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Systematic literature review examines machine learning applications in congenital heart disease across 432 references

Systematic literature review examines machine learning applications in congenital heart disease acro…
Photo by CDC / Unsplash
Key Takeaway
Note that this review of 432 references lacks reported outcomes or safety data for machine learning in congenital heart disease.

This systematic literature review evaluates the application of machine learning within the context of congenital heart disease. The authors compiled and analyzed 432 references sourced from leading journals to provide a broad overview of the topic. The review serves as a narrative synthesis rather than a primary trial or quantitative meta-analysis.

The scope of the review covers the general utilization of machine learning in this specific medical domain. The authors did not report specific primary or secondary outcomes, nor did they detail adverse events or tolerability profiles for the technologies discussed. Consequently, the review focuses on the existence and scope of the literature rather than quantitative efficacy or safety metrics.

Limitations acknowledged by the authors include the lack of reported outcomes and the absence of a defined comparator group within the synthesized references. The review does not establish causality or provide definitive practice recommendations due to the observational nature of the included literature. Funding sources and potential conflicts of interest were not reported.

Given the absence of specific outcome data and safety information, the clinical relevance remains uncertain. Clinicians should interpret these findings as a broad survey of available literature rather than evidence supporting specific interventions. Further research is needed to clarify the practical utility and safety of these technologies.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
Congenital heart disease is among the most common fetal abnormalities and birth defects. Despite identifying numerous risk factors influencing its onset, a comprehensive understanding of its genesis and management across diverse populations remains limited. Recent advancements in machine learning have demonstrated the potential for leveraging patient data to enable early congenital heart disease detection. Over the past seven years, researchers have proposed various data-driven and algorithmic solutions to address this challenge. This paper presents a systematic review of congenital heart disease recognition using machine learning, conducting a meta-analysis of 432 references from leading journals published between 2018 and 2025. A detailed investigation of 74 scholarly works highlights key factors, including databases, algorithms, applications, and solutions. Additionally, the survey outlines reported datasets used by machine learning experts for congenital heart disease recognition. Using a systematic literature review methodology, this study identifies critical challenges and opportunities in applying machine learning to congenital heart disease.
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