N/A N=47 Nasal Septal Flap for Donor Site Reconstruction
Nasal Septum Perforation
Primary: Mean Change in Post-operative Remucosalization at the Donor Site — 47.8; 37.8; 49.7; 43.5 percentage of remucosalization
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=42 The Effectiveness of Nasal Corticosteroids Versus Placebo in Nasal Obstruction in Patients With Nasal Septal Deviation
Nasal Obstruction
Primary: Nasal Obstruction as Measured by Nasal Obstruction Symptom Evaluation (NOSE) Scores Following Therapy With Treatment (Triamcinolone Acetonide) and Placebo (Ayr Saline…
N/A N=16 Comparison of a Septal Stapler to Suture Closure in Nasal Septoplasty
Nasal Obstruction
Primary: Operative Time — 35; 423 seconds
N/A N=50 A Clinical Evaluation of the Sinexus Intranasal Splint Following Functional Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis
Chronic Sinusitis
Primary: Device Success Rate — 14; 76; 10 ethmoid sinuses
N/A N=113 Spirox Latera™ Implant Support of Lateral Nasal Wall Cartilage (LATERAL-OR) Study
Nasal Obstruction
Primary: The Primary Efficacy Endpoint is the Percent of Treatment Responders — 101 Participants
Phase 3 N=18 Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis
Chronic Sinusitis · Polyposis
Primary: Olfaction — 20.2; 19.8 units on a scale
N/A N=30 Safety and Efficacy Study of Polydioxanone (PDS) Plates in Rhinoplasty
Rhinoplasty
Primary: Live Assessment of Satisfaction With the Grafts — 2; 4 units on a scale
N/A N=20 Treatment Outcome Using Vivaer Stylus to Treat Nasal Airway Obstruction
Nasal Obstruction
Primary: Change in NOSE Score — -44.5 units on a scale
N/A N=50 Clinical Evaluation of the Steroid-Eluting Sinexus Intranasal Splint When Used Following Functional Endoscopic Sinus Surgery (FESS) in Patients With Chronic Sinusitis
Chronic Sinusitis
Primary: Safety as Determined by the Frequency of Serious Adverse Local Tissue Response (SALT) — 6 Number of Sinuses
Phase 4 N=65 Nasal Decolonization for Orthopedic Trauma Patients
Surgical Site Infection
Primary: Number of Participants With Staphylococcus Aureus Nasal Colonization — 12 Participants
N/A N=33 InFlux System for Nasal Breathing Improvement
Nasal Airway Obstruction
Primary: Incidence of Unanticipated Serious Adverse Device Effects — 0 events
N/A N=30 Evaluation of an Absorbable Implant for the Treatment of Nasal Valve Collapse
Nasal Valve Collapse
Primary: Implant-related Adverse Events — 5 participants
N/A N=94 Barrow Nasal Inventory Survey
Pituitary Tumors
Primary: Change in Mean Survey Response From Baseline to 90 Days Post Surgery — 17.3; 13.5 units on a scale — p=0.001
N/A N=50 Treatment of Nasal Airway Obstruction Using the Aerin Medical Device
Nasal Obstruction
Primary: Improvement in NOSE Score — 54.8 units on a scale — p=<0.0001
N/A N=40 Safety and Performance of ENTACT Septal Staple System for Septoplasty
Septoplasty
Primary: Percentage of Participants With Clinical Success of the ENTACT Septal Staple System by Examining the Participant's Nasal Cavity at the 21 Day Follow-up Visit — 94.7…
N/A N=70 The Vivaer Procedure for Treatment of the Septal Swell Bodies (SWELL)
Nasal Obstruction
Primary: Nasal Obstruction Symptom Evaluation (NOSE) Scale Mean Change — -45.3 score on a scale
Phase 3 N=407 Effect of Mepolizumab in Severe Bilateral Nasal Polyps
Nasal Polyps
Primary: Change From Baseline in Total Endoscopic Nasal Polyps Score at Week 52 — 0.0; -1.0 Scores on a scale — p=<0.001
Phase 2 N=105 Mepolizumab in Nasal Polyposis
Nasal Polyps
Primary: Number of Participants With a Reduced Need for Surgery at Week 25 — 16; 5; 33; 46 Participants — p=0.003
N/A N=39 Quality of Life Impact of Nasal Airway Treatment With Aerin Medical Device
Nasal Obstruction
Primary: Change From Baseline NOSE Score — 53.3; 48.1; 53.5 units on a scale — p=<0.0001
N/A N=36 A New Treatment for Mechanical Nasal Obstruction
Nasal Obstruction
Primary: Change in Peak Nasal Inspiratory Flow (PNIF) — 28; 24; 13; 27 liters per minute
N/A N=32 Comparison of Nasal Steroids After FESS in CRSwNP
Sinusitis · Nasal Polyps
Primary: SNOT-22 Scores — 31.5; 10.29; 15.88 units on a scale
Phase 4 N=50 Septorhinoplasty Post-operative Pain Control With SPG Nerve Block
Deviated Nasal Septum
Primary: Post Operative Pain Scores — 3.9; 3.8; 2.7; 2.9 pain score on a scale of 0-10
N/A N=25 Study of the ENTact Septal Staple System for Tissue Approximation During Septoplasty
Nasal Septum
Primary: Coaptation (Tissue Approximation) — 23 participants
N/A N=50 Posterior Nasal Nerve (PNN) Rhinitis Study
Chronic Rhinitis
Primary: Change in Reflective Total Nasal Symptom Score (rTNSS) — -5.1 units on a scale — p=<0.0001
N/A N=12 Impact of Symbiofilm On Nasal Microbiota
Rhinosinusitis Chronic · Microbiome
Primary: Comparaison of Alpha-diversity of Sino-nasal Microbiota Before and After Treatment (Visit 1 and Visit 2) — 2.041; 2.114 Shannon Index — p=0.908
Phase 4 N=41 NasoNeb Delivery of an Intranasal Steroid
Perennial Allergic Rhinitis
Primary: Change in Nasal Peak Inspiratory Flow (NPIF) — 36.41; 18.71 liters/min
Phase 3 N=323 Study Evaluating the Efficacy and Safety of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi Directional Device in Subjects With Bilateral Nasal Polyposis Followed by an 8-Week Open-Label Extension Phase to Assess Safety
Bilateral Nasal Polyposis
Primary: Change in 7-day Average Instantaneous Morning Diary Congestion/Obstruction Symptoms — -0.26; -0.53; -0.56; -0.67 units on a scale
N/A N=20 Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease
Nasal Polyps · Gastroesophageal Reflux
Primary: Presence of Reflux in Patients With Polyposis — 15 participants
Phase 4 N=34 Nasonex (Mometasone Furoate Nasal Spray) in Adenoids Hypertrophy in Children (P04367)
Adenoids
Primary: Severity of Nasal Obstruction Symptoms at Baseline and Week 12 as Measured by the Total Clinical Score — 3.89; 1.26 Score on a scale
Phase 3 N=408 Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis
Chronic Rhinosinusitis With Nasal Polyps
Primary: Change From Baseline in Total Nasal Polyp Score at Week 52 — -2.458; -0.380 Score — p=<.0001