Medical Editor
Dr. Amelia Tan, PhD
Internal Medicine & Chronic Disease — Organ-system RCTs, biomarker endpoints, immune-mediated disease, biologics.
Dr. Amelia Tan is a freelance medical writer based in Singapore with over 10+ years of experience in clinical research, regulatory writing, and pharmaceutical communications, specializing in Internal Medicine & Chronic Disease. She holds a PhD in Biomedical Sciences from the National University of Singapore and a Master's degree in Clinical Research from Nanyang Technological University. She also holds certification in Good Clinical Practice (ICH-GCP) and regulatory writing standards.
Amelia's expertise spans organ-system clinical trials and biologic therapies, with a focus on cardiology, endocrinology, nephrology, pulmonology, gastroenterology, hematology, rheumatology, and immune-mediated diseases. She has extensive experience working with randomized controlled trials involving biomarker endpoints and chronic disease progression models.
Prior to transitioning into freelance writing, Amelia worked as a Clinical Research Scientist at a global pharmaceutical company, where she led multi-center trials across Southeast Asia. She is known for her ability to translate complex clinical datasets into clear, compliant, and publication-ready scientific content for regulatory authorities, clinicians, and research teams.
Articles in this group — last 14 days
Meningeal Immune System Offers New Target for Glioblastoma Immunotherapy
New approach targets the immune system to treat brain tumors
This systematic review explores how targeting the meningeal immune system, including dural lymphatics and rBAMs, could overcome current barr…
A new strategy focuses on the area where brain tumors meet the body's defenses to improve how immunotherapy works for glioblastoma.
A 6 dimension and 42 item system provides early risk assessment for high-risk diabetic feet
Experts Develop New Risk Assessment System for Diabetic Feet
This expert consultation and guideline describes the development of an early risk assessment system for high-risk diabetic feet. The consens…
A new assessment system identifies risk factors like nerve damage and circulation to help manage and prevent complications in patients with …
Postoperative AKI occurs in half of type A aortic dissection surgeries, meta-analysis finds
Factors Linked to Kidney Injury After Aortic Dissection Surgery
This meta-analysis of 44 studies (11,983 patients) found that 50.72% of patients undergoing surgery for Stanford type A aortic dissection de…
Over half of patients undergoing surgery for a specific type of aortic dissection develop acute kidney injury, with several risk factors ide…
Fixed AV delay after LBBAP for sinus node dysfunction: left atrial volume change at 12 months
New Strategy for Managing Heart Rhythm After LBBAP Procedure
This single-center randomized trial compared fixed optimized AV delay versus minimal ventricular pacing in 216 patients with sinus node dysf…
A new pacing strategy aims to prevent heart chamber changes and reduce irregular heartbeats in patients after a specific heart procedure.
Long-term personalized exercise therapy shows potential cost-effectiveness for patients with axial spondyloarthritis
Personalized exercise therapy shows promise for axial spondyloarthritis patients
Researchers evaluated the cost-utility of long-term, personalized exercise therapy compared to usual care in patients with axial spondyloart…
New research looks at whether personalized, long-term exercise programs are a cost-effective way to manage severe axial spondyloarthritis.
Precision nutrition offers dynamic optimization for managing patients with chronic liver disease through individualized metabolic profiles
Precision nutrition offers a new way to manage liver disease
This narrative review explores the role of precision nutrition in managing chronic liver disease. The authors argue that tailoring nutrition…
Tailoring nutrition to an individual's unique metabolism could change how doctors manage chronic liver disease and improve patient care.
Acute cellular senescence facilitates tissue repair while chronic accumulation drives intestinal fibrosis in Crohn's disease
Chronic cell aging may drive scarring in Crohn's disease
This systematic review examines the role of cellular senescence in intestinal fibrosis within Crohn's disease. The authors conclude that acu…
New research reveals how the timing of cellular aging determines whether your body heals properly or develops harmful scar tissue.
