If you or someone you know suffers from uncontrolled moderate to severe eosinophilic asthma, there's a new treatment being tested called KT-621. This Phase 2b study is designed to see how well KT-621 works and how safe it is for patients. Eosinophilic asthma is a type of asthma that can be particularly difficult to manage, and finding effective treatments is crucial for improving quality of life. The study will measure how KT-621 affects lung function, specifically looking at a measurement called FEV1, which indicates how much air you can forcefully exhale in one second. With 264 participants expected to enroll, this research could provide valuable insights into a new option for those who struggle to control their asthma symptoms. If successful, KT-621 might offer hope for better management of this challenging condition.
Phase 2b Study Evaluates KT-621 for Eosinophilic AsthmaCan KT-621 help people with severe asthma breathe easier?
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Key Takeaway
Evaluate KT-621's impact on FEV1 in eosinophilic asthma patients.
This Phase 2b study, sponsored by Kymera Therapeutics, Inc., is currently recruiting participants to evaluate the safety and efficacy of KT-621, an investigational oral drug, in adults with uncontrolled moderate to severe eosinophilic asthma. The study aims to enroll an estimated 264 participants and will measure the primary outcome of change from baseline in pre-bronchodilator FEV1. The trial will also assess the safety, tolerability, and pharmacokinetics of KT-621. The study began on January 28, 2026, with a primary completion date projected for December 2027. As this is an ongoing study, results regarding the efficacy and safety of KT-621 are not yet available.
What this means for you:
KT-621 is being tested as a potential new treatment for severe eosinophilic asthma. More on Asthma
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View Original Abstract ↓
Status: RECRUITING | Phase: PHASE2
Condition(s): Eosinophilic Asthma
Intervention(s): KT-621 (DRUG), Placebo (OTHER)
This Phase 2b study is designed to evaluate the safety and efficacy of KT-621 in participants with uncontrolled moderate to severe eosinophilic asthma.
The main goals of this study are to investigate how effective KT-621 is at treating uncontrolled moderate to severe eosinophilic asthma, the safety and tolerability of KT-621, and how KT-621 behaves in the body.
Primary Outcome(s): Change from baseline in pre-bronchodilator FEV1
Enrollment: 264 (ESTIMATED)
Lead Sponsor: Kymera Therapeutics, Inc.
Start: 2026-01-28 | Primary Completion: 2027-12
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