Medical Editor
Dr. Amelia Tan, PhD
Internal Medicine & Chronic Disease — Organ-system RCTs, biomarker endpoints, immune-mediated disease, biologics.
Dr. Amelia Tan is a freelance medical writer based in Singapore with over 10+ years of experience in clinical research, regulatory writing, and pharmaceutical communications, specializing in Internal Medicine & Chronic Disease. She holds a PhD in Biomedical Sciences from the National University of Singapore and a Master's degree in Clinical Research from Nanyang Technological University. She also holds certification in Good Clinical Practice (ICH-GCP) and regulatory writing standards.
Amelia's expertise spans organ-system clinical trials and biologic therapies, with a focus on cardiology, endocrinology, nephrology, pulmonology, gastroenterology, hematology, rheumatology, and immune-mediated diseases. She has extensive experience working with randomized controlled trials involving biomarker endpoints and chronic disease progression models.
Prior to transitioning into freelance writing, Amelia worked as a Clinical Research Scientist at a global pharmaceutical company, where she led multi-center trials across Southeast Asia. She is known for her ability to translate complex clinical datasets into clear, compliant, and publication-ready scientific content for regulatory authorities, clinicians, and research teams.
Articles in this group — last 14 days
IV-PEG asparaginase compared to IM-EC in children with acute lymphoblastic leukemia
PEG-asparaginase shows lower toxicity in childhood leukemia trial
This Phase 3 randomized controlled trial evaluated intravenous PEG-asparaginase (IV-PEG) versus intramuscular native E. coli L-asparaginase …
A new trial finds that PEG-asparaginase may cause fewer side effects than standard treatment for children with leukemia.
Digital multi-domain intervention aims to prevent disability in older adults
New trial plans to use digital tools for senior mobility
This study protocol describes a randomized controlled trial of a digital platform-based, multi-domain intervention for community-dwelling ad…
A new trial will test if a digital platform can help older adults maintain their physical strength and prevent disability.
R-(+)-propranolol targets SOX18 for anti-hemangioma effect independent of beta-blockade
New insights into how specific medicine types treat infant hemangioma growth
This systematic review examines the mechanism of R-(+)-propranolol in infantile hemangioma. It identifies SOX18 as the core molecular target…
A new review shows that one specific form of propranolol may target and shrink baby hemangiomas through a unique pathway.
Academic partnerships for family medicine education promote contextually grounded curricula and faculty development pathways
Academic partnerships help shape global primary health care education
This narrative review evaluates the global landscape of academic partnerships for family medicine and primary health care education. It iden…
New research shows how international academic partnerships create better training for family doctors and community health workers around the…
Hydrogen sulfide mediates bacterial antibiotic tolerance through iron chelation, efflux pump activation, and metabolic dormancy
Hydrogen Sulfide May Help Overcome Bacterial Antibiotic Tolerance
This systematic review synthesizes the role of hydrogen sulfide (H2S) in mediating multidrug tolerance in bacteria. The authors identify thr…
New research identifies how hydrogen sulfide helps bacteria resist antibiotics, offering a potential new way to target and eliminate persist…
Bortezomib, cyclophosphamide, and dexamethasone achieved remission in a patient with AL amyloidosis and POEMS syndrome
Treatment shows success for heart failure and rare blood diseases
This case report and literature review describes the treatment of an elderly male with concurrent AL amyloidosis and POEMS syndrome. The pat…
A new look at a complex case reveals how a specific drug combination helped an elderly man with multiple rare conditions.
Current molecular and cellular phenotypes do not yet support clinical subtype identification for recurrent pregnancy loss
New research looks at why some pregnancies end early
This mini review examines maternal-fetal interface abnormalities in patients with unexplained recurrent pregnancy loss (URPL). The authors c…
Doctors are looking for better ways to understand and treat the reasons behind repeated pregnancy loss.
