Phase 4 N=41 Surgical Debulking of Pituitary Adenomas
Pituitary Adenoma
Primary: Percentage of Responders (Primary Medical Treatment in Arm 1, Primary Surgical Treatment in Arm 2) — 6.7; 50 percentage of participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=72 Balloon Sinus Dilation In Office or OR
Chronic Sinusitis
Primary: Mean Intra-patient Change in SNOT-20 Score at 24 Weeks Post-procedure Compared to Baseline — -1.25; -1.35 scores on a scale
N/A N=88 Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes
Type 2 Diabetes Mellitus · Obesity
Primary: Fasting Plasma Glucose <126 mg/dL and HbA1c < 6.5% at Three Years of Follow-up. — 13; 5; 42; 0 % of patients — p=0.60
N/A N=40 Surgical Theater's Surgery Rehearsal Platform
Cerebral Aneurysm Unruptured · Cerebral Aneurysm Ruptured
Primary: Aneurysm Clip Time
N/A N=199 S1316, Surgery or Non-Surgical Management in Treating Patients With Intra-Abdominal Cancer and Bowel Obstruction
Constipation, Impaction, and Bowel Obstruction · Unspecified Adult Solid Tumor, Protocol Specific
Primary: Number of Days Alive and Outside of the Hospital — 42.6; 43.9; 54.8; 52.7 days — p=0.50
N/A N=4,914 Maximizing Trichiasis Surgery Success
Trichiasis · Surgery
Primary: Number of Eyes With Presence of Post-Operative Trichiasis Within 12 Months — 347; 504; 298 eyes — p=0.039
N/A N=150 Gastric Procedures for Obesity
Morbid Obesity
Primary: Change in Body Weight — -21.4; -36.6; -7.0 kg
N/A N=7 Surgery With or Without Adjuvant Stereotactic Body Radiotherapy
Head and Neck Cancer
Primary: 1-year Local Control — NA; NA months
Phase 3 N=554 Esomeprazole (NEXIUM) vs. Surgery
Gastroesophageal Reflux
Primary: Number of Participants With Treatment Failure at 5 Years — 33; 19 participants
N/A N=30 Simulation-based Arthroscopic Surgery Study
Arthroscopy Training
Primary: Number of Hand Movements Required by Participants to Perform a Diagnostic Arthroscopy of the Knee in Theatre — 544; 893 hand movements
N/A N=266 Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma
Sarcoma
Primary: Number of Patients With Abdominal Recurrence or Death — 72; 73; 61; 60 Participants — p=0.955
Phase 4 N=234 Basal Bolus Insulin Versus SSRI in Type 2 Diabetes Undergoing General Surgery
Type 2 Diabetes · Inpatient Hyperglycemia
Primary: Mean Blood Glucose Concentration — 145; 172 mg/dl
N/A N=50 Bariatric Surgery for Morbid Obesity
Obesity · Morbid Obesity
Primary: Size of Adipocytes — 73.4; 99.0; 103.0 µm
N/A N=9 Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy
Emphysema
Primary: Count of Patients With Grade 3 or Higher Adverse Events. — 3 Participants
Phase 4 N=34 Octylseal Surgical Adhesive in General Surgery
Wounds
Primary: Wound Length Closure — 28.97; 21.00 milimeters
N/A N=94 The Use of a High-frequency Ultrasonic Knife in Breast Cancer Surgery
Breast Cancer
Primary: Drainage Volume — 182.6; 525.2 milliliters — p=<0.05
N/A N=60 SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
Peritoneal Surface Malignancy · Postoperative Adhesion · Bowel Obstruction
Primary: Incidence of Major Intra-abdominal Complications — 4; 11 Participants
N/A N=89 A Study to Evaluate Two Different Surgical Methods for Treatment for Abdominal Wall Diastasis
Abdominal Hernias and Other Abdominal Wall Conditions · Post-operative Pain · Recurrence
Primary: Recurrence of Diastasis One Year Post-operatively That Indicated by CT Scan or Clinical Investigation. — 2; 3; 26 Participants
N/A N=446 PCORI-1502-27462 Navigating High Risk Surgery: Empowering Older Adults to Ask Questions That Inform Decisions About Surgical Treatment
Communication
Primary: Patient Engagement in Decision Making Measured by Clinic Visit Transcript Coding for Number of and Types of Questions Raised — 68; 55; 95; 89 Participants — p=0.353
N/A N=3,000 REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery
Major Abdominal Surgery
Primary: Number of Participants With Disability-free Survival — 1232; 1223 Participants
N/A N=72 Randomized Comparison of Laparoscopic Sleeve Gastrectomy and Gastric Bypass for Morbid Obesity
Morbid Obesity · Metabolic Syndrome X · Diabetes Mellitus
Primary: Excess Weight Loss From Baseline — 67.8; 64.2 percentage of EWL
N/A N=90 Primary Operation in SYnchronous meTastasized InVasivE Breast Cancer
Synchronous Metastasized Breast Cancer · Circulating Tumor Cells
Primary: Overall Survival (OS) — 34.6; 56.2 months — p=0.042
N/A N=50 Surgical Trial Comparing LIGASURE Assisted Recto-Sigmoid Resection and Omentectomy Compared to Stand
Epithelial Ovarian Cancer
Primary: Surgical Time — 417; 338 SECONDS
N/A N=700 Repeat Surgery for Patients With Post-operative Trachomatous Trichiasis Trial
Trichiasis · Surgery
Primary: Number of Eyelids With Post-operative Trichiasis Within 12 Months — 94; 120 Eyelids — p=0.07
Phase 3 N=655 Comparison of Surgical Procedures to Reduce Urinary Stress Incontinence
Urinary Incontinence
Primary: 24 Month Cumulative Success Rate Computed From Kaplan Meier Time-to-event Analysis (Reported as Percent Success). — 38; 47 % success at 24 months — p=0.01
N/A N=24 Endoscopic Surgery for Bariatric Revision After Weight Loss Failure
Morbid Obesity · Weight Loss
Primary: Mean Weight Loss — 13.3 Pounds
N/A N=234 The SURGICEL® Powder Mild or Moderate Parenchymal or Soft Tissue Intraoperative Bleeding (China Study)
Hemorrhage
Primary: Hemostatic Success at 5 Minutes — 109; 103 Participants — p=<0.0001
N/A N=760 Observational Study of Anti-Reflux Surgery
GERD · Gastroesophageal Reflux · Gastro Esophageal Reflux
Primary: Gastroesophageal Reflux Disease Health Related Quality of Life Outcome (GERD-HRQL) — 4.2; 4.9 score on a scale
N/A N=80 3D Versus 2D Laparoscopic Ovarian Cystectomy
Surgical Procedure, Unspecified
Primary: The Duration of Laparoscopic Ovarian Cystectomy — 51.6; 47.6 minutes — p=0.198
N/A N=256 Early Surgery or Standard Palliative Therapy in Treating Patients With Stage IV Breast Cancer
Breast Cancer · Stage IV Breast Cancer
Primary: 3-year Overall Survival Rate — 67.9; 68.4 percentage of participants — p=0.32