Clinical Trial Search

Primary: The Primary Endpoint for This Study Will be a Change From Baseline in the Number of Pigmented Lesions on Skin Previously Covered by Psoriatic Plaques. — 0 participants

Primary: Pigmented Lesion Improvement by Blinded Evaluation — 41 Observations

Primary: Percentage of Participants With Change of Treated Lesions — 44; 44; 13 % of participants

Primary: Change in Wrinkles From Baseline to 12 Weeks Post-study Treatment Assessed by Blinded Photographic Evaluation Using 9-Point Fitzpatrick Wrinkle Scale

Primary: Percent Clearance of All Lesions — 88; 96; 92.5; 0 percentage of lesion clearance

Primary: Clearance Based on Photographic Scale — 2; 2; 4; 7 Participants

Primary: Sensitivity and Specificity — 98.2; 9.5 Ratio * 100 — p=0.05

Primary: Change in Spots - Front of Face (Part 1) — 53.60; 58.47; 56.44 spots

Primary: Maximum Tolerated Dose — 8 J/cm2

Primary: Pigmented Lesion Improvement by Blinded Evaluation — 41 observations

Primary: Blanching of Port Wine Stain Birthmark — 16 participants

Primary: Change From Baseline in a* and E at 8 Weeks — 1.27; 0.43; 4.08; 2.59 units on a scale

Primary: Change in Dyspigmentation Spots — 48.3; 46; 42.2; 42.5 Dyspigmentation Spots

Primary: Median VAS Improvement Score as Assessed by Blinded Physician Reviewers — 1.5 units on a scale — p=<0.0001

Primary: Number of Accumulated New Skin Lesions at Month 3 — 65; 103 new skin lesions — p=0.0120

Primary: Photographic Evaluation Using the Blinded Global Aesthetic Improvement Scale — 0; 1; 3; 3 Participants

Primary: Percentage of Participants With Histologically Confirmed Complete Response (CR) — 67; 18 percentage of participants — p=<0.001

Primary: The Extent of Latanoprost, Bimatoprost and Travoprost Induced Periocular Skin Hyperpigmentation Over a One Year Time Course in Newly Diagnosed Primary Open Angle and…

Primary: Frequency of BRAF Mutations Among Nevi — 6; 19 BRAF mutations

Primary: Change in Overall Improvement of Poikiloderma of Civatte (POC) From Baseline at 12 Weeks — 11.01; 6.03; 8.51; 5.89 percentage

Primary: Correct Identification of Baseline Photographs vs. Photographs Taken 3 Months Post Last Treatment — 80 % of photos correctly identified

Primary: Percent Reduction in the Number of Hand Lentigines as Assessed by Blinded Reviewers.

Primary: Number of Participants With Histologically Confirmed Complete Response — 25; 11 Participants

Primary: Number of Participants With Severity of Photodamage — 0; 0; 1; 0 Participants

Primary: Improvement of the Inflammatory Lesions (Papules, Pustules, Nodules), Erythema, and Telangiectasia of Rosacea as Assessed by the Investigator's Global Assessment (IGA)…

Primary: Percent Change in Blanching of Port Wine Stain — 6; 5 percentage

Primary: Lab* Values of Lesional Area Using Dermoscopy and ImageJ — 68.850; 72.103; 73.147; 72.633 unitless

Primary: Tumor Clearance — 2; 2; 5 Participants

Primary: Complete Clearance Rate — 16; 15; 10; 12 AK Fields

Primary: Part 1: Photosensitizer Uptake and Conversion to Protoporphyrin IX — 304 Densitometry units/micrometer squared — p=0.0001