Clinical Trial Search

Primary: 3 Scores on the Addiction Research Center Inventory (ARCI) — 7.6; 5.4; 5.2; 3.3 scores on a scale

Primary: Retention Without Relapse to Heroin Addiction (Measured at Month 6) — 54; 16; 11 Participants

Primary: Proportion of Patients Abstinent From Marijuana During Weeks 7 and 8 of the Trial — 14; 12 participants

Primary: Area Under the Curve (AUC) in COWS Total Score on Days 1 to 5 Inclusive — 4.2; 3.4 Average COWS score * hours

Primary: Analgesia — 36.3; 71.8 units on a VAS scale — p=0.097

Primary: Retention in Treatment — 7; 5; 6 participants — p=0.32

Primary: Opiate Use Measured by Urine Toxicology Results — 9; 10 Percent of total urine samples

Primary: Number of Participants Retained in Treatment — 13; 13 participants — p=0.77

Primary: Opiate Withdrawal Measured by the Subjective Opiate Withdrawal Scale (SOWS) . — 11.16; 13.36 units on a scale

Primary: Successful Naltrexone Initiation — 11 Participants

Primary: Proportion of Patients Successfully Inducted to Receive Naltrexone Injection — 12; 7 Participants

Primary: Number of Participants Retained in Study — 18 participants

Primary: Change in Marijuana Use — -1.7 days

Primary: The Number of Participants Attaining Successful Opioid Use Outcome by Counseling Condition at End of Phase 1 — 19; 24 participants

Primary: Time to Relapse (Intent to Treat Population) — 8.4; 14.4 weeks

Primary: Days of Opioid Use — 6.8 days

Primary: Implementation (Considered the Primary Outcome) — 2; 53 Participants — p=<0.001

Primary: PARS Help-Seeking Scale — 0.57; 0.53 units on a scale

Primary: Abuse Liability Proxy — 0.197; 0.483; 0.159; 7.678 units on a scale (points 0-100) — p=<.05

Primary: Change in Dopamine Levels at Baseline and After Drug of Dependence Administration as Confirmed by PET Images. — 0.0388; 0.033; 0.0285; 0.0368 mm^3

Primary: Odds of Morphine Equivalent Daily Dose (MEDD) of Opioid Prescription >=50 mg — 0.209; 0.417; 0.185; 0.364 odds of prescription high dose — p=0.956

Primary: Finnegan Neonatal Abstinence Scoring System — 7.5; 8.5; 6.6; 5.7 scores on a scale

Primary: TB Treatment Completion Rates in Prison — 114; 127 Participants — p=0.08

Primary: Detoxification Phase: Changes in Percent of Illicit Opioid-positive Urine Samples Over Time — 35.0; 41.6 percentage of urine positive samples — p=0.77

Primary: Percentage of Positive Toxicology Swabs for Illicit Substances — 81.3; 79.1; 86.2; 82.3 percentage of positive toxicology screen

Primary: Percent of Weekly Urine Samples Negative for Opiates — 64.5; 81.3; 71.1; 66.7 percentage of negative urine samples — p=0.48

Primary: Percentage of Urine Samples Positive for Naltrexone — 21; 72 Percentage of Urine Samples — p=<0.01

Primary: Change From Week 0 in Cannabis Use Using Urinary CN-THCCOOH Levels at Week 8 — -334.21; -359.95 ng/mg

Primary: Number of Participants With Drug Use at 3 Months — 49; 48 participants

Primary: Change in Average Waiting Time From First Contact to Treatment — .253; 4.610; 4.723; 3.520 Change in days