Phase 4 N=343 PAIN - Postoperative Analgesia INvestigation
Postoperative Pain
Primary: Postoperative Pain as Assessed by a Numeric Pain Scale (NPS) — 5.05; 5.02 units on a scale — p=0.934
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=38 Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Chronic Pain · Chronic Lower Back Pain · Back Pain
Primary: Changes in Patient Reported Pain and Discomfort — 47; 13; -30; -18 percent change from baseline
N/A N=110 Prometra's Utilization in Mitigating Pain (PUMP)
Intractable Pain
Primary: Demonstrate That Prometra Programmable Pump System Accurately and Safely Delivers Medication in the Intrathecal Space, as Programmed. — 97.8 % of programmed vol…
N/A N=40 Clinical Outcomes Study Using a New Implantable Neurostimulation System for Chronic Intractable Pain
Chronic Pain
Primary: Proportion of Subjects Satisfied With Treatment at 90 Days Post-IPG Implantation — 32 Participants
Phase 4 N=17 Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain
Pain, Intractable · Breakthrough Pain · Chronic Pain
Primary: Change From Baseline in the Numerical Rating Pain Scale (NRS) — 1.87; 1.81 units on a scale
Phase 4 N=36 Determining the Prognostic Value of Continuous Intrathecal Infusion
Lumbar Post-Laminectomy Syndrome · Chronic Low Back Pain · Vertebral Compression Fracture
Primary: Change in Numerical Rating Scale Pain Scores (NRS) With Activity — 8.40; 8.00; 4.13; 4.19 Score on a scale
Phase 4 N=93 Embrace TDD: Post-Market Study to Evaluate Intrathecal Morphine as an Alternative to Systemic Opioids for Chronic Pain
Chronic Non-malignant Pain · Chronic Pain · Pain, Back
Primary: Number of Participants With Clinical Success at the 6-Month Visit — 25 Participants
Phase 3 N=768 A Open-label Study to Evaluate the Safety of TRV130 in Patients With Acute Pain
Acute Pain
Primary: Number of Patients That Experienced a Treatment-emergent Adverse Event — 490 Participants
Phase 3 N=65 An Implantable Spinal Cord Stimulation Pain Management System
Chronic Pain · Pain, Intractable · Pain
Primary: Change in Visual Analog Scale (VAS) Score From Baseline to 2 Week Post Initial Fitting. — 35 participants with > 50% VAS improvement
Early Phase 1 N=22 Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Chronic Pain · Opiate Dependence · Lower Back Pain
Primary: Change in Quantitative Pain Testing Following Active TMS Compared to Baseline — 1.4; .3 Change from Baseline (degrees C) — p=.83
N/A N=5,308 Matrifen® for Therapy of Severe Chronic Pain®
Severe Chronic Pain
Primary: Patient's Assessment of Pain Severity Score — 7.12; 3.32 Units on a scale
N/A N=575 Persistent Pain After CS Delivery
Persistent Pain After Delivery
Primary: Persistent Pain-PERCEIVED STRESS Scores Stratified by the Rate of Recovery — 11.4; 12.9; 15.4 units on a scale — p=<0.01
N/A N=219 Patient Registry of Intrathecal Pain Management in Europe for Prialt (Ziconotide Intrathecal Infusion) and Alternative Drugs for the Management of Severe, Chronic Pain.
