GLP-1R exposure shows no causal link to most mental disorders except eating disorders
GLP-1 Receptor Agonists Show Mixed Links to Mental Health
This meta-analysis investigated the causal associations between GLP-1 receptor agonists and various mental health outcomes including anxiety…
New research explores how GLP-1 receptor agonists relate to conditions like anxiety and depression, finding no clear genetic link to most di…
Resting-state qEEG identifies distinct neurophysiological signatures in chronic schizophrenia compared to first-episode psychosis
Brain wave patterns help distinguish schizophrenia from early psychosis
This systematic review of 19 studies evaluates resting-state quantitative electroencephalography (qEEG) as a biomarker for schizophrenia and…
New research shows that specific brain wave changes can tell the difference between chronic schizophrenia and first-episode psychosis.
Virtual reality interventions significantly improve core symptoms and cognitive function in patients with schizophrenia
Virtual reality helps manage core symptoms of schizophrenia
This meta-analysis of 678 individuals with schizophrenia found that virtual reality (VR) interventions significantly improved overall psychi…
New data shows virtual reality can improve cognitive function and reduce key symptoms for people living with schizophrenia.
Public health interventions improve mental health in young people in LMICs: systematic review
Public health interventions improve mental health in young people in LMICs
A systematic review of 30 studies found that public health interventions, including digital health, improved mental health outcomes in young…
A review of 30 studies finds that public health interventions, including digital tools, can improve mental health in young people in low-inc…
Semaglutide Improves Metabolic Health in Schizophrenia Patients on Antipsychotics
Semaglutide improves blood sugar and weight in people with schizophrenia and prediabetes
A randomized, placebo-controlled trial in 154 overweight or obese individuals with schizophrenia and prediabetes receiving second-generation…
A new trial shows semaglutide helps lower blood sugar and reduce weight in people with schizophrenia who also have prediabetes or obesity.
Expressive writing plus digital cognitive therapy may aid schizophrenia recovery
Expressive writing and digital therapy may help schizophrenia recovery
This narrative review proposes integrating expressive writing with digital cognitive therapy for schizophrenia. The authors argue this combi…
A narrative review suggests combining expressive writing with digital cognitive therapy could improve functional outcomes for people with sc…
Brexpiprazole improves PANSS scores by 0.19 Cohen's d in early-episode schizophrenia versus placebo
Brexpiprazole helps early schizophrenia symptoms more than placebo in adults and teens
This post hoc analysis of Phase 3 trials evaluated brexpiprazole versus placebo in 476 adults and adolescents aged 13-35 years with early-ep…
A look at trial data shows brexpiprazole improved symptoms and daily functioning better than placebo for people with early schizophrenia.
Short allele of 5-HTTLPR linked to increased schizophrenia risk in Japanese cohort and meta-analysis
Short gene variant linked to schizophrenia risk in Japanese ancestry patients
This cohort study and meta-analysis in Japanese patients found a significant association between the 5-HTTLPR short allele and schizophrenia…
A specific gene variant appears more common in people with schizophrenia than in controls, suggesting a possible link to disease risk.
Pimavanserin adjunctive therapy shows small statistically significant reductions in PANSS scores below clinically meaningful thresholds for schizophrenia
Review finds pimavanserin offers little for schizophrenia negative symptoms
This systematic review and meta-analysis evaluated adjunctive pimavanserin in 1676 randomized participants with schizophrenia. The analysis …
A major review of 1,676 adults with schizophrenia found adding pimavanserin did not meaningfully improve negative symptoms, despite small st…
Systematic review and meta-analysis of gut microbiota in schizophrenia versus healthy controls
Gut Microbe Differences Linked to Schizophrenia
This systematic review and meta-analysis evaluated gut microbiota composition in individuals with schizophrenia compared to healthy controls…
A review of 48 studies finds gut bacteria patterns differ in people with schizophrenia, but key diversity measures show no clear change.
Systematic review on genetic factors in treatment-resistant schizophrenia
Genetic factors linked to treatment-resistant schizophrenia in European ancestry
This systematic review synthesizes genetic findings in treatment-resistant schizophrenia. It finds that common variants explain little liabi…
A review of 102 studies finds genetic markers are connected to treatment-resistant schizophrenia, but common variants explain little risk.
Systematic review of AI for schizophrenia prediction using medical imaging data
AI tools may help predict schizophrenia using brain scans from 185 studies
This systematic literature review examines 185 studies on artificial intelligence methodologies, including machine learning and deep learnin…
A review of 185 studies shows artificial intelligence can help identify patterns in brain scans to predict schizophrenia, offering new hope …
Questions about Schizophrenia
Will taking semaglutide help improve my physical quality of life if I have schizophrenia and prediabetes?