TNF inhibitors may be effective for juvenile idiopathic arthritis in patients with DiGeorge syndrome
Biologic treatments show promise for children with DiGeorge syndrome
This case report and literature review examines the management of juvenile idiopathic arthritis (JIA) in children with DiGeorge syndrome (DG…
Children with both DiGeorge syndrome and juvenile idiopathic arthritis may find relief from joint pain using specific biologic medications.
mHealth apps reduce HbA1c by 0.39% in type 2 diabetes across 19 RCTs
Mobile Health Apps Help Manage Blood Sugar in Type 2 Diabetes
This meta-analysis of 19 RCTs with 2,166 participants found that mobile health (mHealth) app interventions significantly reduced HbA1c (MD -…
Using mobile health applications can help people with type 2 diabetes lower their blood sugar levels and improve their overall quality of li…
Oral-health promotion improves outcomes for adults with type 2 diabetes when guidance is provided
Oral health care is often missed in type 2 diabetes management
This scoping review of 9 peer-reviewed studies examines oral-health promotion and prevention in adults with type 2 diabetes. The authors fin…
Many people with type 2 diabetes do not know their oral health is at risk, and doctors often provide inconsistent guidance on how to manage …
Prediabetes linked to 2.78-fold higher odds of obstructive sleep apnea in meta-analysis
Prediabetes Linked to Higher Risk of Obstructive Sleep Apnea
A meta-analysis of 8 cross-sectional studies (18,040 participants) found that prediabetes is associated with significantly higher prevalence…
A large review of data shows that people with prediabetes have a significantly higher risk of developing obstructive sleep apnea.
OSAS not significantly tied to diabetic retinopathy overall, but risk doubles in Asian subgroups
Sleep Apnea Link to Diabetic Retinopathy Varies by Region
This meta-analysis of 599,405 patients with type 2 diabetes found no significant overall association between obstructive sleep apnea syndrom…
New data suggests that the link between sleep apnea and eye damage in people with type 2 diabetes depends on location and testing methods.
Radiomics and deep learning provide promising tools for precise assessment of adrenal masses
AI and radiomics show promise for adrenal tumor diagnosis
This systematic review evaluates the utility of radiomics and deep learning (DL) techniques in assessing adrenal masses including pheochromo…
A new review finds AI-powered imaging analysis could improve how doctors diagnose adrenal masses, but clinical use is still far off.
Proposed pathway for systematic MASLD/MASH assessment in type 2 diabetes
New Pathway Proposed to Manage Liver Disease in Diabetes Patients
This narrative review proposes a structured, risk-adapted outpatient pathway for MASLD/MASH assessment in patients with type 2 diabetes, sta…
A new proposed management plan aims to help people with type 2 diabetes identify and assess liver conditions more systematically.
Higher Triglyceride-glucose index levels are associated with increased risk of Atrial Fibrillation
Higher Triglyceride-Glucose Index Linked to Increased Risk of Atrial Fibrillation
This meta-analysis of 25,376 individuals found significantly higher TyG index levels in patients with Atrial Fibrillation compared to those …
A high triglyceride-glucose index may serve as a potential marker for identifying people at risk for atrial fibrillation and related heart c…
Supraventricular tachyarrhythmias occur more frequently in patients with Arrhythmogenic Cardiomyopathy and Brugada Syndrome
Heart conditions like Brugada syndrome increase risk of rapid heartbeats
This systematic review of 30 studies indicates that supraventricular tachyarrhythmias (SVT) are more frequent in patients with Arrhythmogeni…
Patients with certain heart conditions face a higher risk of fast heartbeats, which can lead to complications like heart failure or unnecess…
Higher serum total bilirubin levels associated with lower long-term risk in coronary heart disease patients
High bilirubin levels linked to lower heart risk in some cases
This meta-analysis examined the association between serum total bilirubin and major adverse cardiovascular events in patients undergoing per…
New data suggests high bilirubin might protect patients with coronary heart disease from long-term risks, though the evidence is still early…
FDA Approves Dyna-hex 4 (chlorhexidine gluconate) for Healthcare Personnel Handwash
FDA approves Dyna-hex 4 for handwashing and skin cleansing.
