N/A N=15 The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Mechanical Ventilation · Airway Patency · Respiratory Depression
Primary: Inspiratory Airflow — 0.36; 0.47; 0.44 L/s
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Early Phase 1 N=18 Ketamine Infusion for Social Anxiety Disorder
Social Anxiety Disorder
Primary: Visual Analogue Scale for Anxiety Symptoms (VAS-anxiety) — 12.1; 19.6 units on a scale
Phase 4 N=40 Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids
Psychoses, Substance-Induced
Primary: Brief Psychiatric Ratings Scale (BPRS) Positive Symptom Subscale Score — 0.00; 0.00; 1.40; 1.00 Scale of 0-6
Phase 2 N=12 Ketamine for Depression and Suicide Risk
Depression · Suicide
Primary: MADRS Total Score at Baseline and Last Acute Phase Observation — 29.4; 29.4; 29.4; 15.9 units on a scale — p=<0.01
Phase 2 N=52 The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction
Cognitive Disorders · Delirium · Acute Kidney Injury
Primary: Number of Patients With Postoperative Cognitive Dysfunction — 16; 10 Participants — p=0.23
N/A N=48 Ketamine: Comparison of IV Push vs. IV Drip
Pain
Primary: Overall Rate of Feeling Unreality — 22; 13 Participants
Phase 3 N=25 Ketamine to Prevent PPD After Cesarean
Postpartum Depression
Primary: The Prevalence of Postpartum Depression in the Study Population, as Defined as EPDS Greater Than 10 Out of 30 — 4; 2; 5 Participants
Phase 2 N=16 Ketamine and Nitroprusside for Depression
Depression
Primary: Montgomery-Asberg Depression Rating Scale — 13.4; 14.2 score on a scale
Phase 4 N=62 Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department
Pain
Primary: Side Effects — 21; 25 Participants
N/A N=54 Ketamine Infusion and Hypoventilation
Hypoventilation
Primary: Intraoperative Hypoventilation — 1.2; 65 % time
Phase 4 N=98 Sub-dissociative Dose Ketamine Dosing Study
Acute Pain
Primary: Change in Pain Score From Baseline to 30 Minutes Post Initiation of Drug Administration — 3.8; 3.5 score on a scale
Phase 2 N=8 Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
Depression
Primary: Evaluate the Effects of Ketamine on Depressive Symptomatology by Measuring Change in Score on the Montgomery-Asberg Depressive Rating Scale — 28.82; 25.20 units on a scale
Phase 2 N=67 Rapid Antidepressant Effects of Ketamine in Major Depression
Depression · Mood Disorders · Major Depresssion
Primary: MADRS Score - Baseline — 1.17; 1.48; 33.83; 31.82 units on a scale
Phase 4 N=110 Ketamine Versus Fentanyl for Surgical Abortions
Abortion in First Trimester · Pain, Procedural · Opioid Use
Primary: Satisfaction With Anesthesia Assessed by the ISAS — 2.4; 2.2 score on a scale
Phase 2 N=24 Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects
Healthy Volunteers
Primary: Change in The Profile of Mood States - Bipolar Version (POMS - Bi) Composed-Anxious Subscale — -6.8; -11.9 score on a scale
N/A N=20 Inhaled Nitrous Oxide for the Prevention of Emergence Reaction During Ketamine Administration in Adults, a Pilot Study
Emergence Reaction · Procedural Sedation
Primary: Emergence Reaction
Phase 2 N=73 Optimization of IV Ketamine for Treatment Resistant Depression
Major Depressive Disorder (MDD) · Treatment Resistant Depression (TRD)
Primary: MADRS — 14.77; 22.72 units on a scale
Phase 4 N=82 Ketamine in the Treatment of Suicidal Depression
Major Depressive Disorder · Suicidal Ideation
Primary: Change in Scale for Suicidal Ideation — -3.66; -8.62 units on a scale
Phase 4 N=60 Ketamine For Acute Treatment of Pain in Emergency Department
Pain
Primary: Change From Baseline of Pain as Described by Numeric Rating Scale (NRS) [Minimum:0, Maximum 10] at 15 Minutes — 3.5; 6.0 units on a scale
Phase 1 N=25 Ketamine as an Adjunctive Therapy for Major Depression
Major Depressive Episode · Unipolar Depression · Bipolar Depression
Primary: The Hamilton Rating Scale for Depression-24 Item Version (HRSD-24) — 11.2; 16.6 score on a scale
Phase 4 N=45 A Comparison of Intra-op Ketamine vs Placebo in Patients Having Spinal Fusion
Postoperative Pain
Primary: Scores on Questionnaires — 95; 101 points — p=0.86
Early Phase 1 N=6 Ketamine for Depression Relapse Prevention Following ECT
Depression
Primary: Completion Rate for Randomised Treatment — 0; 0 Participants
Phase 4 N=55 Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects
Pain, Acute · Dissociation
Primary: Side Effect Rating Scale for Dissociative Anesthetics (SERSDA) Composite Score — 1.88; 0.42; 1.17; 3.67 Scores on a Scale — p=<0.001
Phase 4 N=300 Ketamine for Acute Pain Management After Trauma
Trauma Injury · Pain · Opioid Use
Primary: Average Daily Opioid Use as Measured by the Morphine Milligram Equivalents (MME) Per Day — 32; 39 MME per day
Phase 4 N=24 Ketamine For Suicidal Ideation
Suicidal Ideation
Primary: Change in Beck Scale for Suicidal Ideation (BSSI) — 10.8; 14.0 units on a scale — p=0.32
Phase 2 N=41 Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Stress Disorders, Post-Traumatic · PTSD · Depression
Primary: Impact of Event Scale - Revised (IES-R) — 25.76; 36.32 units on a scale
Phase 2 N=38 Ketamine in the Treatment of Depression
Major Depressive Disorder
Primary: Number of Responders 24-hours Post-ketamine Infusion — 3; 1; 3; 2 participants
N/A N=37 Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Major Depressive Disorder
Primary: Hamilton Depression Rating Scale - Suicidal Ideation (HDRS-SI) — 1.6; 1.6 units on a scale
Phase 3 N=183 Ketamine Versus Co-administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department
Procedural Sedation and Analgesia
Primary: Frequency of Adverse Events — 12; 15; 1; 0 participants
Phase 2 N=34 Ketamine Plus Lithium in Treatment-Resistant Depression
Depression
Primary: MADRS-S Score — 22.56; 23 units on a scale