Nemolizumab Q4W improves IGA success maintenance by 11.8% over withdrawal in atopic dermatitis
Trial shows nemolizumab maintains skin results for atopic dermatitis
This Phase 3 randomized controlled trial evaluated nemolizumab in 507 adolescents and adults with moderate-to-severe atopic dermatitis who w…
A new trial found that nemolizumab helps maintain clear skin and reduce itching for adults and teens with moderate to severe atopic dermatit…
Pharmacist-led telepharmacy may improve medication adherence and reduce blood pressure in patients with NCDs
Pharmacist Led Telepharmacy May Improve Medication Adherence For Chronic Illness
This systematic review analyzed 21 trials involving 5440 participants to evaluate pharmacist-led telepharmacy for managing non-communicable …
Remote pharmacist services through phone or video may help patients with high blood pressure and diabetes stick to their daily medication pl…
Resveratrol supplementation significantly reduces LDL-C but lacks consistent impact on glycemic indices in type 2 diabetes
Resveratrol fails to improve blood sugar in type 2 diabetes
This umbrella review and meta-analysis of 10 meta-analyses evaluated resveratrol for managing type 2 diabetes. While a significant reduction…
Resveratrol supplements did not lower blood sugar or improve cholesterol in type 2 diabetes, except for a small drop in LDL cholesterol.
IVUS-guided PCI did not significantly reduce target-vessel failure compared to angiography-guided PCI
Trial shows IVUS guidance does not reduce risk for heart patients
This randomized controlled trial of 2020 patients undergoing complex PCI found that IVUS-guided PCI with stent-optimization criteria resulte…
New data suggests that using special ultrasound imaging during complex heart procedures may not lower the risk of major complications.
FDA Approves Linezolid Injection for Gram-Positive Infections Including Pneumonia and Skin Infections
FDA approves new antibiotic injection for serious bacterial infections
The FDA approved linezolid injection for nosocomial pneumonia, community-acquired pneumonia, complicated skin infections, and vancomycin-res…
The FDA approved linezolid injection for treating serious infections like pneumonia and skin infections caused by certain bacteria, includin…
FDA Approves Argatroban in Sodium Chloride for Thrombosis in HIT and PCI
FDA approves new blood thinner for patients with rare clotting disorder.
The FDA approved argatroban in sodium chloride injection for prophylaxis or treatment of thrombosis in adult patients with heparin-induced t…
The FDA approved Argatroban in Sodium Chloride injection to prevent or treat blood clots in adults with heparin-induced thrombocytopenia (HI…
FDA Approves Terlivaz (terlipressin) for Hepatorenal Syndrome with Rapid Kidney Function Decline
FDA approves new drug Terlivaz for kidney failure in liver disease patients.
The FDA approved Terlivaz (terlipressin) to improve kidney function in adults with hepatorenal syndrome with rapid reduction in kidney funct…
The FDA approved Terlivaz (terlipressin) to improve kidney function in adults with hepatorenal syndrome, a serious kidney complication of ci…
FDA Approves Exdensur for Add-On Maintenance Treatment of Severe Eosinophilic Asthma
FDA approves new long-acting shot Exdensur for severe asthma.
FDA approved Exdensur (IL-5 antagonist) for add-on maintenance treatment of severe eosinophilic asthma in patients aged 12 years and older. …
The FDA approved Exdensur as an add-on treatment for severe asthma in people 12 and older. It is given as a shot every six months. This new …
Pancreatic cancer involves multilayered mechanisms from environment to immune escape
Review reveals complex causes of pancreatic cancer
This narrative review synthesizes the multilayered mechanisms of pancreatic cancer, including environmental exposure, genetic susceptibility…
Pancreatic cancer arises from a mix of genetics, lifestyle, and inflammation, review finds.
LGI and LGL diets reduce body weight, lipid profiles, and inflammatory markers in humans
Low Glycemic Index Diets May Improve Weight and Cholesterol Levels
This meta-analysis of 1,265 participants analyzed the effects of low glycemic index (LGI) and low glycemic load (LGL) diets on metabolic hea…
A review of 1,265 people suggests that low glycemic index diets may help lower body weight, improve cholesterol, and reduce certain inflamma…
Curcumin as a theranostics agent: intrinsic fluorescence and protein affinity offer dual diagnostic and therapeutic potential
Curcumin shows potential as a tool for cancer and brain disease
This narrative review positions curcumin as a model theranostics agent for oncology and neurodegenerative diseases, highlighting its intrins…
Curcumin may help doctors see and treat complex diseases like cancer, but it faces hurdles like poor solubility in the body.
