High neutrophil-to-albumin ratio associated with increased 30-day mortality in acute aortic dissection patients

This retrospective cohort study included 415 patients with acute aortic dissection diagnosed at Yuebei People's Hospital. The primary exposure was the neutrophil-to-albumin ratio (NPAR), compared against other inflammatory markers including NLR, SII, and PLR, as well as the lowest NPAR tertile. The primary outcome was 30-day mortality, with follow-up lasting 30 days.

Analysis revealed that higher NPAR values were independently associated with increased 30-day mortality. The adjusted odds ratio was 1.48 (95% CI: 1.05–2.09; P = 0.027). When comparing mortality risk between tertiles, patients in the highest NPAR tertile demonstrated significantly greater mortality risk than those in the lowest tertile. Specific absolute numbers for mortality events were not reported in the provided data.

Safety and tolerability data, including adverse events, discontinuations, and serious adverse events, were not reported. The study design is observational, meaning the findings reflect association rather than causation. Funding sources and conflicts of interest were not reported. The authors did not overstate the certainty of the results, and practice relevance was not explicitly defined in the input data.