Semaglutide can improve physical quality of life in people with schizophrenia and prediabetes, likely by helping with weight loss and metabolic health.
Full answer →What does the research say about psychosis rates in people with bipolar disorder?
A large meta-analysis found that about 47% of people with bipolar disorder experience mood-incongruent psychosis, and psychotic symptoms are common, especially in bipolar I disorder.
Full answer →Is there a link between schizophrenia and higher heart rate based on recent studies?
Yes, recent studies show people with schizophrenia tend to have a higher resting heart rate, which may contribute to their increased risk of sudden cardiac death.
Full answer →Do GLP-1 drugs help reduce weight and sugar levels in severe mental illness?
Yes, GLP-1 drugs significantly reduce weight and HbA1c in people with severe mental illness, with low dropout rates, but benefits may fade after stopping.
Full answer →Will taking cariprazine help me lose weight if I previously used olanzapine?
Yes, switching from olanzapine to cariprazine may help you lose weight, based on a 12-week study showing modest weight reduction compared to aripiprazole.
Full answer →Does having schizophrenia increase the risk of heart problems like high heart rate?
Yes, schizophrenia is linked to a higher resting heart rate and increased risk of heart rhythm problems, according to a large meta-analysis.
Full answer →Can the new monthly injection Perseris be used to treat adult schizophrenia?
Yes, Perseris (risperidone) is FDA-approved for once-monthly subcutaneous injection to treat schizophrenia in adults.
Full answer →All Schizophrenia Articles
- GLP-1R exposure shows no causal link to most mental disorders except eating disorders
- Resting-state qEEG identifies distinct neurophysiological signatures in chronic schizophrenia compared to first-episode psychosis
- Virtual reality interventions significantly improve core symptoms and cognitive function in patients with schizophrenia
- Public health interventions improve mental health in young people in LMICs: systematic review
- Semaglutide Improves Metabolic Health in Schizophrenia Patients on Antipsychotics
- Expressive writing plus digital cognitive therapy may aid schizophrenia recovery
- Brexpiprazole improves PANSS scores by 0.19 Cohen's d in early-episode schizophrenia versus placebo
- Short allele of 5-HTTLPR linked to increased schizophrenia risk in Japanese cohort and meta-analysis
- Pimavanserin adjunctive therapy shows small statistically significant reductions in PANSS scores below clinically meaningful thresholds for schizophrenia
- Systematic review and meta-analysis of gut microbiota in schizophrenia versus healthy controls
- Systematic review on genetic factors in treatment-resistant schizophrenia
- Systematic review of AI for schizophrenia prediction using medical imaging data
- Exposure to T gondii linked to small psychiatric risks but causality remains uncertain in current reviews
- Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders
- Portuguese consensus conference identifies barriers and opportunities for managing cognitive impairment in schizophrenia
- FDA Approves Perseris (risperidone) for Treatment of Schizophrenia in Adults
- Schizophrenia linked to higher heart rate and QT dispersion in meta-analysis
- Methylphenidate ER Improves Functional Capacity in Stable Schizophrenia
- Semaglutide improves physical quality of life in schizophrenia with prediabetes
- Cariprazine showed modest weight reduction versus aripiprazole in schizophrenia patients previously treated with olanzapine
- GLP-1RAs reduce weight and HbA1c in severe mental illness with low discontinuation rates
- Meta-analysis finds decreased GDNF levels in bipolar disorder but high heterogeneity limits conclusions
- Meta-analysis reviews psychosis prevalence in bipolar disorder patients across 285 studies
- Systematic review shows high prevalence of covert cerebrovascular changes in schizophrenia patients compared to controls
- Diabetes and social support associations with cognitive impairment in elderly schizophrenia inpatients
- Longer untreated psychosis linked to less symptom improvement in first-episode schizophrenia
- Systematic review and meta-analysis finds 50% prevalence of antipsychotic polypharmacy in MENAT/EMRO countries
- FDA Approves Caplyta (lumateperone) for Schizophrenia in Adults
- Observational study identifies sensory perception differences in schizophrenia and first-episode psychosis
- Narrative review explores microbiome mechanisms as a promising adjunctive avenue for managing depression, anxiety, bipolar disorder, and schizophrenia
- Observational study identifies cortical organization and topological alterations in schizophrenia
- VR-CBTp and CBTp Outcomes for Schizophrenia Spectrum Disorders Paranoia in 254-Person RCT
- Parental severe mental illness associated with reduced offspring cognitive and academic performance in large meta-analysis
- ADHD and ASD polygenic risk scores correlate with antipsychotic responsiveness in schizophrenia postmortem brains