The FDA approved Dyna-hex 4 (chlorhexidine gluconate) for healthcare personnel handwash, skin wound cleansing, and general skin cleansing. T…
The FDA approved Dyna-hex 4 (chlorhexidine gluconate) for use as a handwash and skin cleanser in healthcare settings. It helps reduce bacter…
Consistent monitoring principles exist for patients with familial Mediterranean fever across 42 publications
Review Shows Consistent Monitoring Principles for Familial Mediterranean Fever
This narrative review of 42 publications synthesizes monitoring principles and parameters for patients with familial Mediterranean fever. Th…
New guidance helps doctors create personalized monitoring plans for patients with familial Mediterranean fever to better manage inflammation…
FLASH radiotherapy transitions from experimental physics toward clinical precision and proton therapy workflows
Mapping the Growth and Future of FLASH Radiotherapy Research
This systematic review and bibliometric mapping analyzes 807 articles to map the global research landscape of FLASH-RT. The analysis identif…
Research shows a rapid surge in interest and development for FLASH radiotherapy as it moves from physics experiments toward clinical use.
Exercise programs improve muscle mass and physical performance indicators in patients with liver cirrhosis
Exercise improves muscle strength in cirrhosis patients
This meta-analysis of 16 studies involving 942 patients found that exercise interventions significantly improved 6-min walk distance, thigh …
Exercise boosts muscle mass and walking ability in people with cirrhosis and muscle loss, a new analysis finds.
Electroacupuncture ranks highest for total efficacy in acupuncture interventions for polycystic ovary syndrome
Acupuncture Methods Show Varying Success for Polycystic Ovary Syndrome
This network meta-analysis of 92 randomized controlled trials evaluated various acupuncture-based interventions for polycystic ovary syndrom…
Different types of acupuncture treatments show varying levels of success in managing hormones and testosterone for people with PCOS.
Sarcopenia linked to 2.16-fold higher odds of atrial fibrillation in meta-analysis
Muscle loss linked to higher risk of irregular heartbeats
A meta-analysis of over 3 million patients found sarcopenia associated with significantly higher odds of atrial fibrillation (OR 2.16; 95% C…
A large study involving over 3 million people found that muscle loss, known as sarcopenia, is linked to a higher risk of developing atrial f…
Organ transplantation impacts oral microbiome composition and bacteria associated with periodontal inflammation
Organ transplants may change bacteria causing gum inflammation
This narrative review examines how various organ transplant procedures influence the oral microbiome, specifically focusing on bacteria link…
New research looks at how organ transplant procedures impact the oral microbiome and the specific bacteria that cause gum disease.
Four specific miRNAs in extracellular vesicles satisfy high-tier causality for metabolic and inflammatory regulation
Extracellular Vesicles Show Potential for Managing Metabolic Health Conditions
This systematic review evaluates the role of extracellular vesicles (EVs) in managing obesity, type 2 diabetes, MASLD, and atherosclerosis. …
New research identifies specific molecules within extracellular vesicles that may play a role in managing obesity, diabetes, and liver disea…
Bismuth quadruple and concomitant regimens achieve >85% H. pylori eradication amid rising clarithromycin resistance
H. pylori treatments failing as resistance grows, review finds
This narrative review synthesizes current H. pylori eradication strategies, noting that clarithromycin resistance exceeds 15%-20% in most re…
Clarithromycin resistance now tops 15-20% in most regions, but bismuth quadruple and other combos still clear the bug over 85% of the time.
Metabolic surgery review outlines framework for T2DM and obesity management
Metabolic Surgery Review Aims to Guide Diabetes Care
This systematic review aims to provide a theoretical framework and practical insights for metabolic surgery in patients with type 2 diabetes…
A new review explores how metabolic surgery fits into type 2 diabetes and obesity treatment, focusing on techniques and outcomes.
Combination Immunotherapy Improves Outcomes for BCG Unresponsive Non Muscle Invasive Bladder Cancer
Combination immunotherapy shows promise for bladder cancer patients
Multi-agent immunotherapy regimens show superior response rates and progression-free survival compared to monotherapy in patients with NMIBC…
A new combination of immunotherapies may improve response rates and survival for patients with specific types of bladder cancer.
Financial toxicity and food insecurity create a health-economic pathway impacting nutrition in women with cancer
Financial stress and food insecurity impact health for women with cancer
This mini review explores the link between financial toxicity, food insecurity, and nutritional vulnerability in women with cancer. The auth…
High medical costs and lack of reliable food sources can lead to malnutrition and fatigue in women fighting breast and gynecologic cancers.
