N/A N=20 Acute Comfort of Lubricant Eye Drop FID 111421
Dry Eye
Primary: Drop Comfort Upon Instillation — 1.7; 1.3 Units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=60 Dailies Total 1 Sphere Contact Lenses
Dry Eye · Contact Lens Complication
Primary: Visual Analog Scale (VAS) Contact Lenses Comfort Scores — 44 Score on a scale — p=<0.001
N/A N=72 Ocular Comfort and the "Aging" Lens (ERBIUM)
Refractive Error
Primary: Phase 3: Ocular Comfort, Lens Age 1 Day, Hour 1 — 76; 88 Units on a scale
N/A N=20 Acute Comfort of Lubricant Eye Drops FID 112903
Dry Eye
Primary: Drop Comfort Upon Instillation — 1.1; 1.4 Units on a scale
N/A N=40 Acute Comfort and Blur of Systane and Optive
Dry Eye
Primary: Visual Blur — 27.7; 33.55 Units on a scale
N/A N=20 An Investigation of the Impact of Localized Topical Anesthesia of the Ocular Surface on End-of-day Contact Lens Discomfort
Visual Acuity
Primary: Subjective Comfort Scores — 79.25; 70.93; 61.00; 61.94 Units on a Scale
N/A N=20 Acute Comfort and Blurring Profile Evaluation of Marketed Lubricant Eye Drops
Dry Eye
Primary: Drop Comfort — 0.7; 1.05; 1.84; 1.1 units on a scale
N/A N=30 Neurolens and Contact Lens Discomfort
Contact Lens Discomfort
Primary: Change in Contact Lens Discomfort — -4.94; -8.67 Scores on a scale
N/A N=45 The Impact of Soft Contact Lens Attributes on Symptoms Associated With Digital Eye Strain in Symptomatic Soft Contact Lens Wearers
Asthenopia · Myopia
Primary: Subject Reported Eye Fatigue — 18; 21; 21; 17 units on a scale — p=0.18
N/A N=20 Ocular Comfort and OCT Observation of Post Lens Clearance and Ocular Tissue Compression
Ocular Comfort
Primary: Final Comfort — 87.6; 87.9 Units on a scale
N/A N=28 Clinical Investigation on the Use of Ophthalmic Solution Based on Sodium Hyaluronate in Treatment of Eye Discomfort
Ocular Dryness
Primary: Tear Film Break-up Time With Fluorescein (TFBUT) — 5.00; 13.46 Second
Phase 4 N=46 Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort
Contact Lens Discomfort · Dry Eye
Primary: Contact Lens Symptoms — 20.41; 18.92; 12.86; 17.92 Score on a Scale
N/A N=35 Evaluation of Ocular Comfort With ISTA Tears vs Systane
Dry Eye Disease
Primary: Percentage of Participants With Preference for One of the Treatments — 23; 1; 11 Participants
N/A N=42 Investigation of Ocular Signs & Symptoms in Wearers Fitted With Contact Lenses Following Digital Device Use
Visual Performance
Primary: Subjective Overall Comfort — 65.0; 53.6; 61.9 units on a scale
N/A N=80 Initial Performance of a Modified Daily Disposable Contact Lens
Refractive Error
Primary: Incidence (Number) of Ocular Discomfort Device-related Adverse Events (AEs) — 0; 0 Eyes
Phase 2 N=101 A Comfort Study of Brinzolamide 1% / Brimonidine 0.2% Fixed Combination, Brinzolamide 1% and Brimonidine 0.2%
Open-Angle Glaucoma · Ocular Hypertension
Primary: Mean Ocular Discomfort Score — 0.8; 0.4; 0.3 Units on a scale
N/A N=62 Contact Lens Comfort Relative to Meibomian Gland Status
Meibomian Gland Dysfunction
Primary: Comfort as Measured by the Contact Lens Users Experience Questionnaire (CLUE) — 58.67 units on a scale
N/A N=84 Accommodative Relief for Uncomfortable Non-Presbyopes
Asthenopia
Primary: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Score — 14.3; 12.8; 19.0 scores on a scale — p=<0.001
N/A N=20 Acute Comfort and Blur of Systane Ultra and Systane
Dry Eye
Primary: Drop Comfort — 0.55; 0.60 Units on a scale
Phase 4 N=42 The Effect of Xiidra on Comfort and Dryness in Symptomatic Contact Lens Wearers
Dry Eye
Primary: Difference in Contact Lens-related Discomfort at 12 Weeks Compared to Baseline — 71; 11 score on a scale — p=<0.01
Phase 4 N=50 Corneal and Conjunctival Sensitivity and Staining Study
Myopia · Hyperopia
Primary: Corneal Sensitivity — 26.9; 25.5 percent CO2
N/A N=54 SYSTANE® BALANCE Symptoms (OSDI) & Inflammatory Biomarkers
Dry Eye Syndrome
Primary: Ocular Comfort Measured as Mean Change From Baseline in OSDI Score by Visit — -7.85; -12.58; -10.23; -16.74 units on a scale
N/A N=30 Safety and Efficacy of 2 Concentrations of Lubricin vs Sodium Hyaluronate in Ocular Discomfort After Refractive Surgery.
Ocular Discomfort
Primary: Changes From Baseline (Day 1 Pre-dose) in Ocular Tolerability Using a Visual Analogue Scale (VAS) — -22.8; -30.1; -20.9; -20.9 mm — p=0.3474
Phase 2 N=213 LME636 in the Relief of Persistent Ocular Discomfort in Subjects With Severe Dry Eye Disease
Dry Eye
Primary: Mean Change From Baseline in Global Ocular Discomfort Score at Day 71 — -7.9; -3.6 units on a scale
N/A N=46 Treating Contact Lens Discomfort With Orthokeratology
Dry Eye · Contact Lens Complication
Primary: Contact Lens Comfort — 22.03; 9.83 Units on a Scale — p=<0.001
N/A N=80 Initial Performance of a Daily Disposable Contact Lens Featuring Molded Marks
Refractive Error
Primary: Incidence of Ocular Discomfort Device-related Adverse Events (AE) — 0; 1 Events
N/A N=60 Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Contact Lens Wearers
Contact Lens Discomfort · Dry Eye Disease · Meibomian Gland Dysfunction
Primary: Mean Change in the Duration of Subject-reported Comfortable Contact Lens Daily Wear Time (Hours Per Day) — 9.2; 8.5; 7.1 hours per day — p=0.02
N/A N=92 Evaluation of Dryness in a Silicone Hydrogel Daily Disposable Contact Lens
Visual Acuity
Primary: Change From Baseline Comfort Score — 28.99; -0.29 Units on a scale
N/A N=104 Subjective Comfort With Multipurpose Care Solutions in Soft Contact Lens Wearers
Myopia · Astigmatism · Refractive Error
Primary: Change From Baseline (Day 0) in Ocular Comfort Rating at Day 14 — 87.40; 88.79; 81.75; 83.18 Units on a scale
N/A N=35 Performance of DAILIES TOTAL1 Daily Disposable Contact Lenses in Habitual Soft Lens Wearers Who Report Substantial Digital Device Use
Myopia
Primary: Subjective Rating of Comfort After 8 Hours or More of Digital Device Use — 96 score on a scale