Clinical Trial Search

Primary: Change From Baseline on the Analogue Rating of Tinnitus Awareness. — -4.08; -4.70; -9.82; -9.89 units on a scale — p=.04

Primary: Change in TFI (Tinnitus Functional Index) After Treatment or Sham Compared to Baseline — -10.08; -5.40; 0.95; -4.34 units on a scale — p=<0.05

Primary: Change in Objective Tinnitus Loudness — -6.1; -9.5; -10.2; -11.0 decibels sensation level (dB SL)

Primary: Tinnitus Functional Index — 57.7; 39.6 score on a scale

Primary: Change in Short Term Relief of Tinnitus as Measured by the Tinnitus Handicap Inventory — -31 score on a scale

Primary: Tinnitus Questionnaire (TQ, Goebel and Hiller 1998) Total Score Change From Baseline to End of Treatment — 13.6; 3.7 absolute TF-score change

Primary: Brain Speed Test — -0.09 z-score

Primary: Tinnitus Functional Index Change — 53.31; 44.10; 64.93 units on a scale

Primary: Change in PET Asymmetry Index — 1.2 ratio

Primary: Number of Participants With Treatment-Emergent Adverse Events (TEAE) — 1 Participants

Primary: Change in Tinnitus Functional Index (TFI) Score — -13.8; -2.9 units on TFI scale; change from baseline

Primary: Change in Tinnitus Functional Index (TFI) Score — -1.8; -2.5 score on a scale

Primary: Resting-State Functional MRI — 0.55; 0.35; 0.29; 0.59 Z-Score — p=0.01

Primary: Tinnitus Functional Index (TFI); Measure of Tinnitus Distress — 48.7; 50.52; 32.13; 28.95 score on a scale

Primary: Average Change (Baseline-End of Treatment) Tinnitus Handicap Inventory (THI) — 10.7 units on a scale

Primary: Tinnitus Handicap Inventory (THI) — 37.9; 45.1; 42.67; 26.0 units on a scale of 0-100 — p=<0.05

Primary: Tinnitus Distress Rating — 5.71; 5.82; 5.36; 5.46 units on a scale

Primary: Efficacy: Change in Patient-reported Tinnitus Loudness Questionnaire (TLQ) Improvement From Baseline to Follow up Visit 3 (FUV3) — 0.80; 0.63 units on a scale — p=0.32

Primary: Mean Change in TFI Score From Baseline to Week 6 — -20.50 score on a scale

Primary: Change in Tinnitus Questionnaire (TQ) From Baseline to 3, 6, 12, and 18 Months — -17.8; -15.4; -11.5; -22.0 units on a scale — p=0.47

Primary: Tinnitus Functional Index (TFI) - Measure of Tinnitus Distress — 54.04; 53.93; 29.44; 47.35 score on a scale

Primary: Adverse Events — 0 participants

Primary: Number of Participants With Changes in Blood Oxygen Level as Measured by Functional Connectivity MRI — 18 participants — p=<0.01

Primary: GABA and Glutamate (Glx) Levels in the Auditory Cortex Derived From 3T Magnetic Resonance Spectroscopy — 2.11; 2.12; 2.09; 2.03 Ratio — p=0.05

Primary: Tinnitus Functional Index (TFI) — -12.1; -12.4; -6.0 scores on a scale

Primary: Tinnitus Questionnaire (TQ) — 34.3; 35.1 score on a scale

Primary: Change From Baseline in Tinnitus Reaction on the Tinnitus Handicap Questionnaire Scores (0-100) at 4 Months — 22.03; 24.9; 23.7; 25.4 units on a scale — p=>0.05

Primary: Tinnitus Functional Index (TFI); Measure of Tinnitus Distress — 61.06; 41.78; 40.38 score on a scale

Primary: Coping — 34.3; 31.6; 33.2; 30.0 units on a scale

Primary: Tinnitus Functional Index — 69.9; 68.2; 47.8; 66.8 units on a scale — p=<.0001