Lower baseline soluble PD-L1 levels correlate with improved progression-free and overall survival in NSCLC
Blood Marker May Predict Lung Cancer Outcomes
This meta-analysis of 1967 patients with non-small cell lung cancer (NSCLC) found that lower baseline sPD-L1 levels are associated with sign…
A protein in the blood called sPD-L1 may help predict how well lung cancer patients respond to treatment.
TKI plus chemotherapy achieves deep molecular remission in Ph+ leukemia case with diagnostic framework
One patient's leukemia remission offers clues for rare diagnosis
This systematic review with a case report describes a patient with Philadelphia chromosome-positive leukemia who achieved complete remission…
A patient with a rare leukemia achieved deep remission for 35 months. The case highlights how to tell apart two similar-looking blood cancer…
Protein acetylation serves as a critical regulatory hub for inflammation and metabolism in atherosclerosis
New Research Identifies Protein Acetylation as Key Link in Atherosclerosis
This systematic review examines protein acetylation as a link between epigenetic regulation and metabolic homeostasis in atherosclerosis. Th…
Scientists have identified protein acetylation as a critical hub for inflammation and metabolism, offering new paths for treating heart dise…
SGLT2 inhibitors and GLP-1 receptor agonists show similar MACE reduction in type 2 diabetes
Trial shows similar heart benefits for two diabetes medications
This systematic review and network meta-analysis compared SGLT2 inhibitors and GLP-1 receptor agonists for major adverse cardiovascular even…
Two common types of diabetes drugs both show significant reductions in major heart events for patients with a history of heart attacks.
SGLT2 inhibitors reduce body fat without significant impacts on skeletal muscle mass in type 2 diabetes
SGLT2 Inhibitors Reduce Fat Mass in Type 2 Diabetes Patients
This network meta-analysis of 5,399 patients evaluated the effects of SGLT2 inhibitors on body composition. The study found that while SGLT2…
New analysis shows SGLT2 inhibitors consistently reduce body fat and weight in adults with type 2 diabetes without significantly reducing mu…
Gut microbiota-derived aromatic amino acid metabolites influence myocardial injury and risk of major adverse cardiac events
Gut Microbiota Metabolites Linked to Cardiovascular Disease Risk
This systematic review synthesizes the roles of gut microbiota-derived aromatic amino acid (AAA) metabolites in cardiovascular disease. The …
Specific compounds from gut bacteria, like Phenylacetylglutamine, are linked to heart damage and increased risks for cardiovascular disease.
Symptom-informed updates increase predicted probabilities of hEDS and POTS in comorbid patients
New data reveals links between hEDS, POTS, and MCAS conditions
This meta-analysis synthesizes aggregate prevalence data to determine comorbidity probabilities among patients with hEDS, POTS, and MCAS. Th…
New research highlights how symptoms can help predict overlapping conditions like hEDS, POTS, and Mast Cell Activation Syndrome.
FDA Approves Furoscix (furosemide) for Edema in Heart Failure and CKD
FDA approves new diuretic Furoscix for heart and kidney patients
The FDA approved Furoscix (furosemide) subcutaneous injection for edema in pediatric patients weighing 43 kg and above and in adults with ch…
The FDA approved Furoscix (furosemide) to treat fluid buildup in adults and children weighing 43 kg or more with chronic heart failure or ki…
FDA Approves Kaletra (lopinavir/ritonavir) for HIV-1 Infection in Adults and Children
FDA approves new HIV drug Kaletra for adults and children.
FDA approved Kaletra (lopinavir/ritonavir) for treatment of HIV-1 infection in adults and pediatric patients 14 days and older, in combinati…
The FDA approved Kaletra (lopinavir/ritonavir) to treat HIV-1 infection in adults and children aged 14 days and older. It is used with other…
FDA Approves Kaletra (lopinavir/ritonavir) for HIV-1 Infection in Patients 14 Days and Older
FDA approves Kaletra to treat HIV in adults and children 14 days and older.
