Phase 3 N=25 Ketamine to Prevent PPD After Cesarean
Postpartum Depression
Primary: The Prevalence of Postpartum Depression in the Study Population, as Defined as EPDS Greater Than 10 Out of 30 — 4; 2; 5 Participants
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Phase 2 N=12 Ketamine for Depression and Suicide Risk
Depression · Suicide
Primary: MADRS Total Score at Baseline and Last Acute Phase Observation — 29.4; 29.4; 29.4; 15.9 units on a scale — p=<0.01
Phase 4 N=300 Ketamine for Acute Pain Management After Trauma
Trauma Injury · Pain · Opioid Use
Primary: Average Daily Opioid Use as Measured by the Morphine Milligram Equivalents (MME) Per Day — 32; 39 MME per day
Phase 4 N=82 Ketamine in the Treatment of Suicidal Depression
Major Depressive Disorder · Suicidal Ideation
Primary: Change in Scale for Suicidal Ideation — -3.66; -8.62 units on a scale
Phase 2 N=96 Ketamine for Reduction of Alcoholic Relapse
Primary Alcohol Use Disorder
Primary: Relapse Rates — 13; 15; 14; 18 Participants
Phase 1 N=25 Ketamine as an Adjunctive Therapy for Major Depression
Major Depressive Episode · Unipolar Depression · Bipolar Depression
Primary: The Hamilton Rating Scale for Depression-24 Item Version (HRSD-24) — 11.2; 16.6 score on a scale
Phase 4 N=110 Ketamine Versus Fentanyl for Surgical Abortions
Abortion in First Trimester · Pain, Procedural · Opioid Use
Primary: Satisfaction With Anesthesia Assessed by the ISAS — 2.4; 2.2 score on a scale
Phase 3 N=30 Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder (PTSD)
Primary: Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) — 22.5; 33.2 score on a scale
Phase 2 N=41 Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Stress Disorders, Post-Traumatic · PTSD · Depression
Primary: Impact of Event Scale - Revised (IES-R) — 25.76; 36.32 units on a scale
Phase 4 N=98 Sub-dissociative Dose Ketamine Dosing Study
Acute Pain
Primary: Change in Pain Score From Baseline to 30 Minutes Post Initiation of Drug Administration — 3.8; 3.5 score on a scale
Phase 2 N=16 Ketamine for Suicidality in Bipolar Depression
Bipolar Disorder · Major Depressive Episode · Suicidal Ideation
Primary: Change in Suicidal Ideation Measured With the Beck Scale for Suicidal Ideation — -12.4; -6.7 units on a scale
Phase 4 N=60 Ketamine For Acute Treatment of Pain in Emergency Department
Pain
Primary: Change From Baseline of Pain as Described by Numeric Rating Scale (NRS) [Minimum:0, Maximum 10] at 15 Minutes — 3.5; 6.0 units on a scale
Phase 2 N=8 Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
Depression
Primary: Evaluate the Effects of Ketamine on Depressive Symptomatology by Measuring Change in Score on the Montgomery-Asberg Depressive Rating Scale — 28.82; 25.20 units on a scale
Phase 4 N=45 Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery
Major Depressive Disorder · Surgery · Orthopedic Disorder
Primary: Montgomery-Asberg Depression Rating Scale (MADRS) Score — 17.0; 12.7; 16.4; 25.4 score on a scale — p=0.13
Early Phase 1 N=18 Ketamine Infusion for Social Anxiety Disorder
Social Anxiety Disorder
Primary: Visual Analogue Scale for Anxiety Symptoms (VAS-anxiety) — 12.1; 19.6 units on a scale
Phase 2 N=38 Ketamine in the Treatment of Depression
Major Depressive Disorder
Primary: Number of Responders 24-hours Post-ketamine Infusion — 3; 1; 3; 2 participants
Phase 4 N=24 Ketamine For Suicidal Ideation
Suicidal Ideation
Primary: Change in Beck Scale for Suicidal Ideation (BSSI) — 10.8; 14.0 units on a scale — p=0.32
N/A N=37 Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Major Depressive Disorder
Primary: Hamilton Depression Rating Scale - Suicidal Ideation (HDRS-SI) — 1.6; 1.6 units on a scale
Phase 4 N=31 Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
Unipolar Depression · Bipolar Depression
Primary: Hamilton Rating Scale for Depression (HRSD) Improvement — 7.82; 8.60 HRSD units
N/A N=48 Ketamine: Comparison of IV Push vs. IV Drip
Pain
Primary: Overall Rate of Feeling Unreality — 22; 13 Participants
Phase 2 N=21 Ketamine for the Treatment of Opioid Use Disorder and Depression
Depression · Opioid-use Disorder · Opioid Abuse
Primary: Percentage of Individuals Completing Informed Consent — 34 Participants
Phase 4 N=90 Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department
Pain
Primary: Numeric Rating Scale of Pain — 3.93; 4.07 Units on a scale
Phase 4 N=16 Ketamine for Depression: An MRI Study
Depression · Anxious Depression · Major Depressive Disorder
Primary: Change in Hamilton Depression Rating Scale (HDRS) From Baseline/Minute 0 to 4 Hours Post-infusion. — -9.625 score on a scale — p=<0.01
Phase 3 N=33 Ketamine for Treatment Resistant Late-Life Depression
Treatment Resistant Depressive Disorder
Primary: Percentage of Participants Demonstrating at Least a 50% Reduction on Montgomery-Asberg Depression Rating Scale Scores — 0; 2; 8; 6 Participants
Phase 4 N=135 Low Doses of Ketamine and Postoperative Quality of Recovery
Postoperative Pain · Postoperative Nausea and Vomiting
Primary: Quality of Postoperative Recovery Assessed by QoR-40 Questionnaire 24 Hours After Surgery — 187.8; 189.6; 186.8 units on a scale
Phase 4 N=62 Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department
Pain
Primary: Side Effects — 21; 25 Participants
N/A N=15 The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Mechanical Ventilation · Airway Patency · Respiratory Depression
Primary: Inspiratory Airflow — 0.36; 0.47; 0.44 L/s
Phase 3 N=16 EEG Studies of Ketamine General Anesthesia
Anesthesia
Primary: Average Pain Intensity Pre- and Post-Ketamine Induction — 7.9; 1.6; 4.1; 4.3 score on a scale
Phase 2 N=12 Ketamine and Prolonged Exposure in PTSD
Post-traumatic Stress Disorder
Primary: Change in Severity of Post-traumatic Stress Disorder (PTSD) Symptoms — 15.3 units on a scale
Phase 2 N=73 Optimization of IV Ketamine for Treatment Resistant Depression
Major Depressive Disorder (MDD) · Treatment Resistant Depression (TRD)
Primary: MADRS — 14.77; 22.72 units on a scale