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Are there reports of birth defects from Zika Virus Infection in the U.S.?

high confidence  ·  Last reviewed July 8, 2026

There are documented reports of birth defects linked to Zika virus infections in the United States. These cases often involve infants born to mothers who had a confirmed or possible infection during pregnancy.

What the research says

A U.S. registry specifically tracks pregnancies and infants with suspected or confirmed Zika infections. This registry has recorded various individual birth defects associated with the virus 3.

Research indicates that Zika virus is a significant concern for pregnant women because it can cause severe consequences for the fetus. These complications include microcephaly, which is a condition where a baby's head is significantly smaller than expected 6. Other reported conditions linked to congenital Zika syndrome include brain calcifications, small head size (microcephaly), enlarged ventricles (ventriculomegaly), and low birth weight 7. Additionally, some children with possible prenatal exposure to the virus have been diagnosed with autism spectrum disorder 2.

What to ask your doctor

  • What are the known risks of Zika virus for pregnant individuals?
  • What specific birth defects are associated with congenital Zika syndrome?
  • How is Zika virus monitored in my local area?
  • What symptoms should I watch for if I am exposed to mosquito-borne illnesses?

This question is drawn from common patient questions about OB/GYN & Women's Health and answered using cited medical research. We do not provide individualized advice.