Phase 4 study evaluates nitroglycerin's effects on stroke volume in 21 AHF patients

A Phase 4 study, completed at Copenhagen University Hospital, Hvidovre, evaluated the effects of nitroglycerin on heart function and urinary output in patients with acute heart failure (AHF). The study aimed to understand how nitroglycerin, which relaxes blood vessels, affects patients with AHF, a condition characterized by the heart struggling to pump blood effectively, leading to fluid buildup and breathing difficulties. The investigators hypothesized that nitroglycerin could increase blood flow from the heart and promote urine production, potentially reducing congestion in AHF patients. The primary outcome measured was stroke volume. The study enrolled 21 patients with AHF. The study period ran from February 1, 2025, to November 30, 2025. The goal of the research was to identify which patients may benefit most from nitroglycerin therapy by studying heart function, blood volume, and fluid levels during treatment. The abstract does not report specific results, safety signals, or study limitations.