Clinical Trial Search

Primary: Percentage of NLFs With Treatment Success at Month 6 — 66.0; 72.8 Percentage of successfully treated NFLs

Primary: Mean Change From Baseline in Wrinkle Severity Rating Scale (WSRS) at 6 Months — -0.03; 0.03 units on a scale

Primary: Responder Rate in Reduction of Nasolabial Folds — 34; 39; 73 Participants

Primary: Percentage of Participants With a ≥ 1 Grade Improvement on the Assessment of Aesthetic Improvement Scale (AAIS) as Assessed by the Central Evaluating Physician at Day…

Primary: Number of Participants With Adverse Events — 23; 59; 1; 2 Participants

Primary: Superiority Analysis of The Percentage of Responders Measured by the Investigator's Live Assessment (ILA) at Maximum Frown at Cycle 1, Day 29 (DB Period). — 95.2; 0.9…

Primary: Mean Change From Baseline in Overall Lifting and Tightening of Submental (Under the Chin) and Neck Tissue Area at Day 90 Post-treatment — -14.4; -7.9; -22.3 square…

Primary: Volume Change From Baseline in the Nose Area — -0.005; 2.032 cubic centimeters (cc) — p=<0.0001

Primary: Percentage of Participants (Responders) With At Least 1-Point Improvement From Baseline on the GCRS, as Assessed by the Blinded Evaluator at Month 6 ([Baseline…

Primary: NLF-SRS Grade of Nasolabial Folds Change — -1.50 score on a scale

Primary: Percentage of Subjects With a ≥ 1-Grade Improvement From Day 1 in the Investigator Assessed Facial Wrinkle Scale of Glabellar Rhytides at Maximum Contraction — 97.1…

Primary: Percentage of Participants Assessed as At Least 1-point Improvement From Baseline on Medicis Lip Fullness Scale (MLFS) — 94.7; 94.7 percentage of participants

Primary: Number Participants With Hypertropic Scarring, Keloid Formation, Hyper- or Hypopigmentation in Patients With Fitzpatrick Skin Types IV, V, and VI Receiving Nasolabial…

Primary: Nasal Tip Projection — 0.601 ratio

Primary: Mean Change From Baseline in Nasolabial Fold Severity Using the 5-Point Nasolabial Fold Severity Scale (NLFSS) — 2.6; 2.6; 1.4; 1.3 Scores on a Scale

Primary: Responder Status Based on Independent Evaluating Investigator Live Assessment at Week 24 - Full Analysis Dataset — 222; 221 Participants — p=<0.0001

Primary: Percentage of Responders, Defined by at Least 1-point Improvement From Baseline on the WSRS. — 72.9; 72.8 percentage of subjects

Primary: Change From Baseline to Week 24 on the Wrinkle Severity Rating Scale (WSRS) — 3.4; 3.4; 2.4; 2.4 score on a scale

Primary: Response Rate in Treatment of Nasolabial Fold (NLF) Based on a Scale — 63.2; 68.4 percentage of participants

Primary: Change in Wrinkle Severity Rating Scale — -0.94; -1.07 units on scale

Primary: Percentage of Participants in Each Response Category for Overall Participant Satisfaction at Visit 6, Assessed by the Subject Satisfaction Questionnaire — 71.1; 28.9; 0…

Primary: Pain Score Using a 10-cm Visual Analog Scale (VAS) for Pain (0 = no Pain, 10 = Very Severe Pain) — 2.32; 6.73 units on a scale — p=<0.0001

Primary: Procedural Pain Score — 2.0; 4.1 units on a scale

Primary: Average of Wrinkle Severity Rating Scale (WSRS) Score Evaluated by the Evaluating Investigator at Week 26 (Visit 7) After the Final Treatment With the Investigational…

Primary: Change in Wrinkle Assessment Scale (WAS) Score — -1.3; -1.3; -1.2; -1.3 units on a scale

Primary: Inter-rater Reliability of Assessment of Facial Lines Using the 4-Point Facial Wrinkle Scale (FWS-A) — 0.653; 0.637; 0.647; 0.654 Kappa statistics

Primary: Change From Baseline in the Nasolabial Folds Severity Score on the Wrinkle Severity Rating Scale (WSRS) 6 Months After Treatment — -0.3; -0.2; -0.1 score on a scale

Primary: Percentage of Subjects Achieving None or Mild on the Investigator's Assessment of the Severity of Crow's Feet Lines (CFL) at Maximum Smile Using the Facial Wrinkle…

Primary: Pharmacokinetics Measure - Drug Concentration in the Blood (ng/mL) — 487.7; 473.3 concentration (ng/ml)

Primary: First Impressions — 46.756; 27.769; 46.391; 34.404 score on a scale