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Asthma and COPD are associated with significantly increased risk of pertussis infectionAsthma and COPD Patients Face Higher Risk of Pertussis Infection

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Key Takeaway
Note that patients with asthma and COPD have a significantly higher risk of pertussis infection.

This meta-analysis synthesized data from 10 studies, including 7 cohort and 3 case-control studies, involving over 18.6 million participants to evaluate the risk of pertussis in patients with asthma and chronic obstructive pulmonary disease (COPD). The analysis found that patients with asthma have an increased risk of pertussis infection, with an OR of 2.29 (95% CI 1.94-2.69) and a RR of 3.36 (95% CI 2.77-4.08). Similarly, patients with COPD showed an increased risk of pertussis infection with an OR of 2.00 (95% CI 1.53-2.62).

The authors noted that while results were robust according to leave-one-out sensitivity analyses, the underlying data come from observational studies rather than randomized trials. This means a direct causal link between these respiratory conditions and pertussis risk cannot be established from this evidence alone.

Clinicians may consider these findings when managing vaccination protocols for patients with chronic respiratory conditions. Strengthening clinical identification and vaccination management could help reduce preventable infections in these populations. However, the inconsistent prior findings noted by the authors suggest that while the association is statistically significant, it should be integrated into practice with an understanding of the observational nature of the evidence.

How this fits prior evidence

This meta-analysis addresses a gap regarding the risk of pertussis in patients with chronic respiratory conditions. It builds upon existing knowledge of asthma and COPD as inflammatory disorders, such as those influenced by the CXCL16/CXCR6 axis. While previous coverage focused on factors influencing the development or management of asthma and COPD, this finding specifically quantifies the increased risk of pertussis infection for these patient populations.

A large review of data from over 18.6 million people looked at the link between chronic lung conditions and pertussis, also known as whooping cough. The study specifically focused on patients with asthma and chronic obstructive pulmonary disease (COPD) to see if they were more likely to catch the infection.

The findings showed that both groups had a higher risk of pertussis. For those with asthma, the risk was notably higher than for others. People with COPD also showed an increased risk of infection. These results were consistent across several different types of studies included in the analysis.

Because these results are based on observational data, they show a link rather than a direct cause. The study suggests that doctors and health officials should focus more on identifying at-risk patients and managing vaccinations to prevent infections. Talk with your healthcare provider about how these findings might affect your specific care plan.

What this means for you:
People with asthma or COPD may have an increased risk of pertussis infection based on large-scale data.

Common questions

Does having asthma increase the risk of pertussis?

Yes, the data indicates an increased risk of pertussis for patients with asthma. The analysis showed an odds ratio of 2.29 and a relative risk of 3.36 for these individuals. Because this is based on observational studies, it shows a link between the two conditions rather than a direct cause.

Is there a higher risk of pertussis for people with COPD?

The study found that patients with chronic obstructive pulmonary disease (COPD) also have an increased risk of pertussis infection. The results showed an odds ratio of 2.00 for this group. These findings suggest that people with these lung conditions may need extra focus on prevention.

How much data was used to reach these conclusions?

The findings are based on a large meta-analysis involving more than 18.6 million participants across 10 different studies. This included both cohort and case-control studies, providing a broad look at the relationship between chronic lung conditions and pertussis risk.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJan 2026
View Original Abstract ↓
BACKGROUND: Pertussis, caused by Bordetella pertussis, has resurged globally despite widespread childhood vaccination. With waning immunity, adolescent and adult cases have increased. Patients with asthma and chronic obstructive pulmonary disease (COPD) may be more susceptible due to chronic airway inflammation and impaired immune function, but prior findings are inconsistent. This study aims to systematically evaluate the association between asthma and COPD with the risk of pertussis infection through a meta-analysis. METHODS: PubMed, Cochrane Library, Embase, Web of Science, CBM, CNKI, VIP, and Wanfang were searched from inception to August 7, 2025. Observational studies reporting adjusted effect measures (OR, RR, HR, IRR) were included. Study quality was assessed using the Newcastle-Ottawa Scale. Random-effects meta-analyses (DerSimonian-Laird) were performed when ≥3 studies reported comparable measures; otherwise, results were synthesized descriptively. PROSPERO: CRD420251109793. RESULTS: Ten studies (7 cohort, 3 case-control) including >18.6 million participants were analyzed. Asthma was associated with increased pertussis risk (pooled OR = 2.29, 95% CI 1.94-2.69; I = 89%), and COPD showed a similar association (pooled OR = 2.00, 95% CI 1.53-2.62; I = 94%). A supplementary RR-based analysis supported the asthma association (pooled RR = 3.36, 95% CI 2.77-4.08). Leave-one-out sensitivity analyses indicated robust results. CONCLUSION: Evidence from existing observational studies suggests that asthma and chronic obstructive pulmonary disease (COPD) are associated with an increased risk of pertussis infection. The findings indicate that clinical identification and vaccination management should be strengthened to reduce preventable infections and the public health burden.
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