The FDA approved Kaletra (lopinavir/ritonavir) for HIV-1 infection in adults and pediatric patients 14 days and older, in combination with o…
The FDA approved Kaletra (lopinavir/ritonavir) for HIV-1 infection in adults and children as young as 14 days. It is used with other HIV med…
FDA Approves Ziac (bisoprolol/hydrochlorothiazide) for Hypertension
FDA approves Ziac, a new combination pill for high blood pressure.
FDA approved Ziac (bisoprolol fumarate/hydrochlorothiazide) for the management of hypertension. The combination provides additive blood pres…
The FDA approved Ziac, a combination of two blood pressure medicines, for treating hypertension. It is for patients who need more than one d…
FDA Approves Avapro (irbesartan) for Hypertension and Diabetic Nephropathy
FDA approves Avapro to treat high blood pressure and kidney disease in diabetes.
FDA approved Avapro (irbesartan) for hypertension and for diabetic nephropathy in hypertensive type 2 diabetes patients with elevated creati…
The FDA approved Avapro (irbesartan) for high blood pressure and for kidney disease in people with type 2 diabetes. It helps lower blood pre…
FDA Approves Rezdiffra (resmetirom) for Noncirrhotic NASH with Moderate to Advanced Fibrosis
FDA approves new drug Rezdiffra for fatty liver disease with scarring.
The FDA approved Rezdiffra (resmetirom) for adults with noncirrhotic NASH and F2 to F3 fibrosis, to be used with diet and exercise. Approval…
The FDA approved Rezdiffra (resmetirom) for adults with a type of fatty liver disease called NASH that has moderate to advanced scarring. It…
FDA Approves Dyna-hex 2 (chlorhexidine gluconate) for Surgical Hand Scrub and Healthcare Personnel Handwash
FDA approves Dyna-hex 2 antiseptic for surgical hand scrubs and healthcare handwash.
The FDA approved Dyna-hex 2 (chlorhexidine gluconate) for use as a surgical hand scrub and healthcare personnel handwash. It significantly r…
The FDA approved Dyna-hex 2 (chlorhexidine gluconate) as a surgical hand scrub and healthcare handwash to reduce bacteria on hands and forea…
Non-invasive vagus nerve stimulation reduces monthly headache days in migraine patients
Trial Shows Vagus Nerve Stimulation Reduces Migraine Frequency
This meta-analysis of 917 patients with migraine found that non-invasive vagus nerve stimulation (nVNS) significantly reduced monthly headac…
Non-invasive vagus nerve stimulation may reduce the number of monthly headache days and the need for acute medication for people living with…
Overweight and obesity prevalence in individuals with Down syndrome reaches 22% across mixed-age cohorts
Overweight and Obesity Rates are High Among People with Down Syndrome
This meta-analysis of 26 studies involving 7,840 individuals identifies a high prevalence of overweight and obesity in people with Down synd…
New data shows that overweight and obesity rates are significantly higher in people with Down syndrome compared to the general population.
Higher AMH levels in PCOS patients correlate with higher oocyte yields and increased OHSS risk
AMH hormone levels impact pregnancy success for women with PCOS
This systematic review and meta-analysis of women with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technology (ART) fo…
New data shows that specific hormone levels can signal different risks and success rates for women with PCOS undergoing fertility treatments…
AI-assisted clinicians achieve 1.000 sensitivity in melanoma diagnosis but autonomous AI lacks clear clinical advantage
Artificial Intelligence Shows Mixed Results in Detecting Melanoma
This meta-analysis of 17 diagnostic arms from 10 studies evaluates artificial intelligence for dermoscopic image analysis in melanoma detect…
New research shows that while AI can help identify skin cancer, it does not yet outperform traditional methods used by doctors.
Bibliometric analysis reveals expanding multidisciplinary research landscape for diabetes-related hearing loss
Diabetes and hearing loss: a growing link researchers are mapping
This systematic bibliometric review analyzed 1,622 publications to map the global research landscape of diabetes and hearing loss. The study…
A new analysis of 1,622 publications reveals a strong, growing link between diabetes and hearing loss, with research shifting toward age-rel…
Digital PCR provides a strong correlation with plaque assays for disinfectant efficacy testing
Digital PCR Shows Strong Correlation with Traditional Disinfectant Testing
This guideline-based validation study evaluates digital PCR (dPCR) as a complement to MS2 plaque assays for assessing virucidal activity. Th…
A new laboratory test shows that digital PCR can accurately track how well disinfectants kill viruses compared to traditional methods.
