Phase 3 N=124 Treatment of Obsessive Compulsive Disorder in Children
Obsessive-Compulsive Disorder
Primary: Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) — 0.69; 0.34; 0.30 Proportion of Participants with RESPONSE
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=11 N-acetylcysteine (NAC) for Pediatric Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder
Primary: OCD Severity at 12 Weeks — 21.4; 21.3 points on a scale
Phase 2 N=30 D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
Obsessive-compulsive Disorder
Primary: Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS; Scahill et al., 1997). — 26; 24.1; 17.9; 15.6 units on a scale — p=<0.05
N/A N=55 Overlapping Neural Circuits in Pediatric OCD
Obsessive Compulsive Disorder
Primary: Brain Activation Associated With the Resolution of Cognitive Conflict — .7; .59 Arbitrary units — p=0.0585
Phase 2 N=31 Videophone Administered Cognitive-Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder
Obsessive Compulsive Disorder
Primary: Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS; Scahill et al., 1997). The CY-BOCS is a 10-item Semi-structured Measure of Obsession and Compulsion Severity…
Phase 3 N=142 D-cycloserine Augmentation of Cognitive Behavioral Therapy (CBT) for Pediatric Obsessive-compulsive Disorder (OCD)
Obsessive-compulsive Disorder
Primary: Children's Yale-Brown Obsessive-Compulsive Scale. — 13.53; 13.98 units on a scale
N/A N=142 2/2 D-Cycloserine Augmentation of CBT for Pediatric OCD
Obsessive-Compulsive Disorder
Primary: Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) — -10.35; -9.40 Change in score from randomization
Phase 2 N=60 Riluzole to Treat Child and Adolescent Obsessive-Compulsive Disorder With or Without Autism Spectrum Disorders
Obsessive-Compulsive Disorder · Autism Spectrum Disorder · Autism
Primary: Much/Very Much Improved on Clinical Global Impressions - Improvement Score (CGI-I) — 3; 4 participants — p=0.959
Phase 2 N=5 Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)
Obsessive-Compulsive Disorder
Primary: Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) — 29.00; 26.20 score on a scale — p=.20
Phase 4 N=56 Effectiveness of Sertraline and Cognitive Behavioral Therapy in Treating Pediatric Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder
Primary: Clinical Global Impression - Severity of Activation (CGI-SA) — .50; 2.00; 2.00 units on a scale — p=.2106
N/A N=136 Parent-based Treatment for Youth With Anxiety and Obsessive-compulsive Disorder
Obsessive-Compulsive Disorder in Children · Social Anxiety Disorder of Childhood · Obsessive-Compulsive Disorder in Adolescence
Primary: Pediatric Anxiety Rating Scale — 10.86; 10.96 score on a scale
Phase 2 N=31 Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD
Obsessive Compulsive Disorder
Primary: Yale-Brown Obsessive Compulsive Scale, Child Version (CYBOCS) — 28.20; 29.0; 26.67; 27.11 units on a scale
Phase 3 N=38 A Phase 3 Study of Fluvoxamine (SME3110) in Pediatric/Adolescent Patients With Obsessive Compulsive Disorder
Obsessive Compulsive Disorder
Primary: Mean Change From Baseline in the Japanese Children's Yale-Brown Obsessive Compulsive Scale 10-item Total Score at the End of Treatment in the First Phase — -10.5; -6.6…
Phase 3 N=45 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders
Autism · Asperger's Syndrome · Generalized Anxiety Disorder
Primary: Pediatric Anxiety Rating Scale (Measures the Severity of Anxiety Symptoms) — 16.33; 17.62; 11.58; 16.05 units on a scale
Phase 4 N=62 Effects of Ondansetron in Obsessive-compulsive and Tic Disorders
Obsessive-Compulsive Disorder · Tic Disorders · Tourette Syndrome
Primary: Change in Brain Activation - Insula Cortex — -0.071; -0.0094 Parameter estimate of BOLD Signal Change
N/A N=120 Digital Health Interventions for Obsessive Compulsive Disorder (OCD)
Obsessive-Compulsive Disorder
Primary: Difference in OCD Symptom Severity at the End of Week 12 — 25.12; 23.77; 18.68; 20.49 score on a scale — p=0.0871
Phase 3 N=48 Intravenous Immunoglobulin for PANDAS
Obsessive-Compulsive Disorder · Children · Anxiety Disorder
Primary: Children's Yale-Brown Obsessive Compulsive Scale Total Score — 20.59; 25.67 units on a scale — p=0.44
N/A N=16 D-Cycloserine Augmentation to CBT With Exposure and Response Prevention in Adults and Adolescents With OCD
Obsessive Compulsive Disorder
Primary: Child Yale-Brown Obsessive Compulsive Scale (CY-BOCS) for Adolescents — 26.56; 27.25; 22.44; 19.8 units on a scale
Phase 2 N=15 Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD)
Obsessive-Compulsive Disorder
Primary: Number of Patients Who Met and Exceeded Response Criteria of Yale-Brown Obsessive-Compulsive Scale. — 0; 5 participants
Phase 2 N=10 Ketamine Infusion for Obsessive-Compulsive Disorder
Obsessive-compulsive Disorder
Primary: OCD Severity — -2.7 units on a scale
N/A N=100 Risperidone or Cognitive-Behavioral Therapy for Improving Medication Treatment for Obsessive-compulsive Disorder
Obsessive-Compulsive Disorder
Primary: Score on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) — 26.1; 27.2; 25.9; 22.6 units on a scale
Phase 4 N=20 Duloxetine for the Treatment of Obsessive Compulsive Disorder (OCD)
Obsessive Compulsive Disorder
Primary: Y-BOCS Scores at 1st and Last Visit — 27.45; 20.45 units on a scale
Phase 4 N=43 Fluoxetine in Pediatric Body Dysmorphic Disorder
Body Dysmorphic Disorder
Primary: Change in Total Score on the BDD-Y-BOCS Scale — -12.27; -9.53 units on a scale
N/A N=64 Early Intervention for Children at Risk for Anxiety
Anxiety Disorder
Primary: Number of Responders Based on Clinician Global Impression-Anxiety Improvement — 20; 9 Participants — p=<.05
N/A N=13 Tx for Child Sexual Behavior Problems
Sexual Behavior
Primary: Child Sexual Behavior on the Child Sexual Behavior Inventory (CSBI) — 28.8; 18.1 Scores on a scale
Phase 3 N=20 Tolcapone in Obsessive Compulsive Disorder
Obsessive-Compulsive Disorder
Primary: Yale Brown Obsessive Compulsive Scale (Y-BOCS) — -4.24; -1.10 mean change in YBOCS score
Phase 2 N=47 Antibiotic Treatment Trial for the PANDAS/PANS Phenotype
PANS · PANDAS · Obsessive Compulsive Disorder (OCD)
Primary: Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) — 29.49; 28.43; 20.53; 23.45 units on a scale
N/A N=34 Stepped Care for Treating Obsessive-Compulsive Disorder
Obsessive-compulsive Disorder
Primary: Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) Total Score — 26.00; 24.47; 14.25; 15.16 units on a scale
N/A N=7 TMS for Improving Response Inhibition in Adolescents With OCD
Obsessive-Compulsive Disorder
Primary: Change in Response Time on Stop Trials of the Stop Signal Task — -26.2; -31.7 milliseconds
N/A N=10 Transcranial Magnetic Stimulation for Children With Tourette's Syndrome
Tourette Syndrome
Primary: Yale Global Tic Severity Scale — 64.40; 26.40 units on a scale