Intraoperative anesthesia handovers are associated with increased risk of mortality and morbidity in surgical patients
Anesthesia handovers during surgery are linked to higher patient risks
This systematic review and meta-analysis of 14 studies found that intraoperative anesthesia handovers are significantly associated with high…
Research shows that passing anesthesia care between staff during surgery is linked to higher rates of complications and longer stays in inte…
EmiratesMEDs competency framework establishes 9 thematic roles and 14 EPAs for UAE medical education
New UAE framework sets 85 competencies for medical graduates
This guideline outlines the EmiratesMEDs competency framework designed to harmonize undergraduate medical education in the United Arab Emira…
A national competency framework for UAE medical graduates defines 85 skills and 14 clinical tasks to standardize education.
Esketamine significantly reduces postoperative anxiety (SMD -1.23) and depressive symptoms (SMD -0.92) in adult patients
Esketamine reduces anxiety and depression after surgery
This meta-analysis of 1,312 adults undergoing general anesthesia found that esketamine significantly reduced both anxiety and depression pos…
New data shows esketamine can significantly lower feelings of anxiety and depression in adults following surgery.
Machine learning and postoperative indicators improve AUC for predicting anastomotic leak in gastric cancer surgery
Machine Learning Models May Better Predict Gastric Cancer Complications
This systematic review and meta-analysis of 18 studies involving 15,783 patients evaluated risk prediction models for anastomotic leak. The …
New analysis shows machine learning models may offer better accuracy in predicting surgical complications for patients with gastric cancer.
Structured physical activity improves FEV1% predicted by 5.79 and PAQLQ scores in patients with asthma
Structured Physical Activity Shows Benefits for People with Asthma
This meta-analysis of trials involving structured physical activity for at least 6 weeks found significant improvements in FEV1% predicted (…
Structured physical activity programs of at least 6 weeks may improve lung function and quality of life for people living with asthma.
Structured exercise improves 6-minute walk distance by 38.62 m in idiopathic pulmonary fibrosis
Structured exercise improves endurance for people with lung scarring
This systematic review and meta-analysis of 503 patients found that structured exercise, particularly mind-body integrated training, signifi…
Specific types of structured exercise can improve walking distance and breathing for people living with idiopathic pulmonary fibrosis.
CD8+ T cells and associated signaling pathways influence osteoclast formation and osteoblast differentiation in osteoporosis
Immune Cells and Signaling Pathways Influence Bone Health in Osteoporosis
This narrative review synthesizes the role of CD8+ T cells and related cytokines like IFN-gamma, CCL5, and IL-33 in bone metabolism. The aut…
New research highlights how specific immune cells and signaling pathways may play a dual role in protecting or promoting bone loss in osteop…
E3 ubiquitin ligases modulate SARS-CoV-2 replication and immune evasion through targeted protein degradation mechanisms
SARS-CoV-2 uses host enzymes to hide from the immune system
This mini-review explores the role of E3 ubiquitin ligases in the context of SARS-CoV-2 infection. The authors synthesize how these enzymes …
New research shows how the virus hijacks specific proteins in our cells to replicate and dodge our body's natural defenses.
Multi-marker models show higher diagnostic performance than single analytes for identifying recurrent implantation failure
Multi-marker models show promise for diagnosing recurrent implantation failure
This systematic review of 18 studies evaluates fluid-based biomarkers, including blood and uterine fluid, for diagnosing recurrent implantat…
Combining multiple biomarkers may offer a more accurate way to diagnose why some pregnancies fail to implant.
Ultra-processed food consumption is associated with metabolic syndrome, cardiovascular risk, and allergic diseases in children
Ultra-processed foods linked to childhood weight and heart risks
This narrative review synthesizes evidence regarding the impact of ultra-processed food (UPF) on pediatric health. High UPF intake is linked…
High intake of ultra-processed foods is linked to weight gain, metabolic issues, and higher rates of asthma and skin conditions in children.
