Early Phase 1 N=6 Ketamine for Depression Relapse Prevention Following ECT
Depression
Primary: Completion Rate for Randomised Treatment — 0; 0 Participants
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=96 Ketamine for Reduction of Alcoholic Relapse
Primary Alcohol Use Disorder
Primary: Relapse Rates — 13; 15; 14; 18 Participants
Phase 4 N=1,806 A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health
Depression · Anxiety · Post Traumatic Stress Disorder
Primary: 9-item Patient Health Questionnaire (PHQ-9) — -3.23 units on a scale
Phase 2 N=24 Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects
Healthy Volunteers
Primary: Change in The Profile of Mood States - Bipolar Version (POMS - Bi) Composed-Anxious Subscale — -6.8; -11.9 score on a scale
Early Phase 1 N=18 Ketamine Infusion for Social Anxiety Disorder
Social Anxiety Disorder
Primary: Visual Analogue Scale for Anxiety Symptoms (VAS-anxiety) — 12.1; 19.6 units on a scale
Phase 4 N=9 Ketamine Treatment Effects on Synaptic Plasticity in Depression
Major Depressive Disorder
Primary: Synaptic Density — 2.40; 2.32 Ratio
Phase 4 N=82 Ketamine in the Treatment of Suicidal Depression
Major Depressive Disorder · Suicidal Ideation
Primary: Change in Scale for Suicidal Ideation — -3.66; -8.62 units on a scale
Phase 2 N=43 Ketamine + Mindfulness for Depression
Depression, Unipolar
Primary: Montgomery-Asberg Depression Rating Scale — 12.50; 13.30 score on a scale
Phase 2 N=16 Ketamine and Nitroprusside for Depression
Depression
Primary: Montgomery-Asberg Depression Rating Scale — 13.4; 14.2 score on a scale
Phase 2 N=73 Optimization of IV Ketamine for Treatment Resistant Depression
Major Depressive Disorder (MDD) · Treatment Resistant Depression (TRD)
Primary: MADRS — 14.77; 22.72 units on a scale
Phase 3 N=46 Lamotrigine in Reducing Psychologic Side-Effect of Perioperative Ketamine
Reducing Psychological Side Effects of Ketamine
Primary: Psychologic Side-effects — 4; 4 score on a scale — p=0.08
N/A N=37 Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Major Depressive Disorder
Primary: Hamilton Depression Rating Scale - Suicidal Ideation (HDRS-SI) — 1.6; 1.6 units on a scale
Phase 4 N=40 Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids
Psychoses, Substance-Induced
Primary: Brief Psychiatric Ratings Scale (BPRS) Positive Symptom Subscale Score — 0.00; 0.00; 1.40; 1.00 Scale of 0-6
Phase 2 N=67 Rapid Antidepressant Effects of Ketamine in Major Depression
Depression · Mood Disorders · Major Depresssion
Primary: MADRS Score - Baseline — 1.17; 1.48; 33.83; 31.82 units on a scale
Phase 2 N=12 Ketamine for Depression and Suicide Risk
Depression · Suicide
Primary: MADRS Total Score at Baseline and Last Acute Phase Observation — 29.4; 29.4; 29.4; 15.9 units on a scale — p=<0.01
Phase 2 N=41 Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Stress Disorders, Post-Traumatic · PTSD · Depression
Primary: Impact of Event Scale - Revised (IES-R) — 25.76; 36.32 units on a scale
Phase 2 N=16 Ketamine for Suicidality in Bipolar Depression
Bipolar Disorder · Major Depressive Episode · Suicidal Ideation
Primary: Change in Suicidal Ideation Measured With the Beck Scale for Suicidal Ideation — -12.4; -6.7 units on a scale
Phase 2 N=154 Intravenous Ketamine Plus Neurocognitive Training for Depression
Depression
Primary: Montgomery Asberg Depression Scale — 19.72; 22.87; 23.51 score on a scale — p=.0004
Phase 4 N=16 Ketamine for Depression: An MRI Study
Depression · Anxious Depression · Major Depressive Disorder
Primary: Change in Hamilton Depression Rating Scale (HDRS) From Baseline/Minute 0 to 4 Hours Post-infusion. — -9.625 score on a scale — p=<0.01
Phase 2 N=65 Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
Major Depressive Disorder · Alcohol Use Disorder
Primary: Number of Participants With 50% or Greater Improvement in MADRS Scores From Baseline — 15; 9; 13 Participants
Phase 4 N=55 Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects
Pain, Acute · Dissociation
Primary: Side Effect Rating Scale for Dissociative Anesthetics (SERSDA) Composite Score — 1.88; 0.42; 1.17; 3.67 Scores on a Scale — p=<0.001
Phase 2 N=5 Low Dose Intravenous Ketamine in Treatment Resistant Depression Patients
Treatment Resistant Depression
Primary: Cortical Excitability in the Dorsolateral Prefrontal Cortex (DLPFC) as Assessed by Transcranial Magnetic Stimulation-evoked Activity Detected by Electroencephalography…
Phase 2 N=38 Ketamine in the Treatment of Depression
Major Depressive Disorder
Primary: Number of Responders 24-hours Post-ketamine Infusion — 3; 1; 3; 2 participants
Phase 2 N=12 Ketamine and Prolonged Exposure in PTSD
Post-traumatic Stress Disorder
Primary: Change in Severity of Post-traumatic Stress Disorder (PTSD) Symptoms — 15.3 units on a scale
Phase 3 N=30 Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder (PTSD)
Primary: Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) — 22.5; 33.2 score on a scale
Phase 2 N=8 Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
Depression
Primary: Evaluate the Effects of Ketamine on Depressive Symptomatology by Measuring Change in Score on the Montgomery-Asberg Depressive Rating Scale — 28.82; 25.20 units on a scale
Phase 1 N=25 Ketamine as an Adjunctive Therapy for Major Depression
Major Depressive Episode · Unipolar Depression · Bipolar Depression
Primary: The Hamilton Rating Scale for Depression-24 Item Version (HRSD-24) — 11.2; 16.6 score on a scale
Phase 2 N=58 Efficacy of Repeated Ketamine Infusions for Treatment-resistant Depression
Treatment-resistant Depression
Primary: Change From Baseline in Montgomery-Asberg Depression Rating Scale (MADRS) Score After 12 Days of Treatment — 21.0; 17.2 units on a scale
Phase 3 N=25 Ketamine to Prevent PPD After Cesarean
Postpartum Depression
Primary: The Prevalence of Postpartum Depression in the Study Population, as Defined as EPDS Greater Than 10 Out of 30 — 4; 2; 5 Participants
Phase 4 N=17 Ketamine Infusion for Adolescent Depression and Anxiety
Major Depressive Disorder · Anxiety Disorder
Primary: Montgomery-Asberg Depression Rating Scale Score 1 Day After Infusion — 15.44; 24.13 units on a scale