Protocol for comparing azithromycin and doxycycline with beta-lactams in community-acquired pneumonia
New trial to test azithromycin vs doxycycline for pneumonia
This is a protocol for a planned randomized clinical trial involving 1120 adult patients hospitalized with community-acquired pneumonia. No …
A large trial will compare two antibiotic combos for hospitalized pneumonia patients. Which works better?
Bacteriophages show promise as targeted anti-caries agents in systematic review
Bacteriophages Show Promise Against Cavities
This systematic review summarizes advances in phage-based interventions for dental caries, including phages targeting S. mutans and Actinomy…
Viruses that target bacteria could one day help prevent and treat cavities by killing cavity-causing germs.
Gut microbiota dysbiosis and metabolic pathway abnormalities are associated with pediatric Type 1 Diabetes
Gut bacteria linked to type 1 diabetes in children
This narrative review examines the role of gut microbiota in children with Type 1 Diabetes Mellitus. The authors synthesize evidence regardi…
Children with type 1 diabetes have less diverse gut bacteria, which may affect their immune system and metabolism.
Immunonutrition may improve management of radiation-induced oral mucositis in head and neck cancer patients
Immunonutrition may help manage mouth sores in head and neck cancer
This narrative review examines the role of immunonutrition for managing oral mucositis in patients with head and neck malignancies undergoin…
Patients with head and neck cancer often suffer from painful mouth sores. New evidence suggests immunonutrition could help manage these symp…
Calcium homeostasis dysregulation serves as an integrative regulatory node in allergic rhinitis inflammation
Calcium Imbalance May Drive Inflammation in Allergic Rhinitis
This systematic review explores the role of calcium signaling in allergic rhinitis pathogenesis, including mucosal barrier maintenance and i…
New research suggests that how your body manages calcium levels may play a key role in maintaining nasal barriers and driving allergic rhini…
Acidic microenvironments reprogram immune cells via pH sensors, driving tissue injury
Acidic environments in the body change how immune cells work
This systematic review synthesizes evidence that acidic microenvironments influence immune cell metabolism and effector functions through pr…
Your immune system uses special sensors to detect acid levels, which can trigger inflammation and tissue damage during infections or cancer.
Behavioral and metabolic factors characterize a distinct premature atherosclerosis phenotype in Chinese patients
Smoking and Metabolic Factors Linked to Heart Attacks in China
This systematic review of 317 observational studies maps risk factors for premature myocardial infarction (PMI) in China. The synthesis iden…
A large review of 317 studies identifies specific behavioral and metabolic risk factors for heart attacks among Chinese patients.
Orforglipron tablets and capsules are bioequivalent across six dose levels in adults with obesity
Trial Shows Orforglipron Tablets and Capsules Work the Same
This Phase 1 multicenter RCT evaluated orforglipron in 429 healthy adults with obesity or overweight. The study found that tablets and capsu…
A new clinical trial shows that orforglipron tablets are just as effective as capsules for people with obesity or who are overweight.
Incretin-based weight loss lower in type 2 diabetes trials, but confounded by demographics
Weight loss with incretin drugs may depend on patient profile
This meta-regression found that placebo-adjusted weight loss with incretin-based therapies was significantly lower in type 2 diabetes trials…
People with type 2 diabetes may lose less weight on incretin drugs, but it's likely due to other health factors, not diabetes itself.
ME/CFS linked to 7-fold higher odds of irritable bowel syndrome in meta-analysis
People with chronic fatigue syndrome often have irritable bowel issues
This meta-analysis reports that individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have significantly higher odds …
A new look at the data shows people with chronic fatigue syndrome are much more likely to also deal with irritable bowel symptoms.
AI models provide high accuracy for pulmonary inflammation and COVID-19 detection in diverse populations
Artificial Intelligence Shows Promise for Detecting Lung Inflammation
This mini-review synthesizes evidence on artificial intelligence applications for detecting pulmonary inflammation and managing perioperativ…
New research shows that artificial intelligence tools can accurately identify lung conditions like pneumonia and COVID-19 from medical imagi…