Phase 4 N=200 Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone
Post-operative Pain Control
Primary: Post-operative Average Pain Score — 2.82; 3.58 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=106 Oral Gabapentin Versus Placebo for Treatment of Postoperative Pain Following Photorefractive Keratectomy
Postoperative Pain
Primary: Level of Pain — 3.85; 4.09 units on a scale
N/A N=30 Post Photorefractive Keratectomy (PRK) Use of an Eye Shield for Maintaining Vision and Mitigating Pain
Pain · Vision Nearsighted
Primary: Number of Participants With Pain Score of Four or Greater. Score Range: 0-10, Higher Score Corresponds to More Pain. — 0 Participants
Phase 2 N=35 Cannabinoid vs Opioid for Photorefractive Keratectomy Pain Control
Photorefractive Keratectomy · Myopia · Hyperopia
Primary: Pain as Recorded by the FACES Scale (Maximum) After First Surgery — 1.33; 1.27 units on a scale — p=0.538
Phase 2 N=40 Study of SAF312 as an Eye Drop for Treatment of Eye Pain Following Photorefractive Keratectomy (PRK) Surgery
Postoperative Ocular Pain After PRK Surgery
Primary: Visual Analog Scale (VAS) Pre-dose Pain Assessment — 34.63; 45.76 score on a scale — p=0.005
N/A N=130 A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery
Postoperative Pain
Primary: Clinical Efficacy — 0.89; 1.33; 7.56; 10.34 units on a scale — p=0.180
Phase 4 N=131 Loteprednol vs. Prednisolone and Fluorometholone
Intraocular Pressure · Corneal Opacity
Primary: Change in Intraocular Pressure (IOP) From Baseline Through Month 3 — 14.38; 14.30; 13.67; 13.28 mmHg
N/A N=40 Sutureless Cryopreserved Amniotic Membrane Graft (ProKera) and Wound Healing After Photorefractive Keratectomy
Corneal Wound Healing
Primary: Number of Days to Complete Re-epithelialization — 4.6; 4.1 days to complete re-epithelialization
Phase 3 N=43 Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?
Dry Eye
Primary: Severity of Dry Eye Symptoms as Assessed by the Dry Eye Questionnaire - 5 (DEQ5) — 6.6; 4.5 score on a scale
N/A N=50 Postoperative Subtenons Anesthesia for Postoperative Pain in Pediatric Strabismus Surgery
Strabismus
Primary: Average Pain Score Over the First 30 Post-operative Minutes Using the CHEOPS Scale — 6.36; 6.57; 6.58 units on a scale
Phase 4 N=96 Study to Evaluate the Efficacy of Lagricel® Ofteno PF Compared to Thealoz® Duo After Photorefractive Keratectomy
Photorefractive Keratectomy · Corneal De-epithelialization
Primary: Changes in Corneal Re-epithelialization (Time) — 5.39; 5.34 days
Phase 3 N=178 Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification
Cataract
Primary: Visual Ability (VA) — 0.91; 0.87 units on a scale (LogMAR) — p=0.065
N/A N=30 Safety and Efficacy of 2 Concentrations of Lubricin vs Sodium Hyaluronate in Ocular Discomfort After Refractive Surgery.
Ocular Discomfort
Primary: Changes From Baseline (Day 1 Pre-dose) in Ocular Tolerability Using a Visual Analogue Scale (VAS) — -22.8; -30.1; -20.9; -20.9 mm — p=0.3474
Phase 4 N=57 Postoperative Pain Control Following Vitreoretinal Surgery
Retinal Detachment · Proliferative Vitreoretinopathy · Retinoschisis
Primary: Mean Pain Score — 2.9; 3.8 units on a scale
Phase 2 N=150 Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)
Chronic Ocular Pain
Primary: Change From Baseline at Week 12 in Ocular Pain Severity Visual Analog Scale (VAS) — -23.7; -21.7; -25.3 Scores on a scale — p=0.930
Phase 3 N=520 Safety and Efficacy of KPI-121 in Subjects With Postsurgical Inflammation and Pain
Post Surgical Ocular Inflammation and Pain
Primary: Complete Resolution of Anterior Chamber (AC) Cells at Day 8 — 54; 32 Participants — p=0.0105
Phase 4 N=80 GenTeal in Perioperative Treatment of Laser Assisted in Situ Keratomileusis LASIK Patients
Corneal Epithelium Defect
Primary: Epithelial Healing After Laser Assisted in Situ Keratomileusis (LASIK) Surgery — 4.3; 3.5; 9.2; 9.0 Clock Hours
Phase 4 N=14 Using Triamcinolone Acetonide to Reduce Pain After Scleral Buckle Surgery
Retinal Detachment
Primary: Post Operative Pain Day 1 — 2.2; 1.0 score on a scale
N/A N=300 Patient Reported Outcomes With WaveLight LASIK
Myopia
Primary: Patient Satisfaction — 285 Participants
Phase 2 N=61 Processed Amniotic Fluid (PAF) Drops After Photorefractive Keratectomy (PRK)
Photorefractive Keratectomy
Primary: Safety - Adverse Events Including Serious Adverse Events — 1; 1 Participants — p=1.000
Phase 4 N=20 Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study
Keratoconus, Unstable · Collagen Crosslinking · Postoperative Pain
Primary: Change in Degree of Postoperative Pain Between Groups From Date of Surgery Through 1 Month Post-CXL (Day of Surgery, Postoperative Days 1 ,3, 7, Postoperative Weeks 2 ,3…
N/A N=176 A Safety and Effectiveness Study of PRK Using the ALLEGRETTO WAVE® EYE-Q Excimer Laser System
Myopia · Astigmatism
Primary: Percentage of Eyes Achieving Uncorrected Visual Acuity (UCVA) of 20/40 or Better at Refractive Stability in Eyes With Best Spectacle-corrected Visual Acuity (BSCVA) of…
Phase 2 N=109 RTA 408 Ophthalmic Suspension for the Treatment of Ocular Inflammation and Pain Following Ocular Surgery
Inflammation and Pain Following Ocular Surgery
Primary: Absence of Anterior Chamber Cells at Day 15 (Visit 5) — 10; 12; 11; 27 Participants — p=0.4543
N/A N=228 Evaluate the Safety and Efficacy of a New Artificial Tear for Use After LASIK Surgery
Dry Eye Syndrome
Primary: Post LASIK Dry Eye Symptoms as Measured by Ocular Surface Disease Index (OSDI©) Score at Day 90 — 8.32; 6.43 Scores on a Scale
Phase 4 N=94 No Drop Post-Op Cataract Surgery
Cataract
Primary: Best Corrected Visual Acuity (BCVA) (Pre-op) — .28 LogMar
Phase 1 N=165 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Corneal Epithelial Defect · Diabetic Retinopathy · Penetrating Keratoplasty
Primary: Patients With Corneal Epithelial Healing Time Within 14 Days — 78; 73 participants
Phase 4 N=40 The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study
Refractive Surgery
Primary: Patient Preference — 14; 4; 2 Participants
N/A N=87 Occurrence of Post-op Pain Following Gentlewave
Root Canal Infection · Endodontic Disease · Endodontic Inflammation
Primary: Level of Post-operative Pain (2018-2019) — 23.2; 11.56 score on VAS scale
Phase 4 N=160 Management of Postoperative Pain After Total Knee Replacement.
Postoperative Pain · Knee Replacement Arthroplasty
Primary: Post-Operative Pain — 2.9; 3.0 units on a scale — p=0.76
Phase 3 N=211 Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-1)
Cataract
Primary: Anterior Chamber Cell Grade — 67; 18 Participants