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ICE vs TEE for atrial fibrillation ablation: no significant safety differences, shorter fluoroscopyICE and TEE show similar safety for heart procedures

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Key Takeaway
Consider ICE as a reasonable alternative to TEE for AF ablation, noting low certainty for safety equivalence.

This meta-analysis compared intracardiac echocardiography (ICE) with transesophageal echocardiography (TEE) in 4760 adults undergoing atrial fibrillation catheter ablation (ICE n = 2616; TEE n = 2144). The analysis included cohort studies and one RCT, yielding low to very low certainty evidence.

For procedural safety, there were no significant differences between ICE and TEE for cardiac tamponade (OR 0.67, 95% CI 0.33-1.36), stroke/TIA/thromboembolism (OR 0.81, 95% CI 0.36-1.78), vascular complications (OR 1.22, 95% CI 0.70-2.13), or bleeding (OR 0.50, 95% CI 0.22-1.12). Total procedure duration also showed no difference (mean difference -7.11 min, 95% CI -18.82 to 4.61). However, fluoroscopy time was significantly shorter with ICE (mean difference -4.17 min, 95% CI -6.07 to -2.26).

The authors caution that the absence of significant differences likely reflects imprecision rather than demonstrated equivalence. The evidence is low to very low certainty, and results should be regarded as hypothesis-generating.

In practice, ICE may be a reasonable alternative to TEE in appropriately selected patients at centers with established ICE expertise. However, the limitations preclude strong recommendations for superiority or equivalence.

How this fits prior evidence

This meta-analysis extends prior coverage of catheter ablation in atrial fibrillation by comparing two imaging modalities used during the procedure. Prior findings showed that catheter ablation reduces serious adverse events and unplanned hospitalizations compared to antiarrhythmic drugs, and that fragmented QRS is associated with a 2.11 risk ratio for post-ablation atrial tachyarrhythmia. The current analysis adds that ICE and TEE have similar safety profiles, though with low certainty, and ICE shortens fluoroscopy time. It does not directly address the comparative effectiveness of ablation versus drugs or the prognostic value of fQRS.

When doctors perform a procedure to treat atrial fibrillation, they need clear images of the heart. They often choose between two types of ultrasound: Intracardiac Echocardiography (ICE) and Transesophageal Echocardiography (TEE). Because both methods are used to keep patients safe during these complex surgeries, it is important to know if one is safer or faster than the other.

A large review of data from over 4,700 patients found that both ICE and TEE performed similarly. Specifically, there were no significant differences between the two methods regarding serious risks like bleeding, vascular complications, or strokes. The total time spent on the procedure was also similar for both groups.

One small difference was noted: using ICE led to slightly less fluoroscopy time, which is the X-ray imaging used during surgery. However, it is important to note that the evidence for these findings is currently low to very low certainty. This means while they look similar now, more research is needed to be certain of their equivalence.

What this means for you:
Both ICE and TEE show similar safety results for heart procedures, though more research is needed.

Common questions

Is one imaging method safer than the other?

The study found no significant difference in safety between Intracardiac Echocardiography (ICE) and Transesophageal Echocardiography (TEE). Both methods showed similar results regarding risks like bleeding, vascular complications, and stroke. However, because the evidence is of low to very low certainty, these results are currently used to help form hypotheses rather than provide a definitive answer.

Does one method make the procedure faster?

The total duration of the procedure was similar for both ICE and TEE. However, patients who had the ICE method experienced slightly less fluoroscopy time (X-ray imaging) during their surgery. You should talk to your doctor about which technology is best suited for your specific case.

What are the risks involved in these procedures?

Potential risks during these heart procedures include cardiac tamponade, stroke or TIA (temporary blockage of blood flow), vascular complications, and bleeding. The study found that neither ICE nor TEE significantly changed the rates of these specific complications.

Study Details

Study typeMeta analysis
Sample sizen = 2,616
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
PURPOSE: Transesophageal echocardiography (TEE) is the standard periprocedural imaging modality for atrial fibrillation (AF) catheter ablation but carries the burden of esophageal instrumentation, frequent deep sedation, and logistical constraints. Intracardiac echocardiography (ICE) is a growing alternative, yet comparative evidence had not been systematically synthesized. This systematic review and meta-analysis compared ICE and TEE as periprocedural imaging strategies in adults undergoing AF catheter ablation, focusing on safety and procedural efficiency. METHODS: A search of PubMed, Embase, CENTRAL, and Web of Science identified six eligible studies (five cohort studies and one multicenter randomized controlled trial) enrolling 4760 participants (ICE n = 2616; TEE n = 2144). Peto odds ratios (OR) were used for dichotomous safety outcomes and mean differences (MD) with random-effects models for continuous outcomes; certainty of evidence was graded using GRADE. RESULTS: ICE was not associated with significant differences in periprocedural complications, including cardiac tamponade (Peto OR 0.67, 95% CI 0.33-1.36), stroke/TIA/thromboembolism (0.81, 0.36-1.78), vascular complications (1.22, 0.70-2.13), or bleeding (0.50, 0.22-1.12). Total procedure duration did not differ (MD -7.11 min, 95% CI -18.82 to 4.61). ICE was associated with shorter fluoroscopy time (MD -4.17 min, -6.07 to -2.26), though this was attenuated after excluding studies with combined left atrial appendage occlusion. Certainty of evidence was low to very low; the absence of significant differences reflects imprecision rather than demonstrated equivalence and should be regarded as hypothesis-generating. CONCLUSION: Within these limitations, ICE may be a reasonable alternative to TEE in appropriately selected patients at centers with established ICE expertise. PROSPERO: CRD420251239269.
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