One-year post-CABG diastolic function worsens despite preserved ejection fraction in ischemic heart disease patients.

Background: Ischemic heart disease impairs left ventricular (LV) diastolic function, but little is known about changes in the mechanical properties of LV relaxation following coronary artery bypass grafting (CABG). Objectives: This study aimed to explore if and how the mechanics of LV filling change following CABG. Methods: Patients underwent transthoracic echocardiography before and one year after elective CABG. Mitral inflow E-waves were analysed using the parameterized diastolic filling (PDF) method, allowing for quantification of mechanical properties of diastolic function. Results: Among patients (n=96, 10% female, median [interquartile range] age 68 [62-74] years), LV ejection fraction (LVEF) at baseline was 59 [53-63] %. At follow-up, there was an increase in the PDF-derived measures of myocardial stiffness, damping, peak driving and resistive forces, together with increase in left atrial (LA) volume index, and a decrease in LA conduit and contractile strains and tricuspid annular plane systolic excursion (p<0.001 for all). There was no change in heart rate, LV size, LVEF, E/e ratio, or LV filling efficiency. Furthermore, there were no differences in the mechanics of LV filling in patients when grouped according to baseline LVEF, or the number of revascularized coronary arteries. Conclusions: One year after CABG, there was consistent deterioration in the mechanics of diastolic filling assessed using mechanistic evaluation. Revascularization with CABG worsens diastolic function one year after CABG. However, causes and significance of these changes remain to be further investigated. The PREFERS study is registered at clinicaltrials.gov with ID-number NCT03671122. Graphical abstractDeterioration in LV diastolic properties one year after CABG. Overview of background, study design, methods and main results. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=141 SRC="FIGDIR/small/24318125v6_ufig1.gif" ALT="Figure 1"> View larger version (45K): [email protected]@197e6dcorg.highwire.dtl.DTLVardef@1b57655org.highwire.dtl.DTLVardef@6bd4a9_HPS_FORMAT_FIGEXP M_FIG C_FIG