N/A N=25 Exploratory Study on Effect of Whitening Agent With Emulsion Gel in Xerostomic Population
Xerostomia
Primary: Subjective Perception of Mouth Dryness — 6.92; 6.46; 4.21; 3.46 units on a scale — p=.45
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=39 Clinical Evaluation of Oral Rinse for Xerostomia
Xerostomia
Primary: Change in Dry Mouth Symptom by Visual Analog Scale at 14 Days From Baseline — 10.1; 11.6; 13.0 mm
Phase 3 N=185 Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity
Xerostomia · Depression · Hypertension
Primary: Dry Mouth Questionnaire (DMQ) — 3.4; 1.4 units on a scale
N/A N=129 Blinded Dry Mouth Spray Crossover Study
Xerostomia · Head and Neck Cancer · Xerostomia Following Radiotherapy
Primary: Oral Dryness — 45.5; 46.6; 52.76; 54.1 units on a scale — p=<0.501
N/A N=31 NeutraSal Treatment for Xerostomia in OSAS Patients Using CPAP Therapy
Xerostomia
Primary: Change in Percentage of Time With CPAP (Continuous Positive Airway Pressure) Usage — -5.09; 11.67 percentage of time
N/A N=42 Clinical Evaluation of MucoPEG™ for Xerostomia
Dry Mouth · Xerostomia
Primary: Change in VAS for Mouth Dryness — -0.8; -0.7; -1.5; -0.4 score on a scale — p=<0.01
Phase 4 N=100 Effect of Korean Red Ginseng (KRG) on Dry Mouth
Xerostomia
Primary: Visual Analogue Scale of Subjective Dry Mouth — 5.21; 5.03 cm — p=<0.05
N/A N=137 Improvement of Dry Mouth Sufferers After Using an Experimental Dry Mouth Rinse Compared to a Water Control
Dry Mouth
Primary: Response to "Relieving the Discomfort of Dry Mouth" From the Modified PPAQ I 4- and 6-hours Post-use on Day 1 of Treatment — 2.51; 3.26; 3.43 score on a scale
N/A N=16 Effects of an External Oral Irrigation Device on Patients With Dry Mouth
Xerostomia
Primary: Change in Oral Health Related Quality of Life (OHRQoL) — 10.2 score on a scale
N/A N=100 Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms
Xerostomia
Primary: Mean Response to the Question 1 'Relieving the Discomfort of Dry Mouth' in Product Performance and Attributes Questionnaire 3 (PPAQ3) at 120 Minutes(Mins) Post Treatment…
N/A N=66 Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
KERATOCONJUNCTIVITIS SICCA · XEROSTOMIA · SICCA SYNDROME
Primary: The Xerostomia Inventory — 40.2; 39.3 units on a scale — p=0.05
Phase 2 N=60 Green Tea Lozenges for the Management of Dry Mouth
Xerostomia · Sjogren Syndrome · Dry Mouth
Primary: Change in Salivary Flow From Baseline — 0.17; 0.10; 0.66; 0.04 ml/min
N/A N=15 Efficacy of Cevimeline Versus Pilocarpine in the Secretion of Saliva
Dry Mouth
Primary: Change From Baseline in Saliva Production in ml. — 1.41; 3.93; 5.31; 10.34 ml — p=0.05
Phase 2 N=49 Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer
Head and Neck Cancer · Radiation Toxicity · Xerostomia
Primary: Number of Patients Scored as Having the Surgical Technique of Submandibular Salivary Gland Transfer Performed "Per Protocol" — 34 participants
N/A N=258 Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer
Radiation-Induced Xerostomia · Head and Neck Cancer · Radiation Toxicity
Primary: Xerostomia Questionnaire Scores — 57.3; 50.6; 55.0; 55.2 score on a scale 0-80 — p=0.0167
N/A N=55 Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects
Xerostomia
Primary: Number of Participants With Response to Post-Product Use Questionnaires 1 (PPUQ 1); Question No.1 — 1; 1; 5; 0 Participants
Phase 2 N=30 Mesenchymal Stemcells for Radiation Induced Xerostomia
Xerostomia
Primary: Number of Participants With Adverse Events as a Measure of Safety — 0; 0 participants
Phase 1 N=20 Fluoride Retention in the Mouth of Older Adults
Hyposalivation
Primary: Fluoride Concentration in Dental Biofilm Fluid at Baseline — 0.24; 0.22 parts per million (ppm) of fluoride — p=0.8412
N/A N=40 Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray
Xerostomia
Primary: 10 cm Mouth Dryness Visual Analog Score — 4.51; 4.6 cm
N/A N=396 A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water
Xerostomia
Primary: Modified Product Performance and Attributes Questionnaire I (PPAQ I) (Question Number 1: Relieving the Discomfort of Dry Mouth) — 2.7; 2.9; 2.6; 2.0 Score on scale…
N/A N=53 Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Edentulous Jaw · Edentulous Mouth
Primary: Change From Baseline in Patient Comfort for as Assessed by Numerical Scale. — 0.99; 1.16 units on a scale
Phase 3 N=196 Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer
Head and Neck Cancer · Xerostomia
Primary: Phase II: Treatment Compliance (Number of Compliant Patients) — 12; 44 Participants
Phase 2 N=104 Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome
Xerostomia · Sjogren's Syndrome
Primary: Overall Improvement Rate in Dry Mouth Symptoms — 26.0; 20.0; 44.0; 27.1 percentage of participants
N/A N=22 A Pilot Study to Assess Dry Mouth Relief After Using an Experimental Mouth Rinse
Dry Mouth
Primary: Product Performance and Attributes (PPAQ I) Question #1: 2-hr at Day 4 — 1.79; 2.97; 3.33 units on a scale
N/A N=60 Trial of Parotid Sparing Whole Brain Radiation
Xerostomia
Primary: Xerostomia One Month After Completion of Treatment — 5; 7; 1; 6 Participants
Phase 2 N=10 Incobotulinum Toxin A (Xeomin®) for Troublesome Sialorrhea in Parkinson's Disease (PD)/Parkinsonism
Sialorrhea
Primary: Objectively Measured Salivary Weight — -0.07; -0.68 gm
N/A N=76 Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer
Dysphagia · Pain · Stage I Oropharyngeal Squamous Cell Carcinoma
Primary: Pain Visual Analogue Scale (VAS) Score Measured at 10-point Scale — 7.4; 6.8; 6.0; 6.4 units on a scale — p=0.25
N/A N=29 Duration of Effect of Biotene Spray in Patients With Dry Mouth
Dry Mouth
Primary: Mean Duration of Action of Intervention — 27; 26 minutes
N/A N=11 Does Craniosacraltherapy Combined With Exercises That Focuses om Respiration and Posture in the Upper Body Have an Effect on Xerostomia and Other Late Sequelae on People Who Has Been Suffering From Cancer in Mouth and Throat?
Xerostomia Following Radiotherapy · Xerostomia Following in Neck or Head After Cancer Surgery · Other Late Sequelae Following Radiotherapy and Cancer Surgery in Neck or Head
Primary: Xerostomia Questionnaire — 8; 46.4 score on a scale
Phase 2 N=68 Radiation Therapy With or Without Chemotherapy in Reducing Mouth Dryness in Patients With Nasopharyngeal Cancer
Head and Neck Cancer · Oral Complications of Radiation Therapy · Radiation Toxicity
Primary: Protocol Compliance of Intensity-modulated Radiotherapy Treatment Delivered — 9 participants