Clinical Trial Search

Primary: Inflammation — -11.47; -37.45; -32.66 percentage of change in crp at week 24

Primary: Change in Apnea-hypopnea Index (AHI) Outcome Measure in Response to Pioglitazone or Placebo — 35.8; 34.4 AHI events/hour

Primary: Apnea-hypopnea Index (AHI) at One Year — 35.3; 39.6 events per hour

Primary: Number of Participants With a Negative Obstructive Sleep Apnea (OSA) Home Sleep Test Result — 61 Participants

Primary: Ventilation (Aim 1) — 1.19; 1.14; 1.35; 1.16 fraction of baseline — p=0.001

Primary: Fat Mass (% of Total Body Mass) — 40.0; 37.7; 38.7; 38.6 percentage of total body mass

Primary: Change of Daytime Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) Pre-treatment and Post-treatment — -8; -3; -4; -3 mm Hg — p=<0.05

Primary: Positive Berlin Questionnaire Indicative of Sleep Disordered Breathing — 1343; 96 participants — p=0.001

Primary: Model Prediction of Absence/Presence of OSA: Ventilation That Causes an Arousal From Sleep (Varousal) — 5.7; 5.2 L/min — p=0.05

Primary: Flow Mediated Dilation — 5.7; 9.5; 7.3 percentage change of vessel diamter — p=0.02

Primary: Severity of Obstructive Sleep Apnea — -18.3; 7.0 events/hour

Primary: Physical Activity, Steps Walked — 5892; 6071; 6284; 6684 steps walked

Primary: Change Over 6 Months in Epworth Sleepiness Scale Score — -0.23; -1.05; 0.43; -2.62 units on a scale

Primary: Change From Baseline in Area Under the Curve (AUC) Glucose at Week 2 — -794.2; 482.7 (mg/dL)*min — p=0.03

Primary: Apnea Hypopnea Index (AHI, Events/Hour of Sleep) — 33; 20.4 events/hour of sleep — p=0.47

Primary: Change From Baseline in Mean Arterial Blood Pressure — -4.21; -0.95 mm Hg

Primary: Effective Apnea Hypopnea Index — 29.5; 20.0 Events per hour

Primary: Change in Continuous Glucose Monitoring System Standard Deviation — 0.8; 1.1 mg/dL

Primary: Apnea Hypopnea Index (AHI, Events/Hour of Sleep) — 21.6; 37.9 events/hour of sleep — p=0.56

Primary: CPAP Adherence — 2.8; 3.9 hours per night — p=0.001

Primary: QT Interval (Corrected) Baseline Visit — 453.4 square root of seconds — p=0.73

Primary: Left Ventricular Ejection Fraction Improvement — 4.5; -.3 percent change

Primary: Absolute Change in Brachial Artery Flow-mediated Dilation (FMD). — 2.26; 1.59 percentage of brachial artery diameter

Primary: Apnea Hypopnea Index - Crossover — 34.9; 39.6 units on a scale

Primary: Concentration of Plasma Free Fatty Acids (FFA, mmol/L) — 0.47; 0.51 mmol/L

Primary: Change in the Apnea/Hypopnea Index (AHI) Between Baseline and Week 28/Early Term. — -16.6; -31.46 events/hour — p=0.0084

Primary: Ability to Use the Devices at Home — 15 Participants

Primary: Objective Sleep Parameters

Primary: Respiratory Event Index (REI) at T2 — 12.8; 21.1; 9.3; 13.1 number of events per hour — p=0.152

Primary: Change From Baseline in 24-hour Blood Pressure at Months 6 and 12 by Pooled Arms — 1.82; 1.06; 0.59; -0.73 mmHg