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Residual angina occurs in 42.2% of patients after anatomic complete revascularization for chronic coronary diseaseResidual angina affects over 40% of patients after complete heart artery treatment

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Key Takeaway
Note that residual angina affects over 40% of patients after complete revascularization without increasing mortality.

This randomized controlled trial enrolled 2588 participants randomized to invasive management for chronic coronary disease. The population consisted of symptomatic patients with baseline angina, defined by a Seattle Angina Questionnaire Angina Frequency score less than 100. Participants had no prior coronary artery bypass graft surgery and underwent anatomic complete revascularization within 90 days of randomization. The study setting location was not reported in the provided data.

The primary outcome assessed the frequency of residual angina after revascularization. This was defined as a Seattle Angina Questionnaire Angina Frequency score less than 100 within six months of randomization. Among the 436 participants who achieved anatomic complete revascularization, 184 individuals experienced residual angina. This represents an incidence of 42.2% in this specific subgroup.

Several secondary outcomes measured health status and functional limitations at six months. The Seattle Angina Questionnaire Quality of Life score was 70 plus or minus 20 in the residual angina group versus 83 plus or minus 20 in the group without residual angina. This difference had a p-value less than 0.001. The Seattle Angina Questionnaire Physical Limitation score was 84 plus or minus 20 versus 95 plus or minus 11, with a p-value less than 0.001.

Additional assessments included the Rose Dyspnea Scale score, which was 1 plus or minus 1.3 versus 0.4 plus or minus 0.8, with a p-value less than 0.001. Medication use for angina showed a statistically significant difference with a p-value of 0.006, indicating greater use in the residual angina group. Procedural data showed percutaneous coronary intervention was used in 88% of cases versus 80% for coronary artery bypass graft surgery, with a p-value of 0.03.

Long-term mortality outcomes were evaluated at five years. Five-year all-cause death and five-year cardiovascular death did not differ significantly between groups. Specific absolute numbers or p-values for these mortality endpoints were not reported. Safety data regarding adverse events, serious adverse events, discontinuations, and tolerability were not reported in the available information.

A key limitation noted was that baseline characteristics were similar between those with and without residual angina. The study design does not explicitly distinguish between association and causation beyond the trial structure. Furthermore, the data does not explicitly distinguish between surrogate and clinical outcomes beyond the trial design. Funding sources and conflicts of interest were not reported.

Clinically, residual angina is common following anatomic complete revascularization for chronic coronary disease. The incidence exceeds 40% and is associated with reduced quality of life and greater antianginal medication use. However, this condition does not appear to increase the risk of death. Questions remain regarding the specific etiologies of residual angina and strategies to mitigate persistent symptoms in this population.

Many people with chronic coronary disease expect that clearing their blocked arteries will stop their chest pain. This research shows that chest pain, known as angina, remains common even after doctors believe they have fully treated the heart arteries. Over 40% of patients still experience symptoms within six months of the procedure. This finding matters because it affects how patients feel about their recovery and how they manage their daily activities. Understanding that this pain can persist helps set realistic expectations for healing. The study looked at a large group of patients to see how often this happens and what it means for their health.

The researchers studied 2,588 patients with chronic coronary disease. These individuals had symptoms like chest pain before starting treatment. They all received invasive management to open their arteries. The goal was anatomic complete revascularization, meaning doctors aimed to clear all blockages. The team tracked these patients for six months to see how their symptoms changed. They also followed up with them for five years to check for serious events like death. The study focused on patients who had not had previous bypass surgery.

The main finding was that 184 out of 436 patients with complete revascularization still had angina within six months. This group represented 42.2% of those analyzed. Patients with ongoing pain reported lower quality of life scores compared to those without pain. They also reported greater physical limitations, meaning their daily tasks were harder to perform. Breathing difficulties were more common in the group with residual pain. Additionally, these patients used more antianginal medications to manage their symptoms. The study also noted that patients with ongoing pain were more likely to have undergone percutaneous coronary intervention rather than bypass surgery.

Safety was not a primary focus of the reported results. The study did not report specific adverse events or discontinuations related to the procedures. However, the presence of residual pain clearly impacts quality of life and requires ongoing medication use. The five-year follow-up showed that death rates from any cause or from heart problems did not differ significantly between patients with and without residual pain. This suggests that while the pain is bothersome, it does not necessarily increase the risk of dying in the short or medium term.

People should not overreact to this single study. The baseline characteristics were similar between groups, which strengthens the comparison. However, this is one trial and results can vary in other settings. The study shows an association between incomplete symptom relief and certain procedures, but it does not prove that one caused the other in a simple way. Patients should discuss their specific symptoms with their doctors. Realistically, this means that having chest pain after treatment does not mean the procedure failed. It is a known outcome that requires management. Patients should talk to their care team about strategies to handle persistent symptoms and improve their quality of life.

What this means for you:
Residual angina affects 42% of patients after treatment and lowers quality of life but does not increase death risk.

Study Details

Study typeRct
Sample sizen = 2,588
EvidenceLevel 2
Follow-up6.0 mo
PublishedMay 2026
View Original Abstract ↓
BACKGROUND: The frequency of residual angina and its impact on health status and death following anatomic complete revascularization in symptomatic patients with chronic coronary disease are unknown. METHODS: Data were analyzed from ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) trial participants randomized to invasive management with baseline angina (Seattle Angina Questionnaire Angina Frequency score <100), no prior coronary artery bypass graft surgery, and anatomic complete revascularization within 90 days of randomization. The primary outcome was frequency of residual angina after revascularization, defined as a Seattle Angina Questionnaire Angina Frequency score <100 within 6 months of randomization. Secondary outcomes included 6-month health status and medication use and 5-year all-cause and cardiovascular death. RESULTS: Among 2588 participants randomized to invasive management, 1442 (56%) had baseline angina and no prior coronary artery bypass graft surgery; 1034 underwent revascularization within 90 days, and 436 achieved anatomic complete revascularization. Of these, 184 (42.2%) had residual angina within 6 months. Baseline characteristics were similar between those with and without residual angina. Percutaneous coronary intervention was more common than coronary artery bypass graft surgery in those with residual angina (88% versus 80%, =0.03). At 6 months, residual angina participants reported lower quality of life (Seattle Angina Questionnaire Quality of Life: 70±20 versus 83±20, <0.001), greater physical limitation (Seattle Angina Questionnaire Physical Limitation: 84±20 versus 95±11, <0.001), more dyspnea (Rose Dyspnea Scale score: 1±1.3 versus 0.4±0.8, <0.001), and more antianginal medication use (=0.006). Five-year all-cause and cardiovascular death did not differ significantly between groups. CONCLUSIONS: Residual angina is common (>40%) following anatomic complete revascularization for chronic coronary disease and is associated with reduced quality of life and greater antianginal medication use but no increase in death. REGISTRATION: Unique Identifier: NCT01471522.
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