Phase 2 N=57 Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations
Tympanic Membrane Perforation
Primary: Number of Patients With Tympanic Membrane Closure Following Treatment — 23; 10 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=25 Tympanoseal (Tympanic Membrane Device) Clinical Study
Tympanic Membrane Perforation
Primary: Number of Serious Adverse Events — 0 Serious Adverse Event
Phase 3 N=53 Evaluation of the Tympanostomy Tube Delivery System
Otitis Media With Effusion · Acute Otitis Media
Primary: Safety of Tympanostomy Tube (TT) Delivery System — 0.0 percentage of ears
N/A N=250 Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media
Acute Otitis Media
Primary: The Rate of Occurrence of Acute Otitis Media (AOM) Episodes Per Child-Year — 1.48; 1.56 Occurrences per child-year — p=0.66
N/A N=16 Clinical Study of the Tympanostomy Tube Delivery System
Otitis Media With Effusion
Primary: Device Success — 21 devices
N/A N=25 Singapore Tympanostomy Tube Delivery System Study
Otitis Media
Primary: Percentage of Ears Treated Successfully With the TTDS in the Absence of Acute Intraprocedural Adverse Events. — 94.6 percentage of ears
N/A N=70 Tympanostomy Tube Placement in Children in the Office (Inova Study)
Otitis Media
Primary: Number of Participants With Procedural, Serious, and Device-Related Adverse Events — 0 participants
Phase 3 N=370 In-Office Tympanostomy Tube Placement in Children (OTTER)
OME - Otitis Media With Effusion · AOM - Acute Otitis Media
Primary: Procedural Success: — 103; 91 Participants
N/A N=109 Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus
Acute Otitis Media · Chronic Otitis Media · Recurrent Acute Otitis Media
Primary: Proportion of Subjects Who Achieved Anesthesia Effectiveness Per Investigator Assessment — 89.9 percentage of subjects
N/A N=109 Study of the Hummingbird TTS™ Tympanostomy Tube System
Otitis Media
Primary: Percentage of Procedures Converted From Sedation to General Anesthesia — 12.8 percentage of procedures converted
N/A N=22 Cochlear Promontory Stimulation for Treatment of Tinnitus
Tinnitus
Primary: Change in Short Term Relief of Tinnitus as Measured by the Tinnitus Handicap Inventory — -31 score on a scale
N/A N=24 Efficacy of Platelet- and Extracellular Vesicle-rich Plasma in Chronic Postsurgical Temporal Bone Inflammations
Otitis Media Chronic · Temporal Bone
Primary: Change in Inflammation Surface Area. — 100; 100; 43; 135 percentage of the baseline surface
Phase 2 N=40 Study to Compare Active Tymbion Iontophoresis to Sham Tymbion Iontophoresis for Anesthesia of the Tympanic Membrane
Healthy Volunteer
Primary: Subject-reported Visual Analog Scale (VAS) Pain Score Following Tympanic Membrane Tap for Subjects Treated With Active Tymbion Iontophoresis Compared to VAS Score for…
Phase 3 N=385 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT)
Otitis Media With Effusion in Children · Otitis Media Recurrent
Primary: Percentage of Subjects With Sustained Clinical Cure at Day 8 — 76.2; 71.8; 56.8 percentage of participants
N/A N=101 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media
Chronic Otitis Media
Primary: Number of Participants With Otomicroscopic Signs of Otorrhea in Either Ear — 13; 27; 15; 23 participants
Phase 3 N=501 Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes
Otitis Media
Primary: Number of Subjects With Post-surgical Otorrhea — 383; 118 Participants
Phase 3 N=33 Open-Label Study of OTO-201 for Middle Ear Effusion Evaluating Trans-Tympanostomy Tube Administration
Bilateral Middle Ear Effusion
Primary: Otoscopic Examination: Auricle and Meatus — 1 ears
N/A N=69 Retrospective Health Care Utilisation and Current Quality of Life in Adults With Chronic Otitis Media Who Had a Middle Ear Surgery
Chronic Otitis Media
Primary: Number and Type of Contacts With Health Care Providers — 45; 14; 5; 3 Participants
N/A N=29 Acclarent Tympanostomy Tube Delivery System for the Treatment of Patients Requiring Tympanostomy Tube Insertion
Otitis Media
Primary: Ear Outcome Success — 21 ears
Phase 3 N=356 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2
Otitis Media With Effusion in Children · Otitis Media Recurrent
Primary: Percentage of Subjects With Sustained Clinical Cure at Day 8 — 77.1; 75.5; 65.3 percentage of participants
N/A N=205 Telephone Tinnitus Education for Patients With Traumatic Brain Injury (TBI)
Tinnitus
Primary: Tinnitus Functional Index — 69.9; 68.2; 47.8; 66.8 units on a scale — p=<.0001
Phase 3 N=266 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement
Otitis Media With Effusion
Primary: Percentage of Participants Who Were Treatment Failures — 24.6; 44.8 percentage of treatment failures
Phase 3 N=266 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement
Otitis Media With Effusion
Primary: Percentage of Participants Who Were Treatment Failures. — 21.3; 45.5 percentage of treatment failures
N/A N=39 Evaluation of a New mHealth Tympanometer
Hearing Loss
Primary: Classification Agreement Between Prototype mHealth Tympanometer and Commercial Tympanometer — 93.33 Percent Agreement
N/A N=199 Hummingbird TTS Ear Tube Delivery Study
Otitis Media
Primary: Percentage of Ears in Which an Ear Tube Was Successfully Delivered Across the Tympanic Membrane — 393 Ears
N/A N=16 Eustachian Tube Dysfunction Assessment
Eustachian Tube Dysfunction
Primary: Latency Between mLVP and mTVP Signals — 127.26 Time in milliseconds
N/A N=39 A Novel Approach for Thyroplasty Type 1, With Prolene Mesh. A Prospective Study.
Vocal Cord Paralysis · Phonasthenia · Presbylarynges
Primary: Change in Mean Phonation Time — 7.74; 14.08 seconds
Phase 3 N=10 Intratympanic Steroid for Bell's Palsy
Bell's Palsy · Facial Nerve Paresis
Primary: Facial Nerve Recovery — 7; 81.56 Days
N/A N=30 Investigations of Ear Tip Performance, Perceptions, and Experiences
Hearing Aids
Primary: Real Ear Measures — 61.23; 60.23; 60.5; 64.53 dB SPL — p=<0.05
Phase 2 N=30 Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT)
Barotrauma;Ear · OME - Otitis Media With Effusion · AOM - Acute Otitis Media
Primary: Subject-reported Pain Score Following Tube Delivery System (TDS) Tube Placement Using the Visual Analogue Scale (VAS) by Subject Compared to a Performance Goal. — 9.4…