluria
Primary: Urinary Oxalate Creatinine Ratio — 68.6; 38.7; 49.6; 34.7 mg/g — p=0.027
Gout
Primary: Percentage of Participants With an sUA Level That is < 5.0 mg/dL — 82.5; 77.8 Percentage of participants
Gout
Primary: Proportion of Subjects With a Serum Urate (sUA) Level That is < 6.0 mg/dL — 68 Subjects