Clinical Trial Search

Primary: Audiometry - Pure Tone Average Done Over 1000, 2000 and 4000 Hertz (HZ) — -0.3; 0.71; -0.8; 0.3 decibels

Primary: Brain Speed Test — -0.09 z-score

Primary: Change in TFI (Tinnitus Functional Index) After Treatment or Sham Compared to Baseline — -10.08; -5.40; 0.95; -4.34 units on a scale — p=<0.05

Primary: Tinnitus Functional Index — 57.7; 39.6 score on a scale

Primary: Change in Objective Tinnitus Loudness — -6.1; -9.5; -10.2; -11.0 decibels sensation level (dB SL)

Primary: Number of Participants With Changes in Blood Oxygen Level as Measured by Functional Connectivity MRI — 18 participants — p=<0.01

Primary: Tinnitus Questionnaire (TQ, Goebel and Hiller 1998) Total Score Change From Baseline to End of Treatment — 13.6; 3.7 absolute TF-score change

Primary: Change in Short Term Relief of Tinnitus as Measured by the Tinnitus Handicap Inventory — -31 score on a scale

Primary: Average Change (Baseline-End of Treatment) Tinnitus Handicap Inventory (THI) — 10.7 units on a scale

Primary: Change From Baseline on the Analogue Rating of Tinnitus Awareness. — -4.08; -4.70; -9.82; -9.89 units on a scale — p=.04

Primary: Percentage of Tinnitus Functional Index (TFI) Responders at Weeks 4 and at Week 8 — 20; 27 Participants — p==0.385

Primary: Tinnitus Functional Index Change — 53.31; 44.10; 64.93 units on a scale

Primary: Change in PET Asymmetry Index — 1.2 ratio

Primary: Number of Participants With Treatment-Emergent Adverse Events (TEAE) — 1 Participants

Primary: Tinnitus Functional Index (TFI); Measure of Tinnitus Distress — 48.7; 50.52; 32.13; 28.95 score on a scale

Primary: Tinnitus Functional Index (TFI) - Measure of Tinnitus Distress — 54.04; 53.93; 29.44; 47.35 score on a scale

Primary: Tinnitus Questionnaire (TQ) — 34.3; 35.1 score on a scale

Primary: Tinnitus Handicap Inventory (THI) — 37.9; 45.1; 42.67; 26.0 units on a scale of 0-100 — p=<0.05

Primary: Efficacy: Change in Patient-reported Tinnitus Loudness Questionnaire (TLQ) Improvement From Baseline to Follow up Visit 3 (FUV3) — 0.80; 0.63 units on a scale — p=0.32

Primary: Mean Change in TFI Score From Baseline to Week 6 — -20.50 score on a scale

Primary: Tinnitus Functional Index Evaluation (TFI) — 35.6; 32; 44.8; 36.2 units on a scale

Primary: Change in Tinnitus Functional Index (TFI) Score — -1.8; -2.5 score on a scale

Primary: Tinnitus Functional Index (TFI); Measure of Tinnitus Distress — 61.06; 41.78; 40.38 score on a scale

Primary: GABA and Glutamate (Glx) Levels in the Auditory Cortex Derived From 3T Magnetic Resonance Spectroscopy — 2.11; 2.12; 2.09; 2.03 Ratio — p=0.05

Primary: Coping — 34.3; 31.6; 33.2; 30.0 units on a scale

Primary: Tinnitus Distress Rating — 5.71; 5.82; 5.36; 5.46 units on a scale

Primary: Change in Visual Analogue Scale (VAS) Score — 6.3; 6.3; 5.5; 5.2 score on a scale

Primary: Change in Tinnitus Functional Index (TFI) Score — -13.8; -2.9 units on TFI scale; change from baseline

Primary: Resting-State Functional MRI — 0.55; 0.35; 0.29; 0.59 Z-Score — p=0.01

Primary: Brain Speed Test — -0.28 units on a scale