- Narrative review proposes connectomic-guided psychosurgery framework for treatment-refractory patients
- Systematic review links CNTN6 gene to neurodevelopmental and mental disorders
- Blood biomarker variance in UK Biobank influenced by technical, demographic, and behavioral factors
- Paracingulate sulcus prevalence reduced in patients with catatonia compared to controls
- Observational study links striatal dopamine changes to psychosis remission in schizophrenia patients
- Transcriptomic analysis of DLPFC identifies five-gene model for schizophrenia diagnosis in small cohort
- Observational study evaluates dynamic prediction model for clozapine initiation in Danish schizophrenia patients
- Elobixibat improved constipation in schizophrenia or depression patients during postmarketing surveillance in Japan
- Cognitive Remediation Therapy Re-analysis Shows Benefit Over Treatment As Usual on Global Assessment Scale
- Longitudinal MRI study links brain morphometry to treatment in schizophrenia spectrum disorders
- Multimodal MRI Protocol to Study Interoception in Schizophrenia
- Multi-omics data integration in Spanish psychiatric patients and controls
- Mendelian randomization suggests loneliness causally increases schizophrenia and major depressive disorder risk
- Cross-trait analyses reveal complex genetic overlaps between cortical morphology and psychiatric disorders
- Racial discrimination linked to negative symptoms in schizophrenia via defeatist beliefs
- Pathway-partitioned schizophrenia polygenic risk scores associate with age of psychosis onset in multi-ancestry cohorts
- Cohort study shows schizophrenia patients and siblings differ in gray matter volume compared to healthy controls
- Phase 2b trial finds basmisanil does not improve cognitive deficits in schizophrenia
- Meta-analysis finds gamma neuromodulation benefits in schizophrenia and major depressive disorder
- Immuno-kynurenine shifts track cognitive change in antipsychotic-naive first-episode schizophrenia
- Prochlorperazine Labeling: Indicated for Severe Nausea/Vomiting and Schizophrenia
- Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia
- C3 and C4 levels correlate with schizophrenia outcomes in a small cohort study
- MTHFR C677T polymorphism linked to elevated risk of schizophrenia and type 2 diabetes comorbidity in Han Chinese patients
- New NeuroMark SPECT template identified replicable perfusion networks in schizophrenia cohorts
- Plasma NfL levels elevated in bipolar and depressive disorders in UK Biobank cohort
- Mental health syndemics reduce ART adherence and impair viral suppression in people living with HIV
- Systematic review finds immune markers IL-1β and TNF-α associated with negative symptoms in first episode psychosis
- Normative latent cognitive structure metrics delineate cognitive heterogeneity across schizophrenia liability spectrum in healthy controls, siblings, and patients
- Corticolimbic Glutamate-Functional Connectivity Associations Found in Antipsychotic-Naive CHR-P Individuals
- Autonomic arousal moderates network switching-cognition link in healthy controls but not schizophrenia
- Technology-based social cognition training improved facial emotion recognition and empathy in adults with schizophrenia-spectrum disorders
- Plasma H2S levels rise with cognitive gains in schizophrenia patients on atypical antipsychotics
- Aerobic exercise and cognitive stimulation show no significant between-group cognitive benefits in schizophrenia trial
- Clozapine, olanzapine, or haloperidol reduced assaults in 99 individuals with schizophrenia and assaultive behaviors
- Right unilateral and bitemporal ECT show similar symptom improvement in resistant schizophrenia
- Cohort study in Portuguese families finds co-segregation of serious mental illnesses and rare CHD2 variant
- Aripiprazole linked to less insight improvement than dopamine antagonists in schizophrenia trial
- Danish cohort study identifies ten clinically distinct schizophrenia subgroups with genetic associations
- Gray matter volume deviations in schizophrenia linked to symptom severity and cognitive function
- Antipsychotic exposure shows time-dependent associations with vocational recovery in schizophrenia cohort
- Protocol published for trial testing tDCS plus cognitive training in schizophrenia
- Meta-analysis links auditory hallucinations in schizophrenia to specific brain activity patterns and neurotransmitter systems
- Case-control study links splenomegaly to elevated metabolic and inflammatory markers in chronic schizophrenia
- Active tDCS shows large effect on life engagement in schizophrenia outpatients versus sham
- Meta-analysis finds no evidence for atypical reliance on prior expectations in schizophrenia-spectrum psychosis
- Meta-analysis finds distinct hedonic deficits in schizophrenia and depression
- Psychological interventions show minimal symptom benefit, no substance use effect in schizophrenia with SUD
- Meta-analysis finds mGluR modulators show no significant efficacy for schizophrenia symptoms
- Case-control study finds no link between Toxoplasma gondii, IFN-γ polymorphism, and paranoid schizophrenia in males