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Home › Conditions › pleural effusion

Pleural effusion

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for pleural effusion

14 trials tracked for pleural effusion: 3 in phase 3 or 4.

14Trials tracked
3Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 1 Phase 3 2 Phase 2 5 Other / NA 6
  1. Phase 4 Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical Pleurodesis Completed
  2. Phase 3 Use of Vasopressin Following the Fontan Operation Completed
  3. Phase 3 Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer Completed
  4. Phase 2 FDG-Labeled PET Scan in Planning Chemotherapy in Treating Patients With Stage IIIB or IV Non-Small Cell Lung Cancer Completed
  5. Phase 2 AZD0530 in Treating Patients With Extensive Stage Small Cell Lung Cancer Completed
  6. Phase 2 Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Completed
Show 8 more trials
  1. Phase 2 Imatinib Mesylate and Paclitaxel in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer Completed
  2. Phase 2 Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer Completed
  3. N/A Catheter Placement for Hepatic Hydrothorax Completed
  4. N/A Active Clearance of Chest Tubes After Cardiac Surgery: A Prospective Randomized Controlled Study Completed
  5. N/A Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program Completed
  6. N/A Safety and Effectiveness of a New Pleural Catheter for Symptomatic, Recurrent, MPEs Versus Approved Pleural Catheter Completed
  7. N/A Evaluation of a Pocket-Sized Ultrasound Device As an Aid to the Physical Examination Completed
  8. N/A Vacuum vs Manual Drainage During Unilateral Thoracentesis Completed

Showing the 14 most-cited and recently-updated of 14 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Feasibility trial protocol for ultrasonography-guided therapeutic pleural drainage in ICU patients with pleural effusion and respiratory failure
Emergency Medicine RCT
Feasibility trial protocol for ultrasonography-guided therapeutic pleural drainage in ICU patients with pleural effusion and respiratory failure A new trial protocol checks if ICU drainage helps adults with fluid buildup and breathing trouble
This feasibility trial protocol evaluates ultrasonography-guided therapeutic pleural drainage with small-bore catheter in adults acutely adm…
This feasibility trial protocol checks if draining fluid from the lungs helps adults in the ICU who have breathing trouble and fluid buildup…
May 1, 2026
Standard diuretic therapy within GDMT yielded comparable outcomes to pleural drainage in elderly acute heart failure with moderate pleural effusion
Cardiology Cohort
Standard diuretic therapy within GDMT yielded comparable outcomes to pleural drainage in elderly acute heart failure with moderate pleural effusion Heart Failure Fluid Buildup: One Treatment May Be Enough
This retrospective observational cohort study of 514 elderly acute heart failure patients with moderate pleural effusion in China found that…
For many older heart failure patients, standard medication alone may be just as effective as a procedure to drain fluid from the lungs, pote…
Frontiers Apr 20, 2026
5-factor frailty index predicts postoperative pulmonary infection but not pneumothorax or effusion after lung resection
Rheumatology Cohort
5-factor frailty index predicts postoperative pulmonary infection but not pneumothorax or effusion after lung resection A Simple 5-Question Score Predicts Your Biggest Risk After Lung Surgery
This retrospective cohort study evaluated 391 patients undergoing lung resection to assess the association between 5-factor modified frailty…
A fast health check you can do in a clinic is surprisingly good at spotting who needs extra protection from infections after major lung surg…
Frontiers Apr 13, 2026
Serum NT-proBNP levels demonstrate high diagnostic accuracy for congestive heart failure-related pleural effusions in a meta-analysis
Cardiology Meta-analysis
Serum NT-proBNP levels demonstrate high diagnostic accuracy for congestive heart failure-related pleural effusions in a meta-analysis Blood Test Beats Fluid Drain for Heart Failure Clues
This systematic review and meta-analysis evaluated the diagnostic utility of serum NT-proBNP levels for identifying congestive heart failure…
A simple blood test can diagnose heart failure with fluid buildup as accurately as invasive fluid drainage, sparing patients uncomfortable p…
Apr 12, 2026

Questions about pleural effusion

Can small-bore catheters be used for pleural drainage in ICU patients with effusion?

Small-bore catheters are used for pleural drainage in ICU patients, often guided by ultrasound, though success depends on fluid complexity and patient stability.

Full answer →
What are the risks of getting an infection after lung surgery with pleural effusion?

Frailty before surgery is a strong predictor of getting a lung infection after lung resection, but it does not predict the risk of developing a pleural effusion itself.

Full answer →