Pain Management · Severe Chronic Pain
Primary: Average Overall Change From Baseline (Visit 1) in Visual Analog Scale of Pain Intensity (VASPI) — -3.23; -15.24; -1.50; -18.40 Units on a scale
Phase 4 N=60 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain
Typical Facial Pain · Atypical Facial Pain
Primary: The Proportion of Subjects Reporting at Least 50% Overall Pain Relief — 19; 14; 10; 16 Participants — p=.196
Phase 4 N=25 Erenumab for Idiosyncratic Facial Pain
Facial Pain · Rhinosinusitis
Primary: Change in Mean Number of Days Per Month With Significant Mid-facial Pain or Pressure — -6.0; -5.8 days per month — p=0.96
N/A N=20 VANISH for Chronic Low Back Pain
Chronic Low-back Pain
Primary: Assessment of Opioid Use Via Subject Report — 47.5; 21.75 morphine milligram equivalent
N/A N=525 Integrated Services for Pain: Interventions to Reduce Pain Effectively
Chronic Pain
Primary: Change From Baseline in Average Daily Opioid Dose in Morphine Milligram Equivalents (MME) at Month 12 — -11.6; -6.0 Morphine Milligram Equivalents (MME) — p=0.31
N/A N=140 INTRACEPT: Prospective, Randomized, Multi-center Study Intraosseous Basivertebral Nerve Ablation for Treatment of CLBP
Chronic Low Back Pain
Primary: Difference Between Arms in Least Squared (LS) Mean Change in Oswestry Disability Index (ODI) — -25.3; -4.4 units on a scale — p=<0.001
Phase 3 N=159 IVPCA in the Management of Pain Following Major Intracranial Surgery
Intracranial Surgery
Primary: Hourly Pain Scores — 2.5; 3.6; 3.7; 5.2 units on a scale
N/A N=69 High Pain Intervention in Cesarean Sections
Other Chronic Postoperative Pain
Primary: Severity of Acute Pain — 46; 31 mm — p=0.05
N/A N=105 SCS Programming Study in Treating Intractable Chronic Back Pain (NOVA)
Chronic Back Pain
Primary: Percentage of Subjects Who Respond to DTM-SCS Therapy Compared to Conventional SCS Therapy — 93.5; 36.4 percentage of participants
Phase 4 N=34 Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy
Cerebral Palsy · Hip Dysplasia · Pain, Postoperative
Primary: Opioid Consumption — 0.41; 1.87 mEQ/kg
N/A N=73 A Behavioral Intervention for Depression and Chronic Pain in Primary Care
Chronic Pain · Depression
Primary: Change in Clinically Significant Depressive Symptoms, as Measured by the Montgomery Asberg Depression Rating Scale (MADRS) — 19.37; 20.87; 14.88; 18.67 score on a scale…
Phase 3 N=177 A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy
Palliative Care · Pain · Cancer
Primary: The Change in Mean Pain Numerical Rating Scale (NRS) Score From Baseline to the End of the Treatment. — -1.32; -0.93; -0.73 units on a scale — p=0.014
Phase 2 N=222 PF-06372865 In Subjects With Chronic Low Back Pain
Chronic Low Back Pain
Primary: Change From Baseline in Daily Low Back Pain Intensity (LBPI) Score as Measured by an 11-point Numeric Rating Scale (NRS) at Week 4 — -1.19; -1.03; -1.45 units on a scale
Early Phase 1 N=46 Pain Management in Teeth With Reversible Pulpitis
Reversible Pulpitis · Ibuprofen
Primary: Change in Pain Intensity From Baseline (Pre-Operative) to Immediately During the Procedure (Day 0), Measured by the Visual Analogue Scale (VAS) — 5.05; 0.64 score on a…
Phase 2 N=24 Tariquidar-ondansetron Combination in Neuropathic Pain
Neuropathic Pain
Primary: Concertation-time Profile of Ondansetron in Plasma, Measured by the Area Under the Concentration-time Curve (AUC) — 0.89; 0.87 mg*hr/L — p=0.8651
N/A N=44 Suicide Prevention for Patients With Chronic Pain
Suicide · Chronic Pain
Primary: Social Problem-solving Inventory - Patient Report — 8.12; 3.64 score on a scale
N/A N=30 Early Interventional Treatment for Cancer Pain
Cancer Pain
Primary: Feasibility - Pain Consultation — 29 Participants
N/A N=7 Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia
Postoperative Pain
Primary: Change From Baseline of Surgical Site Pain Level (NRS) at Rest [Percentage of Baseline Pain] — 64; 100; 55; 69 percentage of baseline