Clinical Trial Search

Primary: Percentage of Patients Achieving Corneal Healing (<0.5 mm2 Lesion Size) of the Persistent Corneal Epithelial Defect at 4 Weeks — 5 Participants

Primary: Patients With Corneal Epithelial Healing Time Within 14 Days — 78; 73 participants

Primary: Number of Days to Complete Re-epithelialization — 4.6; 4.1 days to complete re-epithelialization

Primary: Number of Participants With Clearing of Corneal Fluorescein Staining at Week 5 at Week 5 — 5; 7; 12 Participants

Primary: Number of Eyes With Corneal Graft Failure Within 3 Years of Surgery — 30; 49 Eyes — p=0.02

Primary: Number of Participants With Complete Healing of Corneal Epithelial Defect at Day 3 — 20; 25 Participants

Primary: Number/Percentage of Patients Who Achieved Corneal Epithelial Healing at NGF0120 Week 8 (EoT NGF0120=Baseline NGF0122) and Remained Healed at Month 24 and Month 30 of…

Primary: Time From Surgery to Device Loss or Replacement — 95; 34 median weeks from surgery to removal

Primary: The Correlation Between Mean Change From Baseline in Corneal Fluorescein Staining (CFS) Score and Symptom Assessment iN Dry Eye (SANDE) Symptoms Score at Each Visit…

Primary: Difference Between Treatment Groups in the Change From Baseline to Month 6 in Kmax — -0.3; 0.6 Diopters — p=0.0004

Primary: Number of Participants With Pain Score of Four or Greater. Score Range: 0-10, Higher Score Corresponds to More Pain. — 0 Participants

Primary: Incidence of Treatment-Emergent Adverse Events — 0 events

Primary: Mean Corneal Thickness — 570.54; 560.73 microns — p=0.25

Primary: Central Corneal Endothelial Cell Density (ECD) at Week 12 — 530.86; 468.02; 228.05 cells/mm2 — p=0.0065

Primary: Best Spectacle Corrected Visual Acuity (BSCVA) — 1; 3; 7; 9 Participants

Primary: Endothelial Cell Loss — 28; 36 percentage of endothelial cell loss — p=0.10

Primary: Change in Central Corneal Thickness — -23; -2 microns

Primary: Graft Failure — 32; 15 eyes

Primary: Change in Maximum Keratometry From Baseline to 6 Months After Treatment — 0.76; 0.97 diopters

Primary: Incidence and Severity of Ocular TEAEs. — 3; 6; 1; 1 Participants

Primary: Number of Participants Developing a Corneal Inflammatory Event (CIE) — 6; 7 participants

Primary: Change in Intraocular Lens Calculation — 1.56; 0.94 D

Primary: Changes in Corneal Re-epithelialization (Time) — 5.39; 5.34 days

Primary: Number of Pterygium Hyperemia Responders at Week 16 — 6; 8 Participants

Primary: Percentage Change From Baseline of Corneal Swelling 8 Hours Post Fit — 0.07; -0.02; 0.14; -0.06 percentage of change from baseline

Primary: Change From Baseline in Mean Endothelial Cell Density — -35.86 cells/millimeter squared

Primary: Lid-Parallel Conjunctival Folds (LIPCOF) — 1.95; 1.75; 1.70; 1.40 Score

Primary: Ocular Symptoms and Signs Total Composite Score — 29.1; 4.7 units on a scale — p=0.002

Primary: Changes in Corneal Thickness at 1 Millimeter — 730; 760; 700; 720 micrometer

Primary: Patient-Assessed Ocular Itching — 2.2; 2.2; 0.5; 0.5 units on a scale