Mode
Text Size
Log in / Sign up

What are the risks of getting an infection after lung surgery with pleural effusion?

high confidence  ·  Last reviewed May 26, 2026

Getting an infection after lung surgery is a serious concern, especially when fluid builds up around the lungs. Research shows that a patient's physical condition before the operation, known as frailty, plays a major role in infection risk. However, the presence of fluid around the lungs, called pleural effusion, is a separate issue that is not directly predicted by frailty scores.

What the research says

A study of 391 patients who had lung resection found that frailty is a strong, independent predictor of postoperative pulmonary infection. Patients classified as frail or pre-frail had significantly higher odds of developing an infection compared to those who were robust. This risk remained high even after adjusting for other factors like age and existing health conditions 3.

The same study looked at whether frailty predicted other complications like pneumothorax or pleural effusion. The results showed that frailty did not predict the development of pleural effusion after the surgery. This suggests that while frailty makes infection more likely, the fluid buildup around the lungs is caused by different factors 3.

Another study looked at elderly patients with heart failure and moderate pleural effusion. It compared standard diuretic therapy against pleural drainage procedures. The study found that using diuretics led to shorter times for the fluid to resolve on its own and shorter hospital stays. There were no significant differences in readmission rates between the two groups, suggesting that managing fluid with medication can be as effective as drainage in some cases 2.

A third study protocol describes a trial for patients in the ICU with respiratory failure and pleural effusion. This trial plans to use ultrasound-guided drainage to improve oxygen levels. The protocol specifically excludes patients who already have an infection in the pleural space, known as empyema, or those with bleeding disorders. This highlights that infection is a specific risk that must be managed carefully before and during drainage procedures 1.

What to ask your doctor

  • What is the best treatment for my pleural effusion, medication or drainage?

This question is drawn from common patient questions about Pulmonology & Critical Care and answered using cited medical research. We do not provide individualized advice.