N/A N=17 Efficacy of Dietary Sodium Restriction of Improving Vascular Endothelial Function in Middle Aged and Older Adults
Hypertension
Primary: Improved Flow Mediated Dilation — 3.57; 6.01 percentage dilation
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=8 Bosentan and Pulmonary Endothelial Function
Pulmonary Arterial Hypertension
Primary: Acetylcholine Vascular Reactivity Response — 180 percentage of baseline
N/A N=30 Role of Flavanols In Cardiovascular Function in Healthy Aging
Aging
Primary: Cutaneous Blood Flow Response to Local Heating of the Skin. — 68; 70 percent change in mean skin blood flow
Phase 3 N=58 Inflammation and Vascular Function in Atherosclerosis
Atherosclerosis
Primary: Flow-mediated, Endothelium-dependent Vasodilation — 6.8; 8.7 percentage vasodilation
Phase 2 N=94 Inflammation and Coronary Endothelial Function
Coronary Artery Disease
Primary: Percent Change in Coronary Cross Sectional Area (CSA) From Rest to That During Isometric Handgrip Exercise (IHE) — -1.70; 2.71; -0.39; 2.04 Percent change from rest…
N/A N=47 Influence of Endothelial Function on Central and Peripheral Causes Of Exercise Impairment in Type 2 Diabetes
Type 2 Diabetes
Primary: Percent Change in Circumferential Strain Before and After Exercise at Baseline, After Vitamin C Infusion, and After Exercise Training — -24; -20; -23; -21 percentage of…
Phase 2 N=9 Vitamin D to Improve Endothelial Function in SLE
Atherosclerosis · Systemic Lupus Erythematosus
Primary: Change at Week 16 in % Flow Mediated Dilation in Those Who Did and Did Not Replete Vitamin D — 1.4; -4.2 Absolute change in % FMD — p=> 0.05
N/A N=30 Flow Mediated Dilation in Response to Black Tea
Vascular Function
Primary: Flow Mediated Dilation — 5.24; 5.02; 6.05; 5.74 percentage of change in diameter — p=0.43
N/A N=18 The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal Women
Endothelial Dysfunction
Primary: Percent Change in Brachial Artery Flow-mediated Dilation at Each Time Point — 4.11; 6.93; 5.86; 3.20 Percent Change
Phase 4 N=30 Niacin and Endothelial Function in Early CKD
Chronic Kidney Disease
Primary: Change in the Flow Mediated Dilation From Baseline — 3.07; 1.37 absolute percent change — p=0.71
N/A N=20 Vascular Endothelium Changes After Bariatric Surgery (Endothelial Progenitor Cells)
Type 2 Diabetes
Primary: Change in Late Outgrowth Endothelial Progenitor Colonies — 0.3; 0.2; 3.1; 0.1 LOEPC colonies — p=<0.05
Phase 1 N=19 Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents
Obesity · Endothelial Dysfunction · Vitamin D Deficiency
Primary: Flow Mediated Dilatation (FMD) — 9.5; 10.4 percentage increase in BAD — p=0.59
Phase 3 N=24 Targeting the Endothelial Glycocalyx to Enhance Vascular Function and Exercise-Induced Vascular Adaptations in Type 2 Diabetes
Diabetes Mellitus, Type 2
Primary: Glygocalyx Integrity - Perfused Boundary Region — 0.11; -0.16 Delta micrometers (mcm)
Phase 2 N=67 Impact of Smoking Cessation and γ-Tocopherol to Restore Vascular Endothelial Function
Endothelial Dysfunction
Primary: Absolute Change in Brachial Artery Flow-mediated Dilation at Day 7 From Day 0 — 4.08; 2.77; 2.97; 2.66 % of preocclusion diameter
Phase 4 N=44 Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment
Healthy
Primary: Log Reactive Hyperaemic Index — 0.003; 0.095 LnRHI (Log Reactive hyperaemic index)
N/A N=21 Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease
Peripheral Artery Disease
Primary: Change in Vasodilator Capacity — 16.2; 16.4; 16.5; 14.2 ml/100ml tissue/min
Phase 4 N=28 Effect of Ezetimibe on Flow-mediated Brachial Artery Reactivity in Healthy Subjects
Endothelial Dysfunction
Primary: Percent Change in Flow Mediated Dilation — 12.3; 11.6; 10.9; 11.1 percent change
N/A N=25 Resveratrol and Vascular Function in CKD
Chronic Kidney Diseases · Endothelial Dysfunction
Primary: % Change of Brachial Artery Flow-mediated Dilation — 1.3; 0.91 %change
N/A N=17 Treating the Endothelium to Restore Insulin Sensitivity
Obesity · Insulin Resistance · Impaired Glucose Tolerance
Primary: Leg Blood Flow Response to Insulin — 0.24; 0.26; 0.353; 0.046 Liters/minute
N/A N=18 The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function
Endothelial Dysfunction
Primary: Endothelial Function — 3.31; 3.53 millimeters
Phase 4 N=21 Effect of Probiotic Supplementation on Endothelial Function
Coronary Artery Disease
Primary: Brachial Artery Flow Mediated Dilation — 1.2 percent change
N/A N=202 Dietary Intervention and Vascular Function
Cardiovascular Disease
Primary: Percent Change in Flow Mediated Dilatation (FMD) — -0.39; -0.07; -0.08 post-occlusion diameter change as % — p=0.238
Early Phase 1 N=11 Losartan for Improved Vascular Endothelial Function After Preeclampsia
Preeclampsia Postpartum
Primary: Cutaneous Conductance (%Maximum) Response to Acetylcholine — 89.4; 72.5 % of maximal cutaneous conductance
N/A N=23 Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Milk
Prediabetes
Primary: Vascular Endothelial Function — -307; -34.8; -36.8; -110 %*min
Phase 2 N=23 Role of Endothelin in Microvascular Dysfunction Following PCI for NSTEMI
Myocardial Reperfusion Injury
Primary: Average Peak Velocity (APV) Immediately Following Percutaneous Coronary Intervention (PCI) — 30; 19 cm/s — p=0.029
Phase 3 N=137 ENAC Blockade and Arterial Stiffness
Overweight and Obesity · Insulin Resistance
Primary: Carotid Femoral Pulse Wave Velocity — 7.25; 6.80; 7.12; 6.81 m/s
Phase 2 N=36 Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells
Diabetes Mellitus · Metabolic Syndrome X · Hypercholesterolemia
Primary: Change in Plasma Thiobarbituric Acid Reactive Substance (TBARS) Levels — 2.1; 2.5 nmol/mL
N/A N=25 Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function
Endothelial Dysfunction · Hyperhomocysteinemia · Hypertension Grade I, Subgroup "Borderline" (WHO)
Primary: Change in Endothelial Function Between the Visit at Start of Supplementation Phase and the Visit on the Final Day of the 4 Week Supplementation Phase (Delta "lnRHI")…
Phase 3 N=128 Vitamin D and Arterial Function in Patients With Chronic Kidney Disease
Arterial Dysfunction · Chronic Kidney Disease
Primary: Compare the Difference Between the Calcitriol and Cholecalciferol Groups in Conduit Artery Endothelium-dependent Dilation (EDD) in Response to Treatment. — -0.5; 0.3…
Phase 4 N=49 Effects of Linagliptin on Endothelial Function
Type 2 Diabetes · Coronary Artery Disease
Primary: Changes in Endothelial Function (FMD - Flow Mediated Dilatation) From Baseline to 12 Weeks — 0.4; -0.5 percentage of change in diameter (%)