Can the new monthly injection Perseris be used to treat adult schizophrenia?
Perseris is a long-acting injectable form of risperidone, an atypical antipsychotic. It is given as a monthly shot under the skin. The U.S. Food and Drug Administration (FDA) has approved Perseris specifically for treating schizophrenia in adults 1. This means it is a treatment option for adults who have trouble remembering to take daily pills or who prefer a monthly injection.
What the research says
The FDA approval of Perseris is based on clinical studies showing it is safe and effective for schizophrenia in adults 1. Perseris is also known as TV-46000 in research. A phase 3 trial called RISE found that TV-46000 given once monthly significantly delayed relapse compared to placebo in adults with schizophrenia 9. A network meta-analysis of several studies confirmed that once-monthly TV-46000 reduces relapse risk at 6 months, with effectiveness similar to other long-acting injectable antipsychotics like aripiprazole and paliperidone 10. The same analysis found no major differences in side effects leading to discontinuation among these treatments 10. Other sources in this set discuss general risks in schizophrenia, such as heart rate changes 2 and metabolic effects 34, but they do not directly address Perseris.
What to ask your doctor
- Is Perseris a good option for me compared to my current medication?
- How does the monthly injection schedule fit into my routine?
- What side effects should I watch for with Perseris?
- Can I switch from my current antipsychotic directly to Perseris?
- How long does it take for Perseris to start working?
This question is drawn from common patient questions about Psychiatry and answered using cited medical research. We do not provide individualized advice.