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How do psychological interventions help with depression in early intervention for first-episode psychosis?

high confidence  ·  Last reviewed May 15, 2026

Depression is common in first-episode psychosis (FEP) and can affect recovery. Psychological interventions, such as cognitive behavioral therapy (CBT) and early intervention services (EIS), are designed to treat both psychotic and mood symptoms. Research shows these approaches can reduce depressive symptoms and improve overall outcomes in people with FEP.

What the research says

A 2023 umbrella review of meta-analyses found that early intervention services (EIS) for first-episode psychosis were superior to treatment as usual for depressive symptoms at the end of treatment 9. The same review reported that cognitive behavioral therapy (CBT) improved depressive symptoms in schizophrenia, which is relevant for FEP 9. A meta-analysis of 30 trials showed that psychological interventions at subclinical symptom levels reduced major depression incidence by 43% at post-treatment and 33% at 12-month follow-up 2. Additionally, early intervention for FEP reduced hospitalization by 26% 2. A 12-year follow-up study of extended early intervention in Hong Kong found that 50.5% of patients achieved personal recovery, which includes emotional well-being 7. Extended EIS also improved functioning and reduced overall symptom severity, including general psychopathology, which covers depressive symptoms 6.

What to ask your doctor

  • Would CBT or another psychological therapy be appropriate for my depressive symptoms?
  • How does early intervention for psychosis address both psychotic and mood symptoms?
  • What are the expected benefits of psychological interventions for depression in my situation?
  • Are there any risks or side effects of combining psychological therapy with medication?
  • How long should I continue psychological therapy to see improvement in depression?

This question is drawn from common patient questions about Psychiatry and answered using cited medical research. We do not provide individualized advice.