Patients with post-COVID syndrome face significant thromboembolic risk requiring proactive monitoring and tailored anticoagulant treatments
Anticoagulant Drugs May Help Manage Thromboembolic Risks After COVID-19
This meta-analysis examines the prevalence of thromboembolic events in individuals with post-COVID syndrome. The analysis identifies a signi…
People with post-COVID syndrome may face a higher risk of blood clots, highlighting the need for proactive monitoring and tailored treatment…
Beta-alanine supplementation improves time to exhaustion in women with a pooled effect of SMD 0.49
Beta-alanine may help women exercise longer before getting tired
This systematic review and meta-analysis of 11 randomized controlled trials evaluated beta-alanine supplementation in women. The analysis fo…
New data suggests beta-alanine could help women push through fatigue during workouts, though the evidence is still early and limited.
High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes
High rates of diabetes complications found in adult Ugandans
This meta-analysis examined the prevalence of various diabetic complications, including neuropathy and retinopathy, in a large cohort of adu…
More than half of Ugandan adults with diabetes suffer from nerve damage, highlighting a critical need for earlier screening and better care.
Synthetic food production technologies offer a promising resource for resilient global food systems
Synthetic Food Technologies Offer Potential Path to Global Food Security
This review evaluates technological innovations in synthetic food production, including cell culture and microbial fermentation, to address …
New technologies like cell culture and microbial fermentation could help feed a growing global population, though high costs and regulations…
SGLT2 inhibitors associated with lower all-cause mortality in heart transplant recipients with type 2 diabetes
SGLT2 inhibitors associated with lower mortality in heart transplant patients
This meta-analysis examined the impact of SGLT2 inhibitor use on outcomes for heart transplant recipients with type 2 diabetes. The authors …
New analysis suggests SGLT2 inhibitors may lower death rates for heart transplant recipients with type 2 diabetes without increasing UTI ris…
Adolescent physical activity is associated with improved mental and physical health in early adulthood
Adolescent Physical Activity Linked to Better Health in Early Adulthood
This systematic review of 44 articles analyzed the impact of adolescent physical activity on health markers in early adulthood. The authors …
Staying active as a teenager may lead to better physical and mental health outcomes for young adults later in life.
Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
Cystatin C shows promise for early detection of kidney injury
This meta-analysis of 17 studies evaluates the diagnostic performance of Cystatin C for detecting acute kidney injury in patients with sepsi…
A new look at 17 studies suggests that Cystatin C could help doctors identify kidney damage in sepsis patients much earlier than current met…
Tirzepatide at maximum tolerated dose achieved 21.9% bodyweight reduction over 112 weeks
Trial shows tirzepatide helps maintain weight loss over two years
This Phase 3b randomized controlled trial evaluated tirzepatide in 378 adults with obesity over a 112-week period. Patients receiving the ma…
A long-term study shows that tirzepatide can help people with obesity maintain significant weight loss for up to 112 weeks.
Intrawound vancomycin powder reduces postoperative infection risk (OR 0.59) in high-risk fracture fixation cases
Vancomycin Powder May Reduce Infections After High Risk Fractures
This meta-analysis of 3185 patients found that intrawound vancomycin powder significantly reduced postoperative infection rates (OR 0.59; 95…
A review of data suggests that using vancomycin powder in wounds may lower infection rates for patients with serious bone fractures.
Rare overlap of myasthenia gravis and Kennedy's disease identified in case report
Rare Overlap Syndrome Linked to Myasthenia Gravis and Kennedy's Disease
This case report and literature review describes a patient with acetylcholine receptor antibody-positive myasthenia gravis overlapping with …
A rare overlap between Myasthenia Gravis and Kennedy's disease was identified in a patient, helping doctors better recognize this complex co…
Mechanism-based strategies including CAR-T and bispecific engagers offer options for rituximab-resistant primary membranous nephropathy
New Strategies Target Treatment Resistance in Membranous Nephropathy
This systematic review examines the multifactorial mechanisms of rituximab resistance in patients with primary membranous nephropathy. It id…
Researchers identify new ways to treat primary membranous nephropathy when standard rituximab treatments do not work.
