Phase 2 N=41 Tolerance Following Peanut Oral Immunotherapy
Peanut Allergy
Primary: Tolerance, Partial Tolerance, or Treatment Failure — 5; 0; 8; 0 Participants
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=267 Examining Tolerance to CNS Stimulants in ADHD
Attention-deficit/Hyperactivity Disorder
Primary: Number of Dose Changes Required Per Protocol — 1.79; 1.61 Number of Increases
Phase 2 N=100 Evaluation of Donor Specific Immune Senescence and Exhaustion as Biomarkers of Tolerance Post Liver Transplantation
Liver Transplant · Liver Transplantation
Primary: The Percent of Participants Who Achieve Operational Tolerance 52 Weeks After Completion of Immunosuppression Withdrawal. — 16.4 Percent of Participants
Phase 1 N=34 Tolerability, Pharmacokinetics and Pharmacodynamics of BIA 9-1067
Parkinson's Disease (PD)
Primary: Number of Patients With at Least One Adverse Event — 3; 1; 1; 2 Number of patients
Phase 1 N=200 Oral Tolerability Of Two Nicotine Dosage Forms
Healthy Volunteer Smokers
Primary: Percentage of Participants With Oral Soft Tissue Related Adverse Events at Week 1 — 2.3; 12.6 Percentage
Phase 2 N=170 Study of Milk Allergy and Tolerance in Children
Food Hypersensitivity · Milk Hypersensitivity
Primary: Number of Participants With a Positive Progression in Tolerance of Baked Milk and Ultimately Unheated Milk in Dose Escalation Sub-arm Compared to Maintenance Sub-arm…
Phase 2 N=9 Establish Tolerance In MS With Peptide-Coupled, Peripheral Blood Mononuclear Cells
Multiple Sclerosis, Relapsing-Remitting
Primary: Number of Participants With Adverse Events as a Measure of Safety and Tolerability
N/A N=30 Tolerability of Acthar for the Treatment of Multiple Sclerosis in Relapses (TAMS)
Relapsing Remitting Multiple Sclerosis
Primary: ARMS (Assessing Relapses in Multiple Sclerosis) ADL Scores (Activities of Daily Living) — 3.1; 4.9 score on a scale — p=0.003
Phase 2 N=20 Time-limited Specific Oral Tolerance Induction in Children With Severe Egg Allergy
- Egg Hypersensitivity
Primary: Number of Children That Achieved Total (40 ml) or Partial (Less Than 40 ml But at Least 10 ml) Tolerance to Raw Egg — 9; 0 participants