Clinical Trial Search

Primary: Percentage Change From Baseline in the Eczema Area and Severity Index (EASI) Score at Week 12. — -10.98; -25.99; -31.57 percent change — p=0.1308

Primary: Proportion of Patients Achieving an Investigator's Global Assessment (IGA) of 0 (Clear) or 1 (Almost Clear) and a Decrease of at Least 2 Points in IGA at Week 8. — 0.12…

Primary: Change From Baseline in Eczema Area and Severity Index (EASI) Compared to Placebo at Week 16 — -3.8; -6.1 units on a scale

Primary: Proportion of Subjects Who Achieve ≥75% Overall Improvement in Eczema Area and Severity Index (EASI) Score From Baseline to Week 16. — 9.8; 18.1; 12.5; 15.1 percentage…

Primary: Fold-Change in Epidermal Thickness of Lesional Skin — 1.15; 1.5; 1.18; -1 fold-change

Primary: Percentage of Participants Who Had at Least a 2-grade Reduction From Baseline at Week 6 in the Investigator Global Assessment (IGA) Scale and Had an IGA at Week 6 That…

Primary: Change in Eczema Area Severity Index (EASI) Score From Baseline (Week 1) to Week 16. — 26.4 Scores on a scale.

Primary: Percentage of Participants Achieving ≥ 90% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 90) at Week 24 — 74.6; 48.1; 68.5; 29.3 percentage of…

Primary: Number of Allergen-induced Eosinophils in the Skin — 11.95; 71.15 cells/mm2

Primary: Percentage of Participants With an Investigator's Global Assessment (IGA) Success (IGA of 0 or 1 and a More Than Equal to [>=] 2-point Reduction): Intent-To-Treat (ITT)…

Primary: Change From Baseline in the m-EASI (Eczema Area Severity Index) Score. — 5.04; 4.77 units of a 0-12 scale — p=<0.05

Primary: Percentage of Participants With Investigator's Global Assessment (IGA) Success at Week 16: Intent-To-Treat (ITT) Population — 37.7; 26.0 percentage of participants…

Primary: Percentage of Participants Who Had at Least a 2-grade Reduction From Baseline at Week 6 in the Investigator Global Assessment (IGA) Scale and Had an IGA at Week 6 That…

Primary: Percentage of Participants Achieving a ≥ 90% Reduction From Baseline in Eczema Area and Severity Index Score (EASI 90) and Worst Pruritus Numerical Rating Scale of 0 or…

Primary: Percent Change From Baseline in Eczema Area and Severity Index (EASI) Score at Week 12- Last Observation Carried Forward (LOCF) — -23.3; -74.0 percent change

Primary: The Percentage of Subjects Achieving Investigator's Global Assessment (IGA) Response Which Improvement ≥ 2 From Baseline. — 9; 19; 2 Participants

Primary: Subjects With Investigator's Global Assessment (IGA) Score of 0 (Clear) or 1 (Almost Clear) at Week 16. — 131; 22 Participants — p=<0.001

Primary: Percent Change From Baseline in Eczema Area and Severity Index (EASI) at Week 24 — -58.4; -72.2; -73.4; -69.2 percentage change — p=0.051

Primary: Proportion of Patients Achieving at Least 75% Reduction in Eczema Area and Severity Index [EASI] at Week 26 — 94.1 percentage of patients achieved EASI75

Primary: The Number of Patients in Each Treatment Group That Have Clinical Success — 21; 27 Participants — p=0.3353

Primary: Percentage of Participants With Investigator's Global Assessment (IGA) Score of "0" or "1" and Reduction From Baseline of ≥2 Points at Week 16 — 8.5; 36.1; 36.4…

Primary: Percentage of Participants With Investigator's Global Assessment (IGA) Score of "0" or "1" and Reduction From Baseline of ≥2 Points at Week 16 — 10.3; 37.9; 37.2…

Primary: Double-blind Treatment Period: Percent Change in Eczema Area and Severity Index (EASI) Score — -58.68; -57.18; -48.41 Percent change — p==0.1198

Primary: Number of Patients With Treatment Emergent Adverse Events (TEAEs) — 3; 6 Participants

Primary: Percentage of Participants With Investigator's Global Assessment (IGA) Score of "0" or "1" and Reduction From Baseline of ≥2 Points at Week 16 — 12.4; 38.7; 39.2…

Primary: Main Study: Percentage of Participants Achieving at Least a 75% Reduction in Eczema Area and Severity Index Score (EASI 75) From Baseline at Week 16 — 16.3; 69.6; 79.7…

Primary: Percent Change in Eczema Area and Severity Index Score (EASI) From Baseline to Week 16 — -75.5; -70.5; -67.4; -64.9 Percent change — p=<0.0001

Primary: Change From Baseline in the Numerical Rating Score (NRS) for Pruritus (Worst Itch) — 7.3; 7.26; 4.27; 4.6 score on a scale — p== 0.249

Primary: Percent Change From Baseline in Eczema Area and Severity Index (EASI) Score at Week 4 — -74.45; -41.43 percent change — p=<0.001

Primary: Percent Change From Baseline to Week 16 in Eczema Area and Severity Index (EASI) Score — -48.33; -49.72; -61.07; -57.35 percentage of score change — p=< 0.001