Multitarget designs and microenvironment remodeling may overcome resistance to CAR T-cell therapy in B-cell malignancies
New Strategies Identified to Overcome CAR T-cell Therapy Resistance
This systematic review synthesizes current knowledge regarding resistance mechanisms and overcoming strategies for CAR T-cell therapy in rel…
Researchers identified specific ways to overcome resistance in CAR T-cell therapy for patients with certain types of blood cancers.
IVUS-guided PCI shows no significant difference over angiography-guided PCI for primary outcomes
Trial shows ultrasound imaging adds no benefit for heart surgery
This randomized controlled trial of 806 patients with unprotected left main coronary artery disease found that IVUS-guided PCI did not signi…
A large trial found that using ultrasound guidance during certain heart procedures did not improve safety or outcomes compared to standard m…
Argatroban switch stabilized clinical status in a patient with mechanical aortic valve and LVAD after HIT
Blood thinner switch stabilizes LVAD patient with rare clotting disorder
This case report describes the management of heparin-induced thrombocytopenia (HIT) in a patient with a mechanical aortic valve and left ven…
A patient with a mechanical heart valve and LVAD developed dangerous clots after heparin. Switching to argatroban stabilized their condition…
Multi-target therapies may address combined hypertension and dyslipidemia pathophysiology
Multi-Target Therapies May Address Combined Hypertension and High Cholesterol
This systematic review synthesizes evidence on synergistic mechanisms of hypertension and dyslipidemia, highlighting the RAAS/PPAR axis, AMP…
Combining treatments like statins and RAAS inhibitors may offer a more precise way to manage both high blood pressure and cholesterol levels…
FDA Approves Hympavzi (marstacimab) for Routine Prophylaxis in Hemophilia A and B Without Inhibitors
FDA approves Hympavzi to prevent bleeding in hemophilia A and B.
The FDA approved Hympavzi (marstacimab) for routine prophylaxis to prevent or reduce bleeding episodes in patients 12 years and older with h…
The FDA approved Hympavzi (marstacimab) to prevent or reduce bleeding episodes in people 12 and older with hemophilia A or B without inhibit…
FDA Approves Provocholine (methacholine chloride) for Bronchial Airway Hyperreactivity Diagnosis
FDA approves new test to help diagnose asthma in certain patients
The FDA approved Provocholine (methacholine chloride) for diagnosing bronchial airway hyperreactivity in adults and children aged 5 years an…
The FDA approved Provocholine, a drug used in a breathing test to diagnose airway hyperreactivity in people aged 5 and older who may have as…
Transcriptomic analysis identifies 337 high-confidence genes associated with Type 2 Diabetes in human pancreatic islets
Meta-analysis reveals 337 genes linked to type 2 diabetes in islets
This meta-analysis of transcriptomic data from human pancreatic islets identified 337 high-confidence T2D-associated genes. The study also d…
A meta-analysis of human pancreatic islets identified 337 high-confidence genes tied to type 2 diabetes, and a 10-gene panel perfectly disti…
Acupuncture modulates the microbiota-gut-brain axis to remodel microbial structure in patients with irritable bowel syndrome
Acupuncture May Help Manage Irritable Bowel Syndrome Symptoms
This systematic review examines how acupuncture influences the microbiota-gut-brain axis in patients with irritable bowel syndrome. The auth…
New research suggests acupuncture may help manage irritable bowel syndrome by improving gut bacteria and balancing the gut-brain connection.
Exercise interventions may improve adiposity and physical function in middle-aged or older adults with sarcopenic obesity
Exercise helps middle-aged and older adults with sarcopenic obesity
This umbrella review of systematic reviews synthesized evidence on exercise-based interventions for middle-aged and older adults with sarcop…
New research shows that exercise programs can improve body composition and physical function for older adults struggling with both muscle lo…
Dapirolizumab pegol increases BICLA response rate by 14.6% over placebo in moderate-to-severe SLE
Trial shows dapirolizumab pegol improves symptoms for lupus patients
This Phase 3 randomized controlled trial of 321 patients with moderate-to-severe, active SLE found that dapirolizumab pegol added to standar…
A new clinical trial found that dapirolizumab pegol significantly improved disease activity for adults with moderate to severe systemic lupu…
Sepsis Mortality Prediction Models Show Moderate Performance
Prediction models show moderate success in forecasting sepsis deaths
A meta-analysis of 84 studies finds that externally validated models for sepsis mortality achieve a pooled AUC of 0.794, but most studies ha…
New data from millions of records helps identify which factors most accurately predict if a patient with sepsis will survive.
