Clinical Trial Search

Primary: Number of Participants Responding With at Least a 30% Reduction in 24-Hour Worst Back Pain Severity at the 6-Month Endpoint — 206; 193; 142; 143 participants — p=0.642

Primary: Back-specific Functional Status Using Roland-Morris Disability Questionnaire (RDQ) Scale at 1 Month — 12.0; 13.0 units on a scale — p=0.49

Primary: Pain (Subjective Symptom) — -37.8; -24.5; -40.5; -29.0 mm

Primary: Sum of Pain Intensity Difference Over 3 Days (SPID72) — 139.0; 129.4; 114.2 Scores on a scale

Primary: Visual Analogue Scale — 6.0; 6.8; 5.5; 3.7 units on a scale

Primary: Time Used to Walk 20 m at Maximal Speed. — 14.9; 14.7; 13.4; 15.2 Seconds

Primary: Berg Balance Scale (BBS) — 50.68; 43.13 scores on a scale

Primary: Feasibility of Recruitment and Retention — 66; 64 Participants

Primary: Proportion of Participants With New Vertebral Fractures — 28; 64 Participants (with at least one event) — p=0.000094

Primary: Changes in Lumbar Spine BMD +/- Treatment With Alendronate — 5.28; -1.48 Percent Change

Primary: Number of Participants With Evidence of Cortical Bridging for Fracture Healing — 9; 8 Participants

Primary: Percentage of Change in Trabecular Surface-to-curve Ratio — 9.1; 7.1 Percentage of Change

Primary: Change From Baseline to 3 Months in Mineralizing Surface (MS) /Bone Surface (BS) in the Cancellous Compartment (CC) of the Iliac Crest Bone Biopsies — 12.43; -2.51…

Primary: Osteoarthritis Structural Changes Assessed by Quantitative Magnetic Resonance Imaging With and Without Neuropathic Pain — 14; 7; 5; 1 participants

Primary: Number of Participants That Initiate an Osteoporosis Prescription Medication — 157; 153 Participants

Primary: Mean Percent Change in BMD of the Lumbar Spine From Baseline to Month 12 — .94; 3.52 percent — p=<0.001

Primary: Number Adherent With the Intervention — 29 participants

Primary: Changes in Indices of Bone Turnover — 4418; 3696; 956; 822 months*(ng/ml - baseline ng/ml)

Primary: The Effect of Melatonin (3 mg) or Placebo on the Mean Change in Serum Osteocalcin (OC) Levels in Women After 6 Months, as Compared to Baseline — -0.6; 1.83 ng/mL

Primary: Percentage of Participants With Modeling Based Bone Formation in the Femoral Neck — 100 percentage of participants

Primary: Change From Baseline at 18 Month Endpoint in Lumbar Spine Bone Mineral Density (BMD) — 0.059; 0.028 grams per square centimeters — p=<0.001

Primary: Number of Early Breast Cancer Patients Prescribed Adjuvant Letrozole That Are Vitamin D Deficient and Who Experience Myalgias, Arthralgias and/or Joint Stiffness — 12; 1…

Primary: Change in 6-minute Walk Test — 22; 49 meters

Primary: Sensitivity of the Density Index Against Dual Energy X-ray Absorptiometry for Detecting Osteoporosis — 93.7; 100 percentage of true positives

Primary: Bone Density of the Total Hip — 4.62; -0.19; 3.74; 0.48 Percent change — p=.007

Primary: Weekly Change From Baseline in the 24-Hour Average Pain Rating Using an 11-Point Numerical Likert Scale Patient Diary — -0.36; -0.84; -0.95; -1.54 units on a scale…

Primary: Participants' Level of Low Back Pain-associated Disability as Assessed by Roland Morris Disability Questionnaire (RMDQ) — -1.29; -0.08 score on a scale — p=<0.05

Primary: Percentage Change From Baseline in Lumbar Spine Bone Mineral Density (BMD) at 12 Months — -0.13; -0.62; 1.50; 2.65 Percentage change — p=<=0.001

Primary: Facet Joint High Grade FDG Activity Concordance to Pain — 0.10 concordance correlation coefficient

Primary: Acute Pain Assessed by Numeric Pain Score — 5.61; 5.93 score on a scale — p=0.493