N/A N=15 Spinal Cord Stimulation for Restless Legs Syndrome
Restless Legs Syndrome · Neuropathic Pain
Primary: Percent Change MSNA Burst Frequency From Baseline to 60 Minutes — -29; -24 Percent change MSNA burst frequency
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=240 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA
CRPS
Primary: Epidural Medication Consumption Rate — 6.40; 5.77 mL/h — p=0.003
N/A N=48 REnal SympathetiC Denervation to sUpprEss Tachyarrhythmias in ICD Recipients
Ventricular Tachycardia
Primary: Time to First Event Requiring ICD Therapy or Incessant VT — 177.2; 148.66 days
Phase 2 N=22 3D Augmented Reality Mirror Visual Feedback Applied to the Treatment of Unilateral Upper Extremity Neuropathic Pain.
Neuralgia
Primary: Pain on the Visual Analog Scale (VAS) — 6.4; 4.0 units on a scale
N/A N=66 "Liposomal Encapsulated Vitamin C in Complex Regional Pain Syndrome"
Complex Regional Pain Syndrome I of Lower Limb
Primary: Number of Participants Operated for Complex Regional Pain Syndrome Who Had Transposition of Anterior Tibial Tuberosity — 1; 0; 2 participants
N/A N=8 Peripheral Sensory Input in Central Post Stroke Pain (CPSP)
Central Post Stroke Pain
Primary: Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block. — 6.5; 0.0 units on a scale
N/A N=152 A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain
Chronic Lower Limb Pain
Primary: Primary Composite Endpoint - Treatment Success — 81.2; 55.7 percentage of subjects — p=<0.0001
Phase 3 N=318 Safety of Intravenous Neridronic Acid in CRPS
Complex Regional Pain Syndrome
Primary: Number of Participants With Occurrence of Any Treatment Emergent Adverse Event (TEAE) — 277; 27; 275; 267 Participants
N/A N=38 Endovascular Denervation Improves Limb Ischemia in Patients With Peripheral Artery Disease
PAD
Primary: Change of Ankle Brachial Index (ABI) at 6-month Post-procedure. — 0.24; 0.44 ratio
N/A N=17 REnal Sympathetic dEnervaTion as an a Adjunct to Catheter-based VT Ablation
Ventricular Tachycardia
Primary: Freedom From First Event Requiring ICD Therapy — 62.5; 50; 62.5; 37.5 probability of freedom
N/A N=22 Investigation of the Efficacy of tDCS in the Treatment of Complex Regional Pain Syndrome (CRPS) Type 1
Reflex Sympathetic Dystrophy
Primary: Pain Severity — 22.18; 23.36; 18.00; 23.82 units on a scale — p=0.065
N/A N=26 Surgical Treatment of Post-surgical Mastectomy Pain Utilizing the Regenerative Peripheral Nerve Interface
Post-Mastectomy Chronic Pain Syndrome
Primary: Change in Pain Level — 6.9; 0.6; 4.4; 2.5 score on a scale
N/A N=133 Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study)
Restless Legs Syndrome
Primary: Number of Subjects for Which the Clinician Reported "Much Improved" or "Very Much Improved" on the Clinical Global Impressions-Improvement (CGI-I) Scale for TOMAC…
Phase 3 N=44 Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome
Complex Regional Pain Syndrome
Primary: Pain Score — 5.9; 6.0; 6.5; 6.8 score on a scale — p=0.19
N/A N=8 C-RFA of Residual Limb Neuroma
Phantom Limb Pain · Neuroma Amputation
Primary: Numeric Rating Scale (NRS) for Pain at 6 Months — 4 Participants
N/A N=20 Transcranial Magnetic Stimulation (TMS) for CRPS
Complex Regional Pain Syndrome (CRPS)
Primary: Present Pain Intensity — 6.5; 6.3; 3.1; 3.7 Units on a scale
N/A N=64 Remote Ischemic PreConditioning Effect on Postsurgical Pain
Pain
Primary: Comparison of Pain Intensity and Unpleasantness Postoperatively — 4.82; 4.83; 4.05; 4.81 units on a scale
N/A N=10 Botulinum Toxin in the Treatment of Raynaud's
Raynaud's Syndrome
Primary: Mean Digital Temperature Difference From Baseline — 1.30 Celsius
N/A N=21 Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS
Spinal Cord Injuries · Amyotrophic Lateral Sclerosis
Primary: Percent Change of Electromyographic Responses After Remote Ischemic Conditioning (RIC) Plus Hand Isometric Exercise — 17.4; 22.2; -19.2; 79.7 change (%) from baseline
N/A N=22 Nociceptive Pain Fiber Response
Painful Peripheral Diabetic Neuropathy
Primary: Changes in Small Nerve Fiber Density by Assessment of a Skin Biopsy Comparing Baseline to Day 60 — .1; .1 nerve fibers / mm squared
Phase 4 N=5 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome
Shoulder Hand Syndrome · Complex Regional Pain Syndromes
Primary: Number of Participants Demonstrating Tolerability of Suprascapular and Median Nerve Blocks — 5 Participants
N/A N=4 TMS for CRPS - Pilot Study
Complex Regional Pain Syndrome (CRPS)
Primary: Change in Pain — 5.2; 0.7 units on a scale
N/A N=4 Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees
Phantom Limb
Primary: Stimulation Thresholds to a Variety of Stimulus Parameters — 2.13 milliamps
N/A N=158 Central Nervous System Amplification in Lumbar Failed Back Surgery Syndrome
Chronic Pain
Primary: Clinical Pain Severity - 50% Reduction Responders vs Nonresponders — -83; 0 percentage of change
Phase 3 N=65 An Implantable Spinal Cord Stimulation Pain Management System
Chronic Pain · Pain, Intractable · Pain
Primary: Change in Visual Analog Scale (VAS) Score From Baseline to 2 Week Post Initial Fitting. — 35 participants with > 50% VAS improvement
Phase 3 N=140 Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery
Breast Cancer Patient
Primary: Change in Neuropathic Pain Score at 2 Months (Numeric Rating Scale 0-10) — 4.1; 4.6 units on a scale
N/A N=161 Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain
Neuropathic Pain · HIV Neuropathy · HIV/AIDS
Primary: Gracely Pain Scale (GPS) — -2.51; -1.96; -2.38; -0.99 GPS pain score on a scale
N/A N=58 Observational, Post Market Study in Treating Chronic Upper Extremity Limb Pain
Upper Limb · Pain
Primary: Percentage of Implanted Subjects Who Respond to DTM SCS Therapy at 3-months — 100 percentage of individual responder
N/A N=94 Bioness® StimRouter™ Neuromodulation System for Chronic Pain Therapy
Chronic Pain
Primary: Brief Pain Inventory (BPI): Number of Participants With a Pain Reduction of Greater Than or Equal to 30% — 17; 5 participants — p=0.0048
N/A N=28 Electrical Stimulation for the Treatment of Post-Stroke Shoulder Pain
Shoulder Pain
Primary: Pain Intensity (Trial Stage) — 8.2; 6.1; 5.0; 2.1 score on a scale