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One-stage RIRS for renal stones shows longer operative time after prior PCNL in retrospective cohortDoes past kidney stone surgery affect your next one?

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Key Takeaway
Consider longer operative time for RIRS after prior PCNL, but note observational limitations.

This retrospective cohort study included 115 patients with renal stones who underwent one-stage retrograde intrarenal surgery (RIRS). The population was divided into three groups based on surgical history: Group A (28 cases with prior percutaneous nephrolithotomy [PCNL]), Group B (37 cases with prior RIRS), and Group C (50 cases with no history of urinary stone surgery). The comparator was these historical groups, with follow-up at 4 weeks postoperatively.

Main results showed that operative time was significantly longer in Group A (61.5 ± 8.9 minutes) compared to Group B (53.4 ± 6.3 minutes) and Group C (51.0 ± 6.7 minutes), with P < 0.01. For other outcomes, no significant differences were found: postoperative hospital stay was 2.2 ± 0.8 days in Group A, 2.2 ± 0.7 days in Group B, and 2.1 ± 0.3 days in Group C (P > 0.05); postoperative increase in serum creatinine levels was 12.23 ± 8.68 μmol/L in Group A, 13.34 ± 9.11 μmol/L in Group B, and 12.16 ± 8.38 μmol/L in Group C (P > 0.05); complication rates were 7.1% (2/28) in Group A, 8.1% (3/37) in Group B, and 8.0% (4/50) in Group C (P > 0.05); stone-free rates at 1 week were 64.2% (18/28) in Group A, 62.2% (23/37) in Group B, and 66.0% (33/50) in Group C (P > 0.05); and at 4 weeks were 85.7% (24/28) in Group A, 89.2% (33/37) in Group B, and 90.0% (45/50) in Group C (P > 0.05).

Safety and tolerability data indicated that all patients successfully completed surgery, with complication rates low and similar across groups; serious adverse events and discontinuations were not reported. Key limitations include the retrospective study design, which may introduce bias, and lack of reporting on long-term outcomes beyond 4 weeks, primary outcome, setting, funding, or conflicts. Practice relevance is restrained: for patients with renal stones who have previously undergone PCNL or RIRS, one-stage RIRS may be an effective and safe option, but the association-only nature of this observational study precludes causal conclusions.

When you're facing another kidney stone surgery, it's natural to worry about how your past procedures might impact this one. A recent study dug into this by looking back at 115 patients who underwent a one-stage retrograde intrarenal surgery (RIRS) for kidney stones. The patients were grouped based on their surgical history: some had a previous percutaneous nephrolithotomy (PCNL), others had a prior RIRS, and some had no history of urinary stone surgery.

The key finding was that patients with a history of PCNL had significantly longer operative times—about 61.5 minutes on average, compared to around 53-51 minutes for the other groups. However, when it came to other important measures, there were no big differences. Hospital stays, increases in serum creatinine (a marker of kidney function), complication rates, and stone-free rates at one and four weeks were all similar across the groups. Complication rates hovered around 7-8%, and by four weeks, about 85-90% of patients were stone-free.

It's important to note that this was a retrospective study, meaning it looked back at existing data rather than randomly assigning patients to groups. This limits how strongly we can say the past surgery caused the longer operation times. Also, the study only followed patients for four weeks, so we don't know about long-term outcomes. While the results are reassuring for many, they come from a specific group of 115 patients, so they might not apply to everyone with kidney stones.

What this means for you:
Past PCNL surgery may mean longer operation time, but other outcomes are similar.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
PurposeTo investigate the influence of a history of percutaneous nephrolithotomy (PCNL) and a history of retrograde intrarenal surgery (RIRS) on the efficacy and safety of one-stage RIRS in patients with renal stones.MethodsA retrospective analysis was conducted on the clinical data of 115 patients with renal stones who underwent one-stage RIRS from January 2022 to June 2025. These patients were divided into three groups: group A (with a history of PCNL) comprising 28 cases, group B (with a history of RIRS) comprising 37 cases, and group C (without a history of urinary stone surgery) comprising 50 cases. The operative time, postoperative hospital stay, postoperative increase in serum creatinine levels, complication rate, and stone-free rate (SFR) at 1 week and 4 weeks postoperatively were compared among the three groups. Linear regression was employed to identify independent predictors of operative time, while logistic regression was used to analyze independent factors influencing the stone-free rate at 4 weeks postoperatively and the occurrence of complications.ResultsAll patients in the three groups successfully completed the surgery. The operative time in group A was (61.5 ± 8.9) min, which was significantly longer than that in group B [(53.4 ± 6.3) min] and group C [(51.0 ± 6.7) min] (P < 0.01). There were no significant differences in the postoperative hospital stay among group A [(2.2 ± 0.8) d], group B [(2.2 ± 0.7) d], and group C [(2.1 ± 0.3) d] (P>0.05). No significant differences were observed in the postoperative increase in serum creatinine levels among group A [(12.23 ± 8.68) μmol/L], Group B [(13.34 ± 9.11) μmol/L], and group C [(12.16 ± 8.38) μmol/L] (P > 0.05). The complication rate was 7.1% in group A, with no significant differences compared to 8.1% in group B and 8.0% in group C (P > 0.05). At 1 week postoperatively, the SFR was 64.2% in group A, with no significant differences compared to 62.2% in group B and 66.0% in group C (P>0.05); at 4 weeks postoperatively, the SFR was 85.7% in group A, with no significant differences compared to 89.2% in group B and 90.0% in group C (P >0.05). Multivariate logistic regression analysis demonstrated that a history of urinary stone surgery was not an independent influencing factor for the SFR at 4 weeks postoperatively or the occurrence of complications (P>0.05).ConclusionA history of PCNL may prolong the operative time of one-stage RIRS, but it has no significant impact on the SFR or complication rate. A history of RIRS has no significant effect on the operative time, stone-free rate, or postoperative complication rate of one-stage RIRS. For patients with renal stones who have previously undergone PCNL or RIRS, one-stage RIRS represents an effective and safe treatment option.
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