Resting-state qEEG identifies distinct neurophysiological signatures in chronic schizophrenia compared to first-episode psychosis
Brain wave patterns help distinguish schizophrenia from early psychosis
This systematic review of 19 studies evaluates resting-state quantitative electroencephalography (qEEG) as a biomarker for schizophrenia and…
New research shows that specific brain wave changes can tell the difference between chronic schizophrenia and first-episode psychosis.
Observational study identifies sensory perception differences in schizophrenia and first-episode psychosis
Simple tests reveal unique sensory signs for early psychosis types
This observational study investigated psychophysical differences in pictorial size perception and auditory discomfort among patients with sc…
New low-cost tests can spot unique sensory changes that help doctors tell schizophrenia apart from bipolar disorder in early psychosis cases…
Meta-analysis on psychological interventions and early psychosis care for depression and psychosis
Psychological interventions cut major depression risk by 43% after treatment
This meta-analysis synthesizes evidence on psychological interventions for subclinical depression and early intervention for first-episode p…
Early psychological help for subclinical symptoms lowers major depression risk by 43% after treatment and 33% a year later, a meta-analysis …
Criminal legal involvement correlates with baseline symptoms and substance use in US first-episode psychosis patients
Early psychosis care may lower the risk of arrest
This secondary analysis of a cluster randomized controlled trial examined criminal legal involvement (CLI) in 381 US patients with first-epi…
When psychosis is caught and treated sooner, people are less likely to end up tangled in the legal system during recovery.
Systematic review finds immune markers IL-1β and TNF-α associated with negative symptoms in first episode psychosis
Inflammation Linked to Low Energy in Early Psychosis
A systematic review of 7 case-control studies found individuals with first episode psychosis generally showed elevated peripheral blood immu…
High levels of inflammatory markers in the blood are linked to the low energy and lack of motivation seen in people with early psychosis.
Extended early intervention service improves functioning in first-episode psychosis versus standard care
Extending early intervention services may improve functioning for some young people with first-episode psychosis
A randomized controlled trial of 400 individuals with first-episode psychosis found that extending early intervention service (EIS) for one …
Extending early intervention care for young people with first-episode psychosis leads to higher employment rates and better social functioni…
Corticolimbic Glutamate-Functional Connectivity Associations Found in Antipsychotic-Naive CHR-P Individuals
Could early brain changes in psychosis risk be linked to specific chemical connections?
An observational study of antipsychotic-naive clinical high-risk for psychosis (CHR-P) participants (n=22), healthy controls (n=23), and fir…
People at high risk for psychosis show weaker brain chemical connections before symptoms appear, unlike those who have already developed the…
12-year follow-up of extended early intervention for first-episode psychosis in Hong Kong
Long-term study tracks recovery rates for people with first psychosis episode
A 12-year follow-up of an RCT in Hong Kong compared a 1-year extension of early intervention (3-year EI) to 1-year step-down care (2-year EI…
Twelve years after a first psychosis episode, only 25% of patients regained daily functioning, though extra early care helped control sympto…
Research across Psychosis
Related studies from across the Psychosis family.
High-potency cannabis products are consistently linked to increased risks of psychosis and anxiety symptoms
High Potency Cannabis Linked to Increased Risk of Psychosis
This narrative review examines the mental health consequences of contemporary high-potency cannabis use in Europe. The authors synthesize ev…
New research highlights a consistent link between high-potency cannabis products and increased risks of psychosis, anxiety, and panic sympto…
Exposure to T gondii linked to small psychiatric risks but causality remains uncertain in current reviews
Cat owners might face higher risks for certain mental health struggles
Current reviews suggest small-to-moderate associations between T. gondii exposure and conditions like schizophrenia, yet evidence for cat ow…
New research suggests a hidden parasite from cats might slightly increase the risk of mental health issues like schizophrenia and anxiety in…
Psychosis Prevalence in SLE Patients: Meta-Analysis of 31,495 Adults
Lupus psychosis risk is higher than doctors thought
A meta-analysis of 31,495 SLE patients found psychosis prevalence of 4.5% overall and 20.5% in NPSLE, highlighting the need for clinical vig…
Many people with lupus may face a higher risk of psychosis than previously believed, and a key antibody could help spot those most at risk.
Observational cohort links symptom severity subgroups to poorer functioning and brain volume in psychosis and depression risk
Severe Mental Symptoms Share Hidden Common Cause
This observational cohort study stratified 749 participants into transdiagnostic symptom severity subgroups.
This could explain why different mental illnesses feel so similar in early stages.
In children with first psychotic symptoms, 23.5% had substance- or medically-associated psychosis after extensive workup
Medical testing found substance or medical causes in 23.5% of youth with new psychosis
This retrospective cohort study evaluated 68 children and adolescents admitted for a first presentation of psychotic symptoms at a tertiary …
Medical testing found substance or medical causes in 23.5% of youth with new psychosis, proving a thorough workup is essential before diagno…
Large language models show potential for psychosis risk assessment from clinical interview transcripts
AI language models show promise for assessing early psychosis risk from interviews
An evaluation study of 373 participants with clinical high risk for psychosis transcripts found that large language models (LLMs) achieved 8…
Large AI models correctly identified early psychosis risk 80% of the time from interview transcripts, matching human expert scores while mos…
Aripiprazole linked to less insight improvement than dopamine antagonists in schizophrenia trial
Can reducing symptoms help people with schizophrenia gain insight into their illness?
A 6-week RCT of 144 schizophrenia spectrum disorder patients found symptom reduction was associated with improved clinical insight.
Reducing symptoms helps people with schizophrenia gain insight into their illness, but early improvement in hallucinations and delusions mat…
Planned trial compares injectable antipsychotics to usual care for psychosis with stimulant use
Hong Kong trial planned to test antipsychotic injections for substance use with psychosis
A trial record describes a planned phase 2/3 study of 165 individuals in Hong Kong with substance use disorders and psychosis.
Hong Kong researchers plan a trial to test long-acting antipsychotic injections for people with substance use disorders and psychosis.
Questions about First-Episode Psychosis
What glutamate connectivity associations are found in antipsychotic-naive first-episode psychosis individuals?
In antipsychotic-naive first-episode psychosis, higher anterior cingulate glutamate+glutamine (Glx) is linked to altered functional connectivity in salience, default mode, and executive control networks, with weaker or reversed associations compared to healthy controls.
Full answer →How do psychological interventions help with depression in early intervention for first-episode psychosis?
Psychological interventions help reduce depression in first-episode psychosis by addressing mood symptoms early, improving functioning, and lowering hospitalization risk.
Full answer →What immune markers are associated with negative symptoms in first episode psychosis?
IL-1β and TNF-α are the immune markers most consistently linked to negative symptoms in first-episode psychosis, though associations are modest.
Full answer →Are there sensory perception differences identified in first-episode psychosis patients compared to others?
Yes, first-episode psychosis patients show sensory perception differences, including altered visual size perception, auditory discomfort, and impaired olfactory identification.
Full answer →