Large language models provide automated feedback to improve diagnostic accuracy and report quality in radiology training
AI feedback helps radiology trainees learn faster, review finds
This systematic review of 7 studies examines the use of large language models (LLMs) for providing automated feedback in medical imaging edu…
A review of 7 studies finds AI feedback improves radiology trainees' report quality and accuracy, but experts still needed.
Reduced Shannon index indicates lower alpha-diversity in the gut microbiota of patients with primary biliary cholangitis
Gut Microbiota Differences Linked to Primary Biliary Cholangitis
This meta-analysis of 1,057 participants found that patients with primary biliary cholangitis have significantly lower Shannon index values …
A large review of patient data shows that people with primary biliary cholangitis have significantly lower gut bacterial diversity than heal…
Risk-adapted HLA delisting and imlifidase enable deceased-donor kidney transplantation for highly sensitized candidates
New guide helps transplant kidneys for hardest-to-match patients
This expert consensus provides a practical guideline for managing highly sensitized adult patients on the waitlist for deceased-donor kidney…
A new expert guide shows how to safely transplant kidneys into highly sensitized patients who have few options left.
Regenerative endodontic procedures may lead to unusual root morphology in immature teeth
Regenerative procedures can lead to unusual tooth root growth
This case report with literature review describes 2 immature teeth with pulp necrosis secondary to dens evaginatus treated with regenerative…
A new look at dental treatments shows that while some procedures save teeth, they can sometimes cause unexpected changes in how roots grow.
Gastrodia elata polysaccharides may improve cardiovascular health via gut microbiota mediated metabolic pathways
Gastrodia elata Polysaccharides May Support Heart Health via Gut Bacteria
This narrative review synthesizes evidence on how Gastrodia elata polysaccharides (GEPs) influence cardiovascular health through gut microbi…
New research suggests that certain compounds from the Gastrodia elata plant may improve heart health by interacting with gut bacteria to red…
Plant essential oils demonstrate significant inhibitory effects against key subgingival plaque microbial complexes in periodontitis
Plant essential oils show promise against gum disease bacteria
This systematic review synthesizes the antibacterial activity of plant essential oils, including carvacrol and thymol, against subgingival p…
Certain plant oils may fight the specific bacteria that cause periodontitis while also helping to block harmful biofilm from forming in the …
Fungal biotransformation platform may generate new anti-infective molecules to combat antimicrobial resistance
Fungal Biotransformation May Help Combat Antimicrobial Resistance
This narrative review discusses fungal biotransformation as a discovery platform for generating structurally refined metabolites with anti-i…
New research explores how fungal systems can transform chemicals into new molecules to help fight stubborn bacterial and fungal infections.
Pre-transplant coronary artery disease increases all-cause mortality and post-transplant cardiovascular events in kidney recipients
Pre-existing heart disease increases risks for kidney transplant patients
This meta-analysis of 112,416 kidney transplant recipients found that pre-existing coronary artery disease (CAD) is associated with signific…
Patients with pre-existing coronary artery disease face significantly higher risks of death and graft failure after receiving a kidney trans…
OTUD7B acts as a context-dependent regulator in various cancers and inflammatory conditions
Protein OTUD7B plays complex roles in cancer and heart health
This systematic review examines the molecular roles of OTUD7B across multiple malignancies and inflammatory models. The findings indicate th…
A protein called OTUD7B acts as a double-edged sword, helping some conditions while fueling the growth of others.
System-level strategies and task-shifted care improve equity in global allergic disease management
Systemic Changes Could Improve Asthma Care in Underserved Communities
This guideline provides a narrative review of the global burden of allergic diseases, specifically focusing on underserved populations. It s…
New strategies like community health workers and digital tools could help bridge the gap in asthma care